A5075585391- Historical and Religious Studies of Rome
- Renaissance and Early Modern Studies
- Chronic Lymphocytic Leukemia Research
- Language Development and Disorders
- Renaissance Literature and Culture
- Flowering Plant Growth and Cultivation
- Historical Influence and Diplomacy
- Reformation and Early Modern Christianity
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Reading and Literacy Development
- Plant Physiology and Cultivation Studies
- Architecture and Art History Studies
- Financial Crisis of the 21st Century
- Systemic Lupus Erythematosus Research
- Dutch Social and Cultural Studies
- Comparative and International Law Studies
- Historical and Cultural Studies of Poland
- Chemotherapy-induced cardiotoxicity and mitigation
- Classical Antiquity Studies
- Neurobiology of Language and Bilingualism
- Medieval European History and Architecture
- Cancer Treatment and Pharmacology
- Chronic Myeloid Leukemia Treatments
- Plant tissue culture and regeneration
Immuneering (United States)
2024
Sanquin
1991-2023
Institute of Wetland Research
2021-2023
Rijksmuseum
2019-2022
University of Groningen
2002-2022
University of Bergen
2017-2022
Janssen (United States)
2013-2020
Hersenstichting
2018-2020
University of Amsterdam
1999-2018
Amsterdam UMC Location University of Amsterdam
1996-2018
To compare the incidence of anti-double-stranded DNA (anti-dsDNA) antibodies in rheumatoid arthritis (RA) patients receiving either single or multiple doses a chimeric anti-tumor necrosis factor alpha (anti-TNFalpha) antibody placebo infusions, with without methotrexate, open-label, randomized, placebo-controlled trials.Multiple sera obtained from 156 before and after treatment infliximab 37 treated infusions were tested for anti-dsDNA by 3 methods: Crithidia luciliae indirect...
SUMMARY Shortage of teachers is one the major challenges facing teaching profession. One its causes high proportion dropout in initial teacher education and during start career. Since 1995, a nation-wide project has been underway Netherlands, aiming at decrease by incorporating an intensive practice period final year training programme. An evaluation shows that shock resulting rate were indeed reduced. Relevant factors seem to be degree which student accepted deployed school, supervision...
<h3>Introduction</h3> Gastro-oesophageal reflux occurs twice as much during transient lower oesophageal sphincter relaxations (TLOSRs) in patients with gastro-oesophageal disease (GORD) compared to healthy volunteers (HVs). Our aim was assess whether the localisation of postprandial acid pocket and its interaction a hiatal hernia (HH) play role occurrence acidic TLOSRs. <h3>Methods</h3> Ten HVs 22 GORD (12 HH<3 cm (s-HH), 10 HH≥3 (l-HH)) were studied. The squamocolumnar junction...
Abstract Background: While narrative tasks have proven to be valid measures for detecting language disorders, measuring communicative skills and predicting future academic performance, research into the comparability of different has shown that outcomes are dependent on type task used. Although many studies differences touch upon fact place differential demands cognitive abilities like auditory attention memory, few related specific these abilities. Examining this relation is especially...
The absorption, metabolism, and excretion of ibrutinib were investigated in healthy men after administration a single oral dose 140 mg <sup>14</sup>C-labeled ibrutinib. mean (S.D.) cumulative radioactivity the was 7.8% (1.4%) urine 80.6% (3.1%) feces with <1% excreted as parent Only oxidative metabolites very limited compound detected feces, this indicated that completely absorbed from gastrointestinal tract. Metabolism occurred via three major pathways (hydroxylation phenyl (M35),...
Based on ibrutinib pharmacokinetics and potential sensitivity towards CYP3A4‐mediated drug–drug interactions (DDIs), a physiologically based pharmacokinetic approach was developed to mechanistically describe DDI with various CYP3A4 perpetrators in healthy men under fasting conditions. These models were verified using clinical data for ketoconazole (strong inhibitor) used prospectively predict confirm the inducing effect of rifampin inducer); DDIs mild (fluvoxamine, azithromycin) moderate...
Abstract Ibrutinib ( PCI ‐32765), a potent covalent inhibitor of Bruton's tyrosine kinase, has shown efficacy against variety B‐cell malignancies. Given the prominent role CYP 3A in ibrutinib metabolism, effect coadministration perpetrators with was evaluated healthy adults. (120 mg [Study 1, fasted], 560 [studies 2 (fasted), and 3 (nonfasted)]) given alone ketoconazole 1; 400 q.d.], rifampin 2; 600 grapefruit juice [ GFJ , Study 3]. Lower doses were used together inhibitors 1: 40 mg; 3: 140...
The cell membrane is protected against lipid peroxidation through endogenous antioxidants such as the soluble alpha-tocopherol. anesthetic agent propofol (2,6-diisopropylphenol) has a chemical structure which similar to alpha-tocopherol, since it also contains phenolic OH-group. transient protection of GSH in control liver microsomes not observed deficient Introducing (2 and 5 microM) restored protective effect GSH. Similar GSH-protective did occur previously heated microsomes. These results...
To assess ibrutinib pharmacokinetics under fasted and fed conditions, impact of food-intake timing, the safety tolerability.Three studies were analyzed. Study 1 was a randomized, open-label, single-dose, four-way crossover study in 44 healthy participants. 2 repeat-dose 16 patients with previously treated chronic lymphocytic leukemia (CLL). Ibrutinib dose 420 mg both studies. 3 an sequential to effect standard breakfast on 560 eight participants.Administration single-dose fasting conditions...
The Smith-Lemli-Opitz syndrome (SLOS) is caused by deficient Δ7-dehydrocholesterol reductase, which catalyzes the final step of cholesterol biosynthetic pathway, resulting in low and high concentrations its direct precursors 7-dehydrocholesterol (7DHC) 8DHC. We hypothesized that i) 7DHC 8DHC accumulation contributes to poor outcome SLOS patients ii) blood exchange transfusions with hydroxymethylglutaryl (HMG)-CoA reductase inhibition would improve precursor-to-cholesterol ratio may clinical...
Aims Ibrutinib, an inhibitor of Bruton's tyrosine kinase, is used in the treatment mantle cell lymphoma or chronic lymphocytic leukaemia. Ibrutinib undergoes extensive rapid oxidative metabolism mediated by cytochrome P450 3A both at level first pass and clearance, which might result low oral bioavailability. The present study was designed to investigate absolute bioavailability (F) ibrutinib fasting fed state assess effect grapefruit juice (GFJ) on systemic exposure order determine fraction...