To evaluate the independent and interactive effects of eye rubbing atopy on keratoconus (KC) in central China.A total 330 KC patients controls were recruited case-control study. Eye history recorded through face-to-face interviews. The association between rubbing, atopy, analyzed by logistic regression, odds ratios (OR), relative excess risk due to interaction (RERI), attributable proportion (AP), synergy (S) index, 95% confidence intervals (95% CI) calculated.A 228 (69.09%) had an history,...

Abstract The aim of this study was to evaluate the distribution new Corneal Visualisation Scheimpflug Technology (Corvis ST) parameters in normal, Post-laser situ keratomileusis (LASIK), Post-LASIK keratectasia (KE) and keratoconus (KC) eyes, explore diagnostic ability these distinguishing KE from LASIK eyes. Twenty-three normal 23 eyes KC were recruited study. following Corvis ST measured: Max Inverse Radius, deformation amplitude (DA) Ratio [2 mm], Pachy Slope, DA [1 Ambrosio’s relational...

To evaluate the distribution of pediatric keratoconus patients and disease severity based on different age gender groups in China.A total 446 eyes 266 from January 2019 to 2022 were included cross-sectional study. The clinical findings recorded Kruskal-Wallis test, chi-squared Cochran-Mantel-Haenszel (CMH) test used compare parameters between groups.The male/female ratio was 353/93 (3.8:1), median 16 years (range: 6-17 years). Male statistically younger than female (P = 0.041). decreased...

Abstract Background Although body mass index (BMI) and eye rubbing are linked to an increased risk of keratoconus (KC), the interactive effect BMI on KC is largely unknown. This study aimed evaluate independent effects further explore role environmental factors occurrence KC. Methods A total 621 individuals (291 patients 330 control individuals) were enrolled in this hospital‑based Central China after missing data excluded. was calculated as weight kilograms divided by square height meters....

Abstract Background The precision of anterior segment biometric measurements in eyes has become increasingly important refractive surgery. purpose this study is to assess the repeatability automatic provided by a new spectral-domain optical coherence tomograph (SD-OCT)/Placido topographer (MS-39, CSO) and its agreement with swept-source OCT (SS-OCT) biometer (CASIA SS-1000, Tomey) patients myopia. Methods right eye 235 subjects was scanned 3 times both devices. evaluated parameters included...

Purpose: Keratoconus (KC) is a progressive corneal disease that can lead to blindness if not properly managed. The purpose of this study was identify genetic associations with KC in China and investigate whether these variants are associated thickness curvature cases. Methods: A genome-wide association conducted on 853 patients 6248 controls. cases were genotyped the Illumina Infinium Human Asian Screening Array BeadChip, controls Global BeadChip. Genetic KC, as well correlations between...

Abstract China is a populous country but lacks epidemiological data on keratoconus (KC). The present study aimed to investigate the clinical data, demographic and visual function (VF) of KC patients in Central China. A total 524 eyes 307 (217 bilateral 90 unilateral) from Henan Eye Hospital were included current study. Demographic VF assessed with questionnaires administered by well-trained staff during face-to-face interviews. Visual acuity value was examined qualified optometrist, measured...

To describe the development of bacterial keratitis after small incision lenticule extraction in 5 patients and to explore its appropriate therapies.We retrospectively summarized clinical treatments five with postoperative infection extraction, who were referred our hospital from 2019 2021.Five male had undergone bilateral SMILE local due myopia aged 18 26 years. The onset during 1-3 days postoperatively four them severe (2 bilateral, 2 unilateral). In cases, 1 patient (1 eye) was infected...

Purpose: To investigate the differences in corneal biomechanical parameter stress-strain index (SSI) among different degrees of myopic eyes Chinese individuals and to analyze relevant factors SSI. Methods: This study analyzed right 240 participants (240 eyes) aged 18-34 years. The were divided into low-, moderate-, high-, ultra-high myopia groups according their spherical equivalent (SE), with 60 included each group. Spherical, cylinder, SE measured via automatically integrated optometry....

To preliminary explore the correlations among corneal biomechanical parameters, stiffness, and thickness in patients with ocular hypertension (OHT) before after treatment topical antiglaucoma medications. This was a retrospective study that included 35 eyes newly diagnosed OHT. Axial length (AL), apical thickness, minimum were measured using Pentacam. The lengths, velocities, times of first second applanations (A1L, A1V, A1T, A2L, A2V, A2T, respectively); highest concavity radius; peak...

Keratoconus (KC), characterized by progressive corneal protrusion and thinning, is a complex disease influenced the combination of genetic environmental factors. The purpose this study was to explore potential gene‒environment interaction between calpastatin (CAST) gene eye-rubbing in KC.

Background: Patients with unilateral post-LASIK keratectasia (KE) have clinical ectasia in one eye but not the fellow eye. As serious complications, these cases are rarely reported worth investigating. This study aimed to explore characteristics of KE and accuracy corneal tomographic biomechanical parameters detect distinguish eyes from control eyes. Methods: The analyzed 23 eyes, 48 normal age- sex-matched patients who had undergone LASIK. Kruskal-Wallis test further paired comparisons were...

Purpose Keratoconus (KC) is a corneal ectasia disease with complex genetic heterogeneity. The present study aimed to identify susceptibility genes in Chinese patients KC.Methods Exome sequencing (ES) was performed 28 KC search for of the disease. candidate variants were filtered out by multi-step bioinformatics analysis and validated Sanger sequencing. Another 100 individuals also recruited verify those sequencing.Results By filtering nonsynonymous located exon, selecting which presented two...

The present study investigated the prevalence of keratoconus (KC) among first-degree relatives KC patients in Central China.From July 2018 to March 2022, 661 384 were included study. Corneal tomography, uncorrected distance visual acuity, manifest refraction with corrected intraocular pressure, slit-lamp microscopy, and fundus examination performed. diagnosis was based on Belin/Ambrosio enhanced ectasia total deviation value (BAD-D value) Pentacam® system (Oculus GmbH). BAD-D <1.6 diagnosed...

Background Highly cited papers are expected to have high-quality data that significantly contribute the body of knowledge. The study aimed evaluate characters 100 most-cited articles on corneal cross-linking (CXL) through a bibliometric analysis. Materials and Methods Web Science database was searched identify published from 1950 2020. A analysis top 100-cited conducted in current study. citation differences between basic research, clinical reviews were compared by Kruskal–Wallis test....

ObjectiveTo obtain insight into the molecular process implicated in venous malformations (VMs) and identify potential targets for treatment of VMs, this study profiled gene expression pattern investigated alterations syndecan-1 (SDC1) tested hypothesis that aberrant SDC1 triggers abnormal angiogenesis VM development.MethodsMicroarray analysis was performed to differentially expressed genes (DEGs) on a transcriptome-wide level VMs conjunctive normal. Gene Ontology functional Kyoto...

Background: Keratoconus (KC) occurs at puberty but diagnosis is focused on adults. The early of pediatric KC can prevent its progression and improve the quality life patients. This study aimed to evaluate ability corneal tomographic biomechanical variables through machine learning analysis detect subclinical keratoconus (SKC) in a population. Methods: Fifty-two KC, 52 SKC, control eyes matched by age gender were recruited case-control study. parameters measured professionals. A linear...