Mihail–Lucian Pascu

ORCID: 0000-0003-1151-9345
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About
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Research Areas
  • Photodynamic Therapy Research Studies
  • Laser Design and Applications
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Laser Applications in Dentistry and Medicine
  • Photochemistry and Electron Transfer Studies
  • bioluminescence and chemiluminescence research
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Semiconductor Lasers and Optical Devices
  • Porphyrin and Phthalocyanine Chemistry
  • Solid State Laser Technologies
  • Analytical Chemistry and Sensors
  • Diagnosis and Treatment of Venous Diseases
  • Nanoplatforms for cancer theranostics
  • Bioactive Compounds and Antitumor Agents
  • Laser-induced spectroscopy and plasma
  • Laser-Matter Interactions and Applications
  • Ocular and Laser Science Research
  • Essential Oils and Antimicrobial Activity
  • Pickering emulsions and particle stabilization
  • Nonlinear Dynamics and Pattern Formation
  • Cancer therapeutics and mechanisms
  • Photonic and Optical Devices
  • Water Quality Monitoring and Analysis
  • Laser Material Processing Techniques
  • Analytical chemistry methods development

National Institute for Laser Plasma and Radiation Physics
2015-2024

Academy of Romanian Scientists
2020-2024

University of Bucharest
2014-2023

Iscare I.V.F
2016

Keio University
2015

Semmelweis University
2015

University of Trieste
2015

Centro Laser
2015

University of Florence
2015

European Commission
2013

This paper presents a spectroscopic study of emulsions generated with laser-assisted device. Fourier transform infrared (FTIR), Raman and UV–Vis–NIR reflectance spectra emulsions, recorded before after exposure to laser radiation were used characterize the effect irradiation. The also comparison between calculated IR experimental FTIR an emulsion’s components. measurements allowed identification absorption bands specific each emulsions’ Moreover, it enabled observation destabilization...

10.3390/molecules25071729 article EN cc-by Molecules 2020-04-09

We present the four key areas of research-preprocessing, volume conductor, forward problem, and inverse problem-that affect performance EEG MEG source imaging. In each area we identify prominent approaches methodologies that have open issues warranting further investigation within community, challenges associated with certain techniques, algorithms necessitating clarification their implications. More than providing definitive answers aim to important in quest localization.

10.1155/2009/656092 article EN cc-by Computational Intelligence and Neuroscience 2009-01-01

Space-charge amplification of the direct and indirect ionization resulting from photoabsorption in alkali-metal vapor is shown to provide a useful complement conventional techniques absorption spectroscopy. Because its inherently greater sensitivity, this technique particularly spectroscopic applications involving weak transitions such as those highly excited states or absorptive low population. This paper reports use extend prior measurements oscillator strengths...

10.1103/physreva.8.1666 article EN Physical review. A, General physics 1973-10-01

This paper reports the observation of two-photon ionization molecular cesium as a continuous function laser wavelength in 6200-6600-\AA{} region with tunable dye having 0.18-${\mathrm{Cm}}^{\ensuremath{-}1}$ linewidth. To author's knowledge, it serves to illustrate first extension neutral species important techniques resonant multiphoton photodetachment spectroscopy. The resulting photoionization spectrum is intepreted terms vibrational structure intermediate state.

10.1103/physreva.8.2197 article EN Physical review. A, General physics 1973-10-01

Introduction Phenothiazines when exposed to white light or UV radiation undergo a variety of reactions that result in degradation parental compound and formation new species. This process is slow may be sped up with exposure high energy such as produced by laser. Methods Varying concentrations Chlorpromazine Hydrochloride (CPZ) (2–20 mg/mL distilled water) were 266 nm laser beam (time intervals: 1–24 hrs). At distinct intervals the irradiation products evaluated spectrophotometry between...

10.1371/journal.pone.0055767 article EN cc-by PLoS ONE 2013-02-06

Abstract Antibiotic resistance became an increasing risk for population health threatening our ability to fight infectious diseases. The objective of this study was evaluate the activity laser irradiated thioridazine (TZ) against clinically-relevant bacteria in view antibiotic resistance. TZ ultrapure water solutions (1–240 min) with 266 nm pulsed radiation. Irradiated were characterized by UV–Vis and FTIR absorption spectroscopy, thin layer chromatography, laser-induced fluorescence,...

10.1038/s41598-020-74752-z article EN cc-by Scientific Reports 2020-10-22

The study reports an investigation of the photoproducts obtained by exposure chlorpromazine hydrochloride in ultrapure water (concentration 2 mg/mL) to a 266-nm laser beam fourth harmonic generation from Nd:YAG (6-ns full time width at half maximum, 10-Hz pulse repetition rate). were analyzed steady-state UV-Vis absorption, laser-induced fluorescence, Fourier transform infrared spectroscopy, and liquid chromatography–tandem time-of-flight mass spectroscopy. Two figures showing pathways that...

10.1117/1.jbo.20.5.051002 article EN Journal of Biomedical Optics 2014-11-03

Objective To assess the efficacy and safety of a new method clearing varicose veins in long term. It consists applying long-pulsed Nd:YAG laser following injection polidocanol microfoam, two consecutive sessions, treating both legs full each session. Method Randomized, Polidocanol-controlled, blind evaluation clinical trial comparing results between 79 treated with Polidocanol 517 + Laser. Photographs were taken preoperatively at three months, years after treatment, as well patient...

10.1177/0268355513502786 article EN Phlebology The Journal of Venous Disease 2013-08-29

Ciprofloxacin is one of the most prescribed antibiotics in treating bacterial infections, becoming an important pollutant wastewaters. Moreover, ciprofloxacin hard to be destroyed by conventional water treatment processes; therefore, efficient treatments destroy it are needed decontamination. This study offers insights into performance 266 nm laser beams on photodegradation ciprofloxacin. An Nd:YAG was used that emitted at energy 6.5 mJ (power 65 mW) and solutions were irradiated up 240 min....

10.3390/molecules26082324 article EN cc-by Molecules 2021-04-16

Abstract It was demonstrated that comparison of the autofluorescence spectra induced with laser radiation in ultraviolet and visible allows identification brain tumor tissues normal as well difference between them. The measurements were performed on homogenates to ensure an optimal reproducibility results. We conclude samples are close those measured for tissues, but there differences them allow distinguishing from tissue. One is each pair tumor/normal tissue samples, peak shifted respect...

10.1002/ar.21034 article EN The Anatomical Record 2009-11-26

Whereas exposure of combinations a phenothiazine and bacterium to incoherent UV increases the activity phenothiazine, alone does not yield an increase its activity. Because laser beam energy is greater than that produced by sources, phenothiazines specific lasers may molecules with altered activities over unexposed parent. Chlorpromazine, thioridazine promethazine active against bacteria were exposed two distinct for varying periods time. Absorption fluorescence spectra conducted prior...

10.2174/157489111796064515 article EN Recent Patents on Anti-Infective Drug Discovery 2011-05-01

In this paper, laser beam resonant interaction with pendant microdroplets that are seeded a dye (Rhodamine 6G (Rh6G)) water solution or oily Vitamin A emulsion Rhodamine in is investigated through fluorescence spectra analysis. The excitation made the second harmonic generated emitted by pulsed Nd:YAG system at 532 nm. containing exhibit an enhanced signal. This effect can be explained as being due to scattering of light sub-micrometric drops and spherical geometry droplet. droplet acts...

10.1063/1.4913648 article EN Biomicrofluidics 2015-01-01

Nowadays, antibiotic resistance has become increasingly common, triggering a global health crisis, immediately needing alternative, including repurposed drugs with potent bactericidal effects. We demonstrated that chlorpromazine aqueous solutions exposed to laser radiation exhibited visible activity against various microorganisms. The aim of this study was investigate the quantitative antimicrobial in non-irradiated and 4-h irradiated form. Also, we examined effect both impregnated on cotton...

10.3390/coatings10121230 article EN Coatings 2020-12-16

Varying concentrations of Chlorpromazine Hydrochloride (CPZ) were exposed to a 266 nm laser beam for varying periods time ranging from 4 24 hrs and the products irradiation evaluated activity against panel bacteria that consisted representatives Gram-positives Gram-negatives expressed different degrees efflux pump activity, compared parental unexposed compound with prolonged irradiation.Whereas antibacterial product Staphylococcus aureus Escherichia coli strains was many folds greater, no...

10.4172/2167-0501.1000109 article EN Biochemistry & Pharmacology Open Access 2013-01-01
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