A5065796071- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Neurogenetic and Muscular Disorders Research
- Advanced Neuroimaging Techniques and Applications
- Hip disorders and treatments
- Lower Extremity Biomechanics and Pathologies
- Spinal Dysraphism and Malformations
- Birth, Development, and Health
- Occupational Health and Performance
- Balance, Gait, and Falls Prevention
- Nerve Injury and Rehabilitation
- Cerebrovascular and Carotid Artery Diseases
- Family and Disability Support Research
- Neurological disorders and treatments
- Total Knee Arthroplasty Outcomes
- Motor Control and Adaptation
- Amino Acid Enzymes and Metabolism
- Tendon Structure and Treatment
- Retinopathy of Prematurity Studies
- Acute Ischemic Stroke Management
- Folate and B Vitamins Research
Medical University of South Carolina
2021-2024
Medical University of Graz
2016-2023
University of Bern
1994
Early detection of changes at the muscular level before a contracture develops is important to gain knowledge about development deformities in individuals with spasticity. However, little information available muscle morphology children spastic diplegic cerebral palsy (CP) without or equinus gait. Therefore, aim this study was compare gastrocnemius medialis (GM) and Achilles tendon architecture adolescents CP gait that typically developing (TD) children.Two-dimensional ultrasonography used...
Abstract This study investigated the effect of using subthreshold vibration as a peripheral sensory stimulation during therapy on cortical activity. Secondary analysis pilot triple-blinded randomized controlled trial. Twelve chronic stroke survivors underwent 2-week upper-extremity task-practice therapy. Half received vibratory their paretic wrist (treatment group) and other half did not (control). EEG connectivity event-related de-/resynchronization for sensorimotor network hand grip were...
Integrity of the corticospinal tract (CST) is an important biomarker for upper limb motor function following stroke. However, when structurally compromised, other tracts may become relevant compensation or recovery function.
Purpose : The purpose of this study was to investigate the effects functional progressive resistance training (PRT) and high-intensity circuit (HICT) on mechano-morphological properties plantar flexor muscle-tendon unit in children with spastic cerebral palsy. Methods Twenty-two (12.8 [2.6] y old, Gross Motor Function Classification System levels I/II = 19/3) were randomly assigned either a PRT group or an HICT group. interventions consisted lower limb exercises, which performed at home 3...
Abstract Background Post-stroke hand impairment is prevalent and persistent even after a full course of rehabilitation. Hand diminishes stroke survivors’ abilities for activities daily living independence. One way to improve treatment efficacy augment therapy with peripheral sensory stimulation. Recently, novel stimulation, TheraBracelet, has been developed in which imperceptible vibration applied during task practice through wrist-worn device. The objective this trial determine if combining...
BACKGROUND: Uncertain prognosis presents a challenge for therapists in determining the most efficient course of rehabilitation treatment individual patients. Cortical Sensorimotor network connectivity may have prognostic utility upper extremity motor improvement because integrity communication within sensorimotor forms basis neuroplasticity and recovery. OBJECTIVE: To investigate if pre-intervention predicts post-stroke following therapy. METHODS: Secondary analysis pilot triple-blind...
Glutathione (GSH) plays an important role in the detoxification of reactive metabolites oxygen and xenobiotics as a source cysteine. Since several clinical situations characterized by low circulating intracellular GSH have been identified, there is growing interest pharmacological interventions to correct deranged sulfhydril status. Therefore, systemic bioavailability orally administered glutathione monoethyl ester (GSHE) was examined rat. Following intraduodenal administration 0.5 mmol/kg...
Abstract Knowledge regarding the neural origins of distinct upper extremity impairments may guide choice interventions to target structures responsible for specific impairments. This cross‐sectional pilot study investigated whether different brain networks explain aspects hand grip performance in stroke survivors. In 22 chronic survivors, was characterized as strength, reaction, relaxation times, and control force magnitude direction. addition, their structural connectomes were constructed...
Stroke leads to complex chronic structural and functional brain changes that specifically affect motor outcomes. The brain-predicted age difference (brain-PAD) has emerged as a sensitive biomarker. Our previous study showed higher global brain-PAD associated with poorer function post-stroke. However, the relationship between local stroke lesion load, regional age, impairment remains unclear.
Hand sensorimotor deficits often result from stroke, limiting the ability to perform daily living activities. Sensorimotor are heterogeneous among stroke survivors. Previous work suggests a cause of hand is altered neural connectivity. However, relationships between connectivity and specific aspects control have seldom been explored. Understanding these important for developing personalized rehabilitation strategies improve individual patients’ and, thus, outcomes. Here, we investigated...
Abstract Background Functional task performance requires proper control of both movement and force generation in three-dimensional space, especially for the hand. Control three dimensions, however, is not explicitly treated current physical rehabilitation. To address this gap treatment, we have developed a tool to provide visual feedback on finger force. Our objective examine effectiveness training with restore hand function stroke survivors. Methods Double-blind randomized controlled trial....
Cerebral palsy (CP) is the most common motor and movement disability in childhood. The mechano-morphological alterations of spastic muscle itself as well functional limitations CP are documented. However, relationship between tendon properties tests remains unknown. aim this study was to explore performance children with CP. This included retrospective data from 22 cerebral a mean age 12.8 years (19 GMFCS I/3 GMFC II, 15 male/7 female, 8 unilateral involved/14 bilateral)....
Abstract Date Presented Accepted for AOTA INSPIRE 2021 but unable to be presented due online event limitations. Uncertain poststroke prognosis makes it difficult OTs develop personalized treatments their patients. This study evaluated electroencephalography (EEG) as a predictor of individual response rehabilitation program. Results demonstrate the potential EEG predict patients’ responsiveness an upper extremity intervention. These findings may promote individualized treatment and encourage...