A5085270299- Advanced Mathematical Modeling in Engineering
- Stability and Controllability of Differential Equations
- Retinal Diseases and Treatments
- Cholesterol and Lipid Metabolism
- Chronic Lymphocytic Leukemia Research
- GDF15 and Related Biomarkers
- Immune cells in cancer
- Contact Mechanics and Variational Inequalities
- Numerical methods for differential equations
- Numerical methods in inverse problems
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Atherosclerosis and Cardiovascular Diseases
- Glycosylation and Glycoproteins Research
- Sirtuins and Resveratrol in Medicine
- Apelin-related biomedical research
- Retinal Imaging and Analysis
- Immunodeficiency and Autoimmune Disorders
- Photoreceptor and optogenetics research
- Vibration and Dynamic Analysis
- Food composition and properties
- Acute Lymphoblastic Leukemia research
- Agriculture and Rural Development Research
- Advanced Mathematical Physics Problems
Cheikh Anta Diop University
2006-2022
École Polytechnique de Thiès
2021-2022
Washington University in St. Louis
1971-2021
Laboratoire de Mathématiques d'Orsay
2004-2021
Hôpital Aristide Le Dantec
2015-2019
Unité de Modélisation Mathématique et Informatique des Systèmes Complexes
2012
Inserm
2009-2010
Sorbonne Université
2010
Institut de la Vision
2009-2010
Université Polytechnique Hauts-de-France
2006
Zika virus (ZIKV) is an emerging flavivirus that causes congenital abnormalities and Guillain-Barré syndrome. ZIKV infection also results in severe eye disease characterized by optic neuritis, chorioretinal atrophy, blindness newborns conjunctivitis uveitis adults. We evaluated of the using recently developed mouse models pathogenesis. ZIKV-inoculated mice conjunctivitis, panuveitis, cornea, iris, nerve, ganglion bipolar cells retina. This phenotype was independent entry receptors Axl or...
Abstract Macrophage dysfunction plays a pivotal role during neovascular proliferation in diseases of ageing including cancers, atherosclerosis and blinding eye disease. In the eye, choroidal neovascularization (CNV) causes blindness patients with age-related macular degeneration (AMD). Here we report that increased IL10, not IL4 or IL13, senescent eyes activates STAT3 signalling induces alternative activation macrophages vascular proliferation. Targeted inhibition both IL10 receptor-mediated...
Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying pathogenic mechanisms in these diseases may offer global approaches for facilitating photoreceptor survival. We found that rod or cone photoreceptor-specific deletion nicotinamide phosphoribosyltransferase (Nampt), rate-limiting enzyme major NAD+ biosynthetic pathway beginning with nicotinamide, caused retinal degeneration. In both cases, we could rescue vision mononucleotide (NMN). Significantly, deficiency...
Significance FGF receptor (FGFR) signaling is thought to be essential for vascular development, homeostasis, and pathological angiogenesis. However, the in vivo requirements cellular targets of vasculature are not known. Here, we show that endothelial FGFR1 FGFR2 required homeostasis or physiological functions likely embryonic development. neovascularization after skin eye injury following retinal ischemia. These findings reveal a key requirement cell-autonomous FGFR tissue repair validate...
Age-related macular degeneration (AMD) is a major cause of blindness in the developed world. Oxidative stress and inflammation are implicated AMD, but precise mechanisms remain poorly defined. Carboxyethylpyrrole (CEP) an AMD-associated lipid peroxidation product. We previously demonstrated that mice immunized with CEP-modified albumin AMD-like degenerative changes outer retina. Here, we examined kinetics lesion development presence macrophages within interphotoreceptor matrix (IPM), between...
Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years age, is characterized by atrophic neurodegeneration or pathologic angiogenesis. Early AMD extracellular cholesterol-rich deposits underneath retinal pigment epithelium (RPE) called drusen in subretinal space drusenoid (SDD) that drive disease progression. However, mechanisms and SDD biogenesis remain poorly understood. Although human abnormalities cholesterol homeostasis shares...
