A5012285927- Dementia and Cognitive Impairment Research
- Substance Abuse Treatment and Outcomes
- Smoking Behavior and Cessation
- Nutritional Studies and Diet
- Alzheimer's disease research and treatments
- Cardiovascular Health and Risk Factors
- Cannabis and Cannabinoid Research
- GDF15 and Related Biomarkers
- Gut microbiota and health
- Functional Brain Connectivity Studies
- Intergenerational Family Dynamics and Caregiving
- Advanced Neuroimaging Techniques and Applications
- Obesity, Physical Activity, Diet
- Religion, Spirituality, and Psychology
- Neurological Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Nutrition and Health in Aging
- Diabetes Management and Research
- Sharing Economy and Platforms
- Ginkgo biloba and Cashew Applications
- Parental Involvement in Education
- Psychological and Temporal Perspectives Research
- Genetics, Aging, and Longevity in Model Organisms
- Metabolomics and Mass Spectrometry Studies
National Institute on Aging
2022-2025
Indiana University Bloomington
2016-2024
Chung Shan Medical University
2023
Institute on Aging
2023
National Institutes of Health
2023
National Cheng Kung University
2017
Objective: Existing literature on young adults' e-cigarette and polysubstance use focused college students. This study examined the differences between noncollege groups prevalence patterns of other substance using data from a national survey. Participants: Adults aged 18–24 2013–2014 Population Assessment Tobacco Health Study (n = 6,608). Methods: Independent sample t-tests Chi-square tests were conducted to examine group differences. Results: Noncollege adults had higher cigarette,...
Abstract Background Animal and human studies suggest the gut microbiome is linked to diabetes but additional data are needed on associations of specific characteristics. The aim this study was examine composition insulin resistance [Homeostatic Model Assessment Insulin Resistance (HOMA-IR)], duration diabetes, 4 stages [normoglycemia, pre-diabetes, with (+) without (−) medication for diabetes]. Methods Data from a sub-sample (n = 605) Black White participants 30-year follow-up exam...
Abstract The plasma proteome can mediate associations between periodontal disease (Pd) and brain white matter integrity (WMI). We screened 5089 UK Biobank participants aged 40–70 years for poor oral health problems (POHP). examined the association POHP WMI (fractional anisotropy (FA), mean diffusivity (MD), Intracellular Volume Fraction (ICVF), Isotropic (ISOVF) Orientation Diffusion (OD)), decomposing total effect through of 1463 proteins into pure mediation, interaction, neither, while...
The plasma proteome's mediating or moderating roles in the association between poor cardiovascular health (CVH) and brain white matter (WM) microstructural integrity are largely unknown. Data from 3953 UK Biobank participants were used (40-70 years, 2006-2010), with a neuroimaging visit 2014 2021. Poor CVH was determined using Life's Essential 8 (LE8) reversing standardized z-scores (LE8z _rev). proteome examined as potential mediator moderator of LE8z _rev's effects on quantitative...
Background: Biological aging reflects the age and physiological function of cells tissues. In this study, we examined potential long-term influence cardiovascular-related factors from midlife (mean ~ 50) on epigenetic clock measured in late life 81 years). Methodology: Data demographic cardiovascular risk were collected Reykjavik Study (RS), Iceland (n=1,553, 56.9% female). Blood-based DNA samples 30 years later as a part Age, Gene/Environment Susceptibility-Reykjavik (AGES), which is an...
Midlife elevated blood pressure (BP) is an important risk factor associated with brain structure and function. Little known about trajectories of BP that modulate this risk.To identify trajectory patterns from young adulthood to midlife are in midlife.This cohort study used data US adults Coronary Artery Risk Development Young Adults (CARDIA), a prospective longitudinal Black White men women (baseline age 18 30 years) examined up 8 times over years (1985-1986 2015-2016). There were 885...
Abstract Persistent infections, whether viral, bacterial or parasitic, including Helicobacter pylori infection, have been implicated in non-communicable diseases, dementia and other neurodegenerative diseases. In this cross-sectional study, data on 635 cognitively normal participants from the UK Biobank study (2006–21, age range: 40–70 years) were used to examine H. seropositivity (e.g. presence of antibodies), serointensities five antigens a measure total persistent infection burden...
Abstract Background Early identification of dementia is crucial for prompt intervention high-risk individuals in the general population. External validation studies on prognostic models have highlighted need updated models. The use machine learning prediction its infancy and may improve predictive performance. current study aimed to explore difference performance algorithms compared traditional statistical techniques, such as logistic Cox regression, all-cause dementia. Our secondary aim was...
The goal of this study is to investigate the association between chronic non-cancer pain (CNCP) and mild cognitive impairment (MCI)/Alzheimer’s disease related dementias (ADRDs) development among adults aged ≥50 using administrative claims data from a national commercial health insurance company during 2007–2017. To reduce selection bias, propensity-score matching was applied select comparable CNCP non-CNCP patients. Time-dependent Cox proportional-hazards regressions were conducted estimate...
Background: Problematic alcohol drinking has been a public health concern in the United States. Studies showed that religiosity serves as protective factor, delaying onset of use, and reducing frequency drinking. Few studies, however, have examined these associations with large, nationally representative samples, even fewer assessed impact on behavior transitions/changes. Objectives: This study national adult sample to investigate between use stages including initiation, reinitiation,...
This study examined the levels and rates of changes in psychological well-being for middle-aged adults different statuses or marital transitions. The moderating effects leisure activities were also tested. Longitudinal data on 1,270 persons aged 50 to 65 years at baseline from Taiwan longitudinal aging analyzed. Adults who stably unmarried unpartnered reported worse mental health baseline, but their improved over time. trajectory depressive symptoms fluctuated markedly became widowed during...
Pathways explaining racial/ethnic and socio-economic status (SES) disparities in white matter integrity (WMI) reflecting brain health, remain underexplored, particularly the UK population. We examined SES diffusion tensor magnetic resonance imaging (dMRI) markers, namely global tract-specific mean fractional anisotropy (FA), tested total, direct indirect effects through lifestyle, health-related cognition factors using a structural equations modeling approach among 36,184 Biobank...
Mediation pathways explaining racial/ethnic and socioeconomic (SES) disparities in structural MRI markers of brain health remain underexplored. We examined SES sMRI tested total, direct, indirect effects through lifestyle, health-related, cognition factors using a equations modeling approach among 36,184 UK Biobank participants aged 40-70 years at baseline assessment (47% men). Race (non-White vs. White) lower SES-predicted poorer volumetric outcomes follow-up, with involving multiple...
<title>Abstract</title> <bold>Background</bold>: Chronological age alone does not sufficiently explain aging heterogeneity. Biological clocks and molecular biomarkers proposed to predict biological can be difficult implement in a clinical setting. Aim: In the framework of translational science, use routinely collected hematological markers develop clock estimate acceleration mice. <bold>Methods</bold>: Data from 2,562 mice both sexes three strains were drawn Study Longitudinal Aging Mice The...