A5039276843- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Metabolomics and Mass Spectrometry Studies
- Prostate Cancer Treatment and Research
- Alcohol Consumption and Health Effects
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Hematopoietic Stem Cell Transplantation
- PI3K/AKT/mTOR signaling in cancer
German Cancer Research Center
2019-2025
Heidelberg University
2017-2025
University Hospital Carl Gustav Carus
2013-2024
OncoRay
2013-2024
TU Dresden
2013-2024
Helmholtz-Zentrum Dresden-Rossendorf
2014-2024
Deutschen Konsortium für Translationale Krebsforschung
2020-2024
University Hospital Heidelberg
2024
Heidelberger Institut für Radioonkologie
2024
National Center for Tumor Diseases
2016-2022
Radiotherapy is a curative treatment option in prostate cancer. Nevertheless, patients with high-risk cancer are prone to relapse. Identification of the predictive biomarkers and molecular mechanisms radioresistance bears promise improve therapies. In this study, we show that aldehyde dehydrogenase (ALDH) activity indicative radioresistant progenitor cells an enhanced DNA repair capacity activation epithelial-mesenchymal transition (EMT). Gene expression profiling cells, their derivatives,...
Despite recent advances in understanding of the molecular pathogenesis and improvement treatment techniques, locally advanced head neck squamous cell carcinoma (HNSCC) remains associated with an unfavorable prognosis. Compelling evidence suggests that cancer stem cells (CSC) may cause tumor recurrence if they are not eradicated by current therapies as radiotherapy or radio-chemotherapy. Recent vitro studies have demonstrated CSCs be protected from treatment-induced death multiple intrinsic...
Purpose: Radioresistance of cancer cells remains a fundamental barrier for maximum efficient radiotherapy. Tumor heterogeneity and the existence distinct cell subpopulations exhibiting different genotypes biological behaviors raise difficulties to eradicate all tumorigenic cells. Recent evidence indicates that population tumor cells, called stem (CSC), is involved in initiation recurrence putative cause radioresistance. There an urgent need identify intrinsic molecular mechanisms regulating...
Radiotherapy is a mainstay of curative prostate cancer treatment, but risks recurrence after treatment remain significant in locally advanced disease. Given that tumor relapse can be attributed to population stem cells (CSC) survives radiotherapy, analysis this cell might illuminate tactics personalize treatment. However, direction remains challenging given the plastic nature cancers following We show here irradiating stimulates durable upregulation markers epigenetically reprogram these...
The heavy chain of the CD98 protein (CD98hc) is encoded by SLC3A2 gene. Together with light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane amino acid transporter. High mRNA expression levels are associated poor prognosis in patients head and neck squamous cell carcinoma (HNSCC) treated radiochemotherapy. Little known regarding protein-mediated molecular mechanisms tumor radioresistance.CD98hc were correlated corresponding control dose 50 (TCD50) HNSCC xenograft models....
Abstract Glioneuronal tumors are a heterogenous group of CNS neoplasms that can be challenging to accurately diagnose. Molecular methods highly useful in classifying these tumors—distinguishing precise classes from their histological mimics and identifying previously unrecognized types tumors. Using an unsupervised visualization approach DNA methylation data, we identified novel ( n = 20) formed cluster separate all established tumor types. analyