A5011724756- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Amino Acid Enzymes and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Immune cells in cancer
- Protein Kinase Regulation and GTPase Signaling
- Cancer, Lipids, and Metabolism
- Melanoma and MAPK Pathways
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Synthesis and biological activity
- Cytokine Signaling Pathways and Interactions
- Glutathione Transferases and Polymorphisms
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Hippo pathway signaling and YAP/TAZ
- Immunotherapy and Immune Responses
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
Medical University of Vienna
2023-2024
Tyrolean Cancer Research Institute
2019-2021
Innsbruck Medical University
2018-2021
Universität Innsbruck
2018-2021
European Organisation for Research and Treatment of Cancer
2020
Max Perutz Labs
2017
University of Vienna
2017
Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa).The potential radiotherapy mediated by irradiation-induced oxidative stress and DNA damage in tumor cells.However, PCa radiocurability can be impeded resistance mechanisms normal tissue toxicity.Metabolic reprogramming major hallmarks progression therapy resistance.Specific metabolic features might serve as therapeutic targets radiosensitization biomarkers Ivyspring International Publisheridentifying...
The heavy chain of the CD98 protein (CD98hc) is encoded by SLC3A2 gene. Together with light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane amino acid transporter. High mRNA expression levels are associated poor prognosis in patients head and neck squamous cell carcinoma (HNSCC) treated radiochemotherapy. Little known regarding protein-mediated molecular mechanisms tumor radioresistance.CD98hc were correlated corresponding control dose 50 (TCD50) HNSCC xenograft models....
Cancer-associated fibroblasts (CAFs) play a key role in cancer progression and treatment outcome. This study dissects the intra-tumoral diversity of CAFs basal cell carcinoma, squamous melanoma using molecular spatial single-cell analysis. We identify three distinct CAF subtypes: myofibroblast-like RGS5+ CAFs, matrix (mCAFs), immunomodulatory (iCAFs). Large-cohort tissue analysis reveals significant shifts subtype patterns with increasing malignancy. Two subtypes exhibit properties via...
The signal to move or proliferate diverges at RAF1.
Unfavorable clinical outcomes mean that cancer researchers must attempt to develop novel therapeutic strategies overcome resistance in patients with HNSCC. Recently, ferroptosis was shown be a promising pathway possessing druggable targets, such as xCT (SLC7A11). Unfortunately, little is known about the molecular mechanisms underlying susceptibility of HNSCC cells ferroptosis. The goal this study determine whether activated Erk1/2 are vulnerable induction. Our results have (SLC7A11)...
Abstract Background Metastatic progression of breast cancer is still a challenge in clinical oncology. Therefore, an elucidation how carcinoma cells belonging to different subtypes realize their metastatic capacities needed. The aim this study was elucidate similarity activated molecular pathways underlying enhancement invasiveness subtypes. Materials and methods In order reach aim, parental invasive (INV) MDA-MB-231 (triple-negative), T47D (hormone receptor-positive), Au565 (Her2-positive)...
Statins, small molecular 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are widely used to lower cholesterol levels in lipid-metabolism disorders. Recent preclinical and clinical studies have shown that statins exert beneficial effects the management of breast cancer by increasing recurrence free survival. Unfortunately, underlying mechanisms remain elusive.Simvastatin, one most prescribed lipophilic was utilized investigate potential radiosensitizing an impact on cell survival...
Summary Cancer-associated fibroblasts (CAFs) play a key role in cancer progression and treatment outcome. This study dissects the yet unresolved intra-tumoral variety of CAFs three skin types — Basal Cell Carcinoma, Squamous Melanoma at molecular spatial single-cell resolution. By integral analysis with tumor microenvironment, including epithelial, mesenchymal, immune cells, we characterize distinct CAF subtypes: myofibroblast-like RGS5+ CAFs, matrix (mCAFs), immunomodulatory (iCAFs)....
Squamous cancers are the most frequently diagnosed solid tumours world-wide. The closely related transcriptional co-regulators YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation progression in various types squamous cell carcinoma. How execute their oncogenic functions is still not fully understood. Here, we report that addition to controlling programmes determine balance between proliferation terminal differentiation, also engages with RIF1, a key regulator DNA...
Abstract Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The potential radiotherapy mediated by irradiation-induced oxidative stress and DNA damage in tumor cells. However, PCa radiocurability can be impeded resistance mechanisms normal tissue toxicity. Metabolic reprogramming major hallmarks progression therapy resistance. Here, we found that radioresistant cells stem (CSCs) have a high glutamine demand. Glutaminase (GLS)-driven catabolism serves...
<p>Supplementary discussion; Supplementary methods; tables S1-S8; figures S1-S8.</p>
<div>AbstractPurpose:<p>The heavy chain of the CD98 protein (CD98hc) is encoded by <i>SLC3A2</i> gene. Together with light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane amino acid transporter. High mRNA expression levels are associated poor prognosis in patients head and neck squamous cell carcinoma (HNSCC) treated radiochemotherapy. Little known regarding protein–mediated molecular mechanisms tumor radioresistance.</p>Experimental...
<div>AbstractPurpose:<p>The heavy chain of the CD98 protein (CD98hc) is encoded by <i>SLC3A2</i> gene. Together with light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane amino acid transporter. High mRNA expression levels are associated poor prognosis in patients head and neck squamous cell carcinoma (HNSCC) treated radiochemotherapy. Little known regarding protein–mediated molecular mechanisms tumor radioresistance.</p>Experimental...
<p>Supplementary discussion; Supplementary methods; tables S1-S8; figures S1-S8.</p>
Introduction Despite the high efficacy of Radiation therapy (RT) to treat breast carcinoma (BC), problem radioresistance and tumour recurrence is still not solved. It believed that can be associated with presence a subpopulation cells, called ‘cancer stem cells’ (CSCs). However, it unclear which molecular profiling BC cells should used as predictor poor clinical outcome after RT. Therefore, main aim this study was determine phenotype acquired radiation resistance stemness properties....
Introduction Metastatic breast cancer (BCa) is an incurable disease with limited therapeutic response. Radiation therapy (RT) widely used in the management of metastatic BCa, however, efficacy conventional RT often not satisfying due to occurrence resistances. It suspected that BCa cells increased invasive potential exhibit intrinsic radiation resistance; there a lack models allow investigating underlying mechanisms. Therefore, aim this project establish cell lines (INV), and elucidate...