A5100338579- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Mental Health and Psychiatry
- interferon and immune responses
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Mitochondrial Function and Pathology
- Psychosomatic Disorders and Their Treatments
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
- Amoebic Infections and Treatments
- Sarcoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Telomeres, Telomerase, and Senescence
- Action Observation and Synchronization
- Blood Pressure and Hypertension Studies
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Radiation Therapy and Dosimetry
- Health Promotion and Cardiovascular Prevention
- T-cell and B-cell Immunology
- Heat shock proteins research
- Chronic Obstructive Pulmonary Disease (COPD) Research
Yonsei University
2012-2025
CHA Bundang Medical Center
2024
CHA University
2024
Severance Hospital
2021-2024
Yonsei University College of Dentistry
2011
Abstract Immune checkpoint molecule programmed death-ligand 1 (PD-L1) is overexpressed in cancer cells and imparts resistance to therapy. Although membrane PD-L1 has been targeted for immune therapy, nuclear was reported confer resistance. Therefore, it important regulate the PD-L1. The mechanisms underlying therapeutic efficacy of targeting have not well-established. Cellular senescence considered a pivotal mechanism prevent progression, recently, inhibition shown be involved cell...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor survival rate, largely due to the lack of early diagnosis. Although myeloid cells are crucial in tumour microenvironment, whether their specific subset can be biomarker PDAC progression unclear. Methods We analysed IL-22 receptor expression and peripheral blood. Additionally, we gene profiles IL-10R2 + /IL-22R1 presence these using single-cell RNA sequencing murine orthotropic models,...
A successful DNA vaccine for the treatment of tumors should break established immune tolerance to tumor antigen. However, due relatively low immunogenicity vaccines, compared other kinds vaccines using live virus or protein, a recombinant viral vector was used enhance humoral and cellular immunity. In current study, we sought develop novel anti-cancer agent as complex oncolytic adenovirus malignant melanoma in C57BL/6 mouse model. MART1, human melanoma-specific antigen, induce an increased...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) remains a devastating cancer due to its poor survival rate, early detection, and resectability. This study aimed determine the peripheral blood mononuclear cell (PBMC) immune biomarkers in patients with PDAC investigate PDAC-specific biomarker panel validate clinical performance. Methods In this prospective, blinded, case–control study, formula was generated using development cohort—including healthy controls, at high risk of PDAC,...
(1) Background: Pancreatic cancer is a high devastating disease with the lowest survival rate among all common cancers due to difficulties in early diagnosis. The purpose of this study was identify and characterize distinct subset blood cell population elevated peripheral mononuclear cells (PBMC) pancreatic evaluate potential markers for diagnosis cancer; (2) Methods: We analyzed differential gene expression PBMC from normal individuals patients utilizing transcriptome analysis. Flow...
Purpose: Granular corneal dystrophy type 2 (GCD2) is caused by a point mutation (R124H) in the TGF-β–induced gene (TGFBI). However, mechanisms underlying accumulation of protein (TGFBIp) are poorly understood. Therefore, we evaluated signaling cascade affecting expression TGFBIp using patient-derived cells. Methods: Keratocyte primary cultures were prepared from corneas eye bank or heterozygous homozygous patients with GCD2 after penetrating lamellar keratoplasty. diagnoses based on results...
<title>Abstract</title> Immune checkpoints such as cytotoxic T-lymphocyte associated protein 4 (CTLA-4), PD-1, and PD-L1 have been targeted for cancer therapy. However, the efficacy of this treatment approach remains limited. Beyond its expression on T-cell surface, CTLA-4 is also expressed in various cells plays roles cell proliferation, metastasis, apoptosis. Here, we reveal that targeting melanoma leads to genomic instability DNA-PKcs-STING-AKT pathway activation (via p53 p21), which turn...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor prognosis, largely due to late diagnosis and limited treatment options. The immunosuppressive tumor microenvironment (TME) further exacerbates the situation, hindering effectiveness of traditional therapies. This study investigates potential IL-10R2/IL-22R1 expressing immune cells as novel biomarkers for early PDAC detection recurrence monitoring, offering avenue improved patient outcomes. research revealed...
Abstract Background Although pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of cancer, there are no validated biomarkers for its diagnosis yet. This study aimed to investigate PDAC-specific peripheral blood biomarker panel and validate clinical performance using two cohorts. Methods prospective, blinded, case-control included A formula was created development cohort applied validation verify the diagnostic panel. The healthy controls; patients with high risk PDAC; benign...