A5051834966- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacteriophages and microbial interactions
- Salmonella and Campylobacter epidemiology
- Infectious Diseases and Tuberculosis
- Digital Imaging for Blood Diseases
- Zoonotic diseases and public health
- Parasite Biology and Host Interactions
- Rabies epidemiology and control
- Viral gastroenteritis research and epidemiology
- Biosensors and Analytical Detection
- Virology and Viral Diseases
- Parasites and Host Interactions
- Poxvirus research and outbreaks
- Antimicrobial Resistance in Staphylococcus
- COVID-19 diagnosis using AI
- Microbial infections and disease research
- Cancer therapeutics and mechanisms
- Vibrio bacteria research studies
- Viral Infections and Outbreaks Research
- Immunodeficiency and Autoimmune Disorders
- Helminth infection and control
- Bacillus and Francisella bacterial research
Lilongwe University of Agriculture and Natural Resources
2022-2025
Hokkaido University
2020-2023
University of Zambia
2017
Background: Shigella species are the leading cause of human shigellosis. In Zambia, more than 30% children experiencing diarrhea infected with species. The increasing resistance to recommended therapy is great concern. Therefore, this study investigated antibiotic profiles and phenotypic genotypic characteristics isolates at largest referral hospital in Zambia. Methodology: Of forty-eight archived presumptive isolates, thirty-two were serologically confirmed subjected antimicrobial...
The emergence of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) is a threat to TB control programs in developing countries such as Zambia. Studies Zambia have applied molecular techniques understand drug-resistance-associated mutations, circulating lineages and transmission patterns multi-drug-resistant (MDR) Mycobacterium tuberculosis. However, none has reported genotypes mutations associated with pre-XDR TB. This study characterized 63 M. strains from the University Teaching...
Methicillin-resistant Staphylococcus aureus (MRSA) have been a major public health concern in humans. Among MRSA, livestock-associated (LA)-MRSA strains always associated with exposure to livestock or their products and emerged different countries globally. Although studies identified LA-MRSA from healthy pigs pork Thailand, prevalence slaughtered is still unknown. In addition, there are few reports on the epidemiology molecular characteristics of Thailand. Hence, this first report...
Bovine tuberculosis (TB) caused by Mycobacterium bovis is a significant health threat to cattle and zoonotic for humans in many developing countries. Rapid accurate detection of M . fundamental controlling the disease animals humans, proper treatment patients as one first-line anti-TB drug, pyrazinamide, ineffective against Currently, there are no rapid, simplified low-cost diagnostic methods that can be easily integrated use Here, we report development loop-mediated isothermal amplification...
ABSTRACT Quinolone-resistant nontyphoidal Salmonella , one of the prominent pathogens causing acute gastroenteritis, has become a public health concern globally. The World Health Organization ranked fluoroquinolone-resistant as high-priority pathogen for researching and developing new antibiotics. WQ-3034 WQ-3154 are relatively synthetic fluoroquinolones with distinctive structures. 6-amino-3,5-difluoropyridine-2-yl at R 1 3-hydroxyazetidinyl 7 addition chlorine atom 8 . similar basic...
Bovine tuberculosis (bTB) is an infectious disease with significant socioeconomic, animal, and public health impacts. However, the prevalence of bTB remains largely unclear in Malawi due to a paucity information. Additionally, existence multiple risk factors postulated enhance transmission animals. A cross-sectional survey estimate bTB, animal characteristics identify associated was conducted from slaughtered cattle at three major regional abattoirs (southern, central northern regions)...
The lack of quick, accurate, and low-cost detection methods has hindered the active control strategies for bovine tuberculosis (bTB) in resource-limited countries with a high burden disease. We developed dry loop-mediated isothermal amplification (LAMP) assay rapid specific Mycobacterium bovis, principal causative agent bTB, evaluated efficacy using suspected bTB samples collected during routine meat inspection at major regional abattoirs Malawi. Template genomic DNA was extracted directly...
Aims: WQ-3810 has strong inhibitory activity against Salmonella and other fluoroquinolone-resistant pathogens. The unique potentiality of this is attributed to 6-amino-3,5-difluoropyridine-2-yl at R1 group. aim study was examine its derivatives WQ-3334 WQ-4065 as the new drug candidate for wild-type that carrying QnrB19. Materials Methods: half maximal concentrations (IC50s) WQ-3810, (Br atom in place methyl group R8), (6-ethylamino-3,5-difluoropyridine-2-yl R1) presence or absence QnrB19...
Globally, tuberculosis (TB) is a major cause of death due to antimicrobial resistance. Mycobacterium CAS1-Kili strains that belong lineage 3 (Central Asian Strain, CAS) were previously implicated in the spread multidrug-resistant (MDR)-TB Lusaka, Zambia. Thus, we investigated recent transmission those by whole-genome sequencing (WGS) with Illumina MiSeq platform. Twelve MDR isolates clustered traditional methods (MIRU-VNTR and spoligotyping) used. A total 92% (11/12) belonged cluster (≤12...
Bovine tuberculosis (bTB) is a neglected disease that affects cattle and humans. The burden of bTB higher in developing countries as compared to industrialized countries. reasons behind this discrepancy include the fact control measures, such testing slaughter infected pasteurization milk, are not usually practised largely because their high cost. To improve our understanding countries, molecular typing studies essential, particular terms transmission dynamics, infection sources knowledge...
The prevalence of bovine tuberculosis (bTB), an infectious disease with significant socioeconomic, animal, and public health impacts, remains largely unclear in Malawi due to a paucity information. Additionally, the existence multiple risk factors is postulated enhance bTB transmission. A cross-sectional study estimate bTB, animal characteristics identify associated was conducted from slaughtered cattle at three major regional abattoirs (southern, central northern regions) Malawi. Out total...
Abstract Introduction Rabies is a neglected tropical disease that endemic to Malawi, killing almost 500 people every year. Domestic dogs are implicated as the main reservoir for rabies. However, there limited capacity detect canine rabies in country, particularly urban areas where high dog densities. The Lilongwe Society Protection and Care of Animals designed implemented community-based surveillance (CBRS) city between January June 2020. Objectives This study assessed effectiveness CBRS...