A5060574996- Esophageal and GI Pathology
- Immune Response and Inflammation
- Cardiac, Anesthesia and Surgical Outcomes
- Immune cells in cancer
- Pleural and Pulmonary Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Esophageal Cancer Research and Treatment
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Dysphagia Assessment and Management
- Pancreatic and Hepatic Oncology Research
- Atrial Fibrillation Management and Outcomes
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Metastasis and carcinoma case studies
- Pericarditis and Cardiac Tamponade
- Gastrointestinal Tumor Research and Treatment
- Gastroesophageal reflux and treatments
- Intestinal Malrotation and Obstruction Disorders
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Lung Cancer Research Studies
- Ethics in medical practice
University of Manitoba
2023-2024
McGill University Health Centre
2014-2021
McGill University
2013-2020
Ottawa Hospital
2018-2020
University of Ottawa
2018-2020
Montreal General Hospital
2015-2016
The majority of patients with cancer undergo at least one surgical procedure as part their treatment. Severe postsurgical infection is associated adverse oncologic outcomes; however, the mechanisms underlying this phenomenon are unclear. Emerging evidence suggests that neutrophils, which function first line defense during infections, facilitate progression. Neutrophil extracellular traps (NETs) neutrophil-derived DNA webs released in response to inflammatory cues trap and kill invading...
Despite advances in cancer treatment, metastasis remains today the main cause of death. Local control through complete surgical resection primary tumor continues to be a key principle treatment. However, interventions themselves lead adverse oncologic outcomes and are associated with significantly increased rates metastasis. Neutrophils release neutrophil extracellular traps (NETs) response infections were shown able capture circulating cells, doing so, support development metastatic...
Surgery is required for the curative treatment of lung cancer but associated with high rates postoperative pneumonias predominantly caused by gram negative bacteria. Recent evidence suggests that these severe infectious complications may decrease long term survival after hospital discharge via recurrence, mechanism unclear. Lung cells have recently been demonstrated to express Toll‐like receptors (TLR) mediate pathogen recognition. We hypothesized incubation non‐small cell (NSCLC)...
Abstract While emerging data suggest nucleotide oligomerization domain receptor 1 (NOD1), a cytoplasmic pattern recognition receptor, may play an important and complementary role in the immune response to bacterial infection, its cancer metastasis is entirely unknown. Hence, we sought determine effects of NOD1 on metastasis. expression paired human primary colon cancer, murine cells were determined using immunohistochemistry immunoblotting (WB). Clinical significance was assessed TCGA...
Surgical resection of early stage nonsmall cell lung cancer (NSCLC) is necessary for cure. However, rates postoperative bacterial pneumonias remain high and may confer an increased risk metastasis. Toll-like receptors (TLRs) mediate the inflammatory cascade by recognizing microbial products at surface numerous types in lung; however, little known about how host TLRs influence NSCLC TLR2 recognizes gram-positive wall components activating innate immunity. We demonstrate that lower respiratory...
IntroductionSurgery is essential for cure of early-stage non-small cell lung cancer (NSCLC). Rates postoperative bacterial pneumonias, however, remain high, and clinical data suggests that post-operative infectious complications confer an increased risk metastasis. Toll-like receptors (TLRs) mediate the inflammatory response to infection by recognizing evolutionarily conserved structures at surface numerous pulmonary types; yet, little known about how host TLR activation influences NSCLC...
Intussusception refers to the telescoping of a segment bowel into lumen an adjacent segment. While pediatric intussusception is common and generally idiopathic, adult exceedingly rare usually attributable pathologic lead point. 37-year-old man who presented with abdominal pain, was preoperatively diagnosed colo-colonic intussusception. Intraoperatively, point found be congenital bands, there no evidence underlying malignancy. He underwent laparoscopic-assisted extended right hemicolectomy...
<h3>Background:</h3> There is controversy about the safety and outcomes of completion total gastrectomy (CTG) for gastric adenocarcinoma. We compared a cohort patients who underwent CTG remnant cancer (GRC) after partial benign disease with primary (PTG) sporadic cancer. <h3>Methods:</h3> retrospectively reviewed single-institution, prospectively maintained clinical database had undergone from 2005 to 2016 demographic, surgical, tumour pathology data, as well postoperative, pathologic...
Abstract Background The incidence of adverse events (AEs) and length stay (LOS) varies significantly following paraesophageal hernia surgery. We performed a Canadian multicenter positive deviance (PD) seminar to review individual center national level data establish holistic perioperative practice recommendations. Methods A virtual PD was in October 2021. Recent best evidence focusing on AEs LOS presented. Subsequently, anonymized center‐level AE collected between 01/2017 01/2021 from...
Zenker diverticulum is a mucosal herniation at the pharyngoesophageal junction. Although open surgical myotomy conventional treatment, robust evidence on third-space flexible endoscopic lacking. We assessed safety, effectiveness, and patient-reported outcomes of per-oral (Z-POEM) in largest reported single-center experience with this technique.
Abstract Background Lung cancer is a leading cause of death partially due to high recurrence rates after surgical resection. Clinical data suggest that post-operative infections may increase the risk recurrence. Our previous work indicated increased adhesion circulating tumors in context infection responsible for this phenotype. However, metastasis multi-step process, and it likely other events following tumor also play role. Methods In vivo intrasplenic injection murine lung cells into wild...
Abstract Introduction: Post-operative infectious complications in cancer patients confer an increased risk of death from distant metastasis, and activated neutrophils appear to be central cellular players this phenomenon. We have previously demonstrated that Neutrophil extracellular traps (NETs), composed neutrophil-derived DNA webs, are intricately implicated process by directly binding capturing circulating tumor cells. However, the mechanisms mediating interaction remain completely...
Abstract Lung cancer is the leading cause of death. Surgery remains essential for cure. However, postoperative infections particularly pneumonia remain high and confer an increased risk metastasis. Emerging evidence implicates Toll-like receptor (TLR) signalling in tumor progression after systemic infection. We hypothesize bacterial increases lung cell adhesion metastasis that these effects are mediated part by TLR signalling. C57BL6 mice were intranasally inoculated with 10^5 CFU/mL S....