A5053774439- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Clusterin in disease pathology
- Dermatology and Skin Diseases
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- COVID-19 Impact on Reproduction
- Kawasaki Disease and Coronary Complications
- Plant Parasitism and Resistance
- Adipokines, Inflammation, and Metabolic Diseases
- Urticaria and Related Conditions
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- S100 Proteins and Annexins
- Plant Stress Responses and Tolerance
- Venous Thromboembolism Diagnosis and Management
- SARS-CoV-2 detection and testing
- Traumatic Ocular and Foreign Body Injuries
- Plant-Microbe Interactions and Immunity
- Biomarkers in Disease Mechanisms
Carilion Clinic
2024
Virginia Tech
2024
Massachusetts General Hospital
2021-2023
National Patient Safety Foundation
2022
Yale University
2018
SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and death in a minority of patients. Although severe COVID-19 disease is linked exuberant inflammation, how triggers inflammation not understood. Monocytes macrophages are sentinel immune cells the blood tissue, respectively, sense invasive infection form inflammasomes activate caspase-1 gasdermin D (GSDMD) pores, leading inflammatory (pyroptosis) processing release IL-1 family cytokines, potent mediators....
SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and death in some patients. Although severe COVID-19 disease is linked exuberant inflammation, how triggers inflammation not understood. Monocytes are sentinel blood cells sense invasive infection form inflammasomes activate caspase-1 gasdermin D (GSDMD) pores, leading inflammatory (pyroptosis) processing release of IL-1 family cytokines, potent mediators. Here we show ~10% monocytes patients dying infected...
Sepsis is a life-threatening condition caused by dysregulated host response to infection. Despite continued efforts understand the pathophysiology of sepsis, no effective therapies are currently available. While singular components aberrant immune have been investigated, comprehensive studies linking different data layers lacking. Using an integrated systems immunology approach, we evaluated neutrophil phenotypes and concomitant changes in cytokines metabolites patients with sepsis. Our...
Atopic Dermatitis (AD) is one of the most common inflammatory skin conditions. AD generally characterized by eczematous and pruritic lesions, although it can present differently between individuals. There are multiple comorbidities for AD, including asthma, food allergies, ocular disorders such as conjunctivitis. Common treatments include topical corticosteroids, calcineurin inhibitors, injectable biologic medications. However, all these medications pose risks that may deter some patients....
Abstract Sepsis is a life-threatening condition caused by an aberrant immune response to infection and subsequent organ dysfunction. Further, due shared mechanisms such as severe inflammation endothelial dysfunction, sepsis remains the most common etiology in acute respiratory distress syndrome (ARDS) patients. Despite multiple efforts identify distinct signature support development of new therapeutics, significant unmet clinical need. While singular components dysregulated have been...
Abstract Sepsis is a life-threatening condition caused by dysregulated host response to infection. Despite continued efforts understand the pathophysiology of sepsis, no effective therapies are currently available. While singular components aberrant immune have been investigated, comprehensive studies linking different data layers lacking. Using an integrated systems immunology approach, we evaluated neutrophil phenotypes and concomitant changes in cytokines metabolites sepsis patients. Our...