Summary— A series of 155 patients who underwent nephrectomy for renal carcinoma between 1965 and 1985 at Manchester Royal Infirmary were analysed survival in relationship to presenting features, surgical staging histopathology. Univariate multivariate analyses carried out. Five‐year estimates stage 1 disease 81%, 2 65%, 3 39% 4 6%. An erythrocyte sedimentation rate (ESR) greater than 30 mm/h was associated with worse a history hypertension better survival. Renal vein invasion alone related...
Macrophage aging is pathogenic in diseases of the elderly, including age-related macular degeneration (AMD), a leading cause blindness older adults. However, role microRNAs, which modulate immune processes, regulating macrophage dysfunction and thereby promoting age-associated underexplored. Here, we report that microRNA-150 (miR-150) coordinates transcriptomic changes aged murine macrophages, especially those associated with aberrant lipid trafficking metabolism AMD pathogenesis. Molecular...
Glaucoma is the second leading cause of blindness worldwide. Physicians often use surrogate endpoints to monitor progression glaucomatous neurodegeneration. These approaches are limited in their ability quantify disease severity and due inherent subjectivity, unreliability, limitations normative databases. Therefore, there a critical need identify specific molecular markers that predict or measure Here, we demonstrate growth differentiation factor 15 (GDF15) associated with retinal ganglion...
Abstract The HIV/AIDS epidemic is drastically reducing the agricultural workforce of sub-Saharan Africa, threatening household food security and supply throughout region. Forests contribute to nutrition health therefore should be considered in efforts mitigate socioeconomic impact on rural agrarian households. Because little reference forests forest products exists literature concerned with coping mechanisms HIV/AIDS–affected households, we intend draw attention importance forest-based...
We have previously shown that the deletion of dystrophin Dp71 gene induces a highly permeable blood–retinal barrier (BRB). Given BRB breakdown is involved in retinal inflammation and pathophysiology many blinding eye diseases, here we investigated whether absence brings out vascular vessel loss by using specific Dp71-null mice. The expression endothelial growth factor (VEGF), quantified quantitative polymerase chain reaction enzyme-linked immunosorbent assay methods, was higher retina mice...
Chronic lymphocytic leukemia (CLL) is a mature B-cell neoplasm characterized by the expansion of CD5-positive lymphocytes in peripheral blood. While CLL most common type Western populations, disease rare Africans. Hence, clinical and laboratory data studies Sub Saharan populations have been limited. The aims this study were to analyze characteristics senegalese patients with at time diagnosis identify correlation between (Binet stage) age, gender, parameters chromosomal abnormalities. In...
Summary A prospective study comparing surgical and antibiotic treatment for recurrent tonsillitis in adults suggests that, whilst tonsillectomy is very effective, adequate medical provides an equally good alternative the majority of patients.
Histological examination of a tumor centered in the body pancreas 65–year-old Iranian man revealed it to have substantial component which osteoclast-like giant cells were set within stroma pleo-morphic mononuclear though other areas composed conventional adenocarcinoma. Immunocytochemistry was used investigate differentiation various tumor. The carcinoma usual type expressed epithelial antigens (EMA and cytokeratin). vimentin showed membrane staining with anti-LCA, common examples...
Patients with Duchenne muscular dystrophy (DMD) and mdx mice, devoid of dystrophin proteins, show altered ionic homeostasis. To clarify dystrophin's involvement in the central control osmotic stimuli, we investigated effect disruption Dp71, major form brain, on hypothalamoneurohypophysis system (HNHS) osmoregulatory response. Dp71 Dp140 are principal DMD gene products supraoptic nucleus (SON) neurohypophysis (NH). They present astrocyte pituicyte end-feet, suggesting both intrinsic...
RDD (Rosai Dorfman disease) is a rare and benign histiocytic proliferative disorder of unknown etiology. FNAC (Fine-needle aspiration cytology) useful reliable tool for the diagnosis RDD, as such, biopsy avoidable.