Abstract Surgical removal of malignant tumors is a mainstay in controlling most solid cancers. However, surgical insult also increases the risk tumor recurrence and metastasis. Tissue trauma activates innate immune system locally systemically, mounting an inflammatory response. Platelets neutrophils are two crucial players early response that heals tissues, but their actions may contribute to cancer cell dissemination distant Here we report stress–activated platelets enhance formation...

Abstract Semi‐hydrogenation of acetylene to ethylene is an important process purify streams in industry. However, among current approaches reported the literature, high selectivity has been generally achieved at expense activity. Herein, we show that a Ga 2 O 3 coating Ag@Pd core–shell bimetallic nanoparticle catalysts, allows improvement much greater extent than monometallic Pd nanoparticles, while preserving remarkable intrinsic activity, approximately 50 times higher benchmark catalyst 1...

Metal single-atom catalysts (SACs) have received significant attention in the catalysis field due to maximized atom efficiency and their unique catalytic properties. The support could prominent influences on performance. However, effect metal SACs has been much less explored. We found that Pd1/graphene catalyst exhibited remarkably higher activity than Pd1/C3N4 both reactions, but alkene selectivity showed a different trend. In hydrogenation of acetylene, considerably ethylene was observed...

Sirtuin 6 (SIRT6) can function as a tumor suppressor by suppressing aerobic glycolysis and apoptosis resistance. However, the negative effect of SIRT6 on cellular senescence implies that it may also have potential to promote development. Here we report upregulation expression was required for transforming growth factor (TGF)-β1 H2O2/HOCl reactive oxygen species (ROS) tumorigenicity hepatocellular carcinoma (HCC) cells. Transforming factor-β1/H2O2/HOCl could upregulate in HCC cells inducing...

// Qiang Ding 1 , Yujia Xia Shuping Panpan Lu Liang Sun 2 Mei Liu Department of Gastroenterology, Tongji Hospital, Medical College, Huazhong University Science and Technology, Wuhan, Hubei Province, China The Central Hospital Correspondence to: Liu, e-mail: fliumei@126.com Keywords: CXCR3/CXCL9, CD133+ liver cancer cells, metastasis, adhesion Received: October 29, 2015 Accepted: January 28, 2016 Published: February 13, ABSTRACT Metastasis is closely linked to tumor microenvironment, in which...

Pyridine formation with oxime acetates as the building blocks under metal-free conditions is described. Ammonium iodide has proved to be a highly efficient promoter for N-O bond reduction and subsequent condensation reactions, whereby it played dual-function role in transformation. While three-component reaction of acetates, benzaldehydes, 1,3-dicarbonyls proceeded well assistance stoichiometric amount ammonium iodide, oximes acroleins was enabled by using catalytic initiator afford...

Abstract Infertility is a complex multifactorial disease that affects up to 10% of couples across the world. However, many mechanisms infertility remain unclear due lack studies based on systematic knowledge, leading ineffective treatment and/or transmission genetic defects offspring. Here, we developed an database provide comprehensive resource featuring various factors involved in infertility. Features current IDDB version were manually curated as follows: (i) total 307...

Computational pathology, utilizing whole slide images (WSIs) for pathological diagnosis, has advanced the development of intelligent healthcare. However, scarcity annotated data and histological differences hinder general application existing methods. Extensive histopathological robustness self-supervised models in small-scale demonstrate promising prospects developing foundation pathology models. Here we show BEPH (BEiT-based model Pre-training on Histopathological image), a that leverages...

Metastasis contributes to the poor prognosis of hepatocellular carcinoma (HCC). Anoikis resistance and orientation chemotaxis are two important sequential events in tumor cell metastasis. The process metastasis is known be regulated by AEG-1, an oncogene that plays a critical role metastasis, though effects this on anoikis HCC cells currently unknown. To directly assess AEG-1 these processes, we up-regulated expression via exogenous transfection SMMC-7721 cells, which express low endogenous...

SWELL1 was recently demonstrated to be an indispensable part of the volume-regulated anion channel (VRAC). VRAC is reported participate in cell proliferation, survival, and migration. However, correlation between hepatocellular carcinoma (HCC) remains poorly-understood. In this study, we tried explore role HCC.Immunohistochemistry quantitative real-time-PCR (qRT-PCR) used measure expression HCC samples obtained from patients with HCC. The effects on apoptosis, metastasis were analysed by...

Accurate treatment outcome assessment is crucial in clinical trials. However, due to the image-reading subjectivity, there exist discrepancies among different radiologists. The situation common liver cancer complexity of abdominal scans and heterogeneity radiological imaging manifestations subtypes. Therefore, we developed a deep learning-based detect-then-track pipeline that can automatically identify lesions from 3D CT then longitudinally track target lesions, thereby providing evaluation...

// Jingmei Liu 1 , Ping Han Mengke Li Wei Yan Jin Jiqiao 2 Jiayi He Tu Yujia Xia Zhenzhen Zhou Gong Mei Qiang Ding Dean Tian Department of Gastroenterology, Tongji Hospital Medical College, Huazhong University Science and Technology, Wuhan, Hubei Province, China Ultrasound, Correspondence to: Tian, e-mail: datian@tjh.tjmu.edu.cn Keywords: HRC, Focal Adhesion Turnover, SATB1, Hepatocellular carcinoma, Metastasis Received: November 03, 2014 Accepted: January 07, 2015 Published: 22, ABSTRACT...

Abstract Computational pathology, utilizing whole slide image (WSI) for pathological diagnosis, has advanced the development of intelligent healthcare. However, scarcity annotated data and histological differences hinder general application existing methods. Extensive histopathological robustness self-supervised models in small-scale demonstrate promising prospects developing foundation pathology models. Due to need deployment, lightweight also be developed. In this work, we propose BEPH (...

Liver fibrosis is a worldwide clinical issue. Activation of hepatic stellate cells (HSCs) the central event during liver fibrosis. We investigated role SATB1 in HSC activation and fibrogenesis. The results show that expression reduced activation. Additionally, inhibits activation, proliferation, migration, collagen synthesis. Furthermore, CTGF, pro-fibrotic agent, also significantly inhibited by through Ras/Raf-1/MEK/ERK/Ets-1 pathway. In vivo, deactivates HSCs attenuates TAA-induced...

Abstract Objectives To develop a deep learning model combining CT scans and clinical information to predict overall survival in advanced hepatocellular carcinoma (HCC). Methods This retrospective study included immunotherapy-treated HCC patients from 52 multi-national in-house centers between 2018 2022. A multi-modal prognostic using baseline the first follow-up images 7 variables was proposed. convolutional-recurrent neural network (CRNN) developed extract spatial-temporal automatically...

Accurate treatment response assessment using serial CT scans is essential in oncological clinical trials. However, oncologists' following the Response Evaluation Criteria Solid Tumors (RECIST) guideline subjective, time-consuming, and sometimes fallible. Advanced liver cancer often presents multifocal hepatic lesions on imaging, making accurate characterization more challenging than with other malignancies. In this work, we developed a tumor volume guided comprehensive objective evaluation...

Astrocyte‑elevated gene‑1 (AEG‑1) has been reported to be associated with cancer progression in various types of human cancers, including liver cancer. However, date, the molecular mechanism AEG‑1 action on growth cells poorly elucidated. The present study aimed investigate effect proliferation and apoptosis role IL‑6 this process using HepG2 hepatoma cell line. shRNAs targeting were used silence expression AEG‑1. effects detected by 3‑(4, 5‑dimethylthiazol‑2‑yl)‑2, 5‑diphenyltetrazolium...

To study the effect of anandamide (AEA) on necrosis in HepG2 cells and to explore role AEA progression liver cancer.Localization fatty acid hydrolytic enzyme (FAAH), cannabinoid receptors 1(CB1) 2 (CB2) proteins was detected L02 using immunofluorescence. were treated with different concentrations methyl-beta-cyclodextrin, rates examined by PI stain. Meanwhile, expression levels FAAH, CB1 CB2 receptor proteins, as well P38 mitogen-activated protein kinase (p-P38 MAPK) c-Jun-NH2-terminal...

Readily available arylacetic acids and phenylalanines were exploited to be efficient C1 building blocks in thiazo-annulation reactions with elemental sulfur.

Abstract Semi‐hydrogenation of acetylene to ethylene is an important process purify streams in industry. However, among current approaches reported the literature, high selectivity has been generally achieved at expense activity. Herein, we show that a Ga 2 O 3 coating Ag@Pd core–shell bimetallic nanoparticle catalysts, allows improvement much greater extent than monometallic Pd nanoparticles, while preserving remarkable intrinsic activity, approximately 50 times higher benchmark catalyst 1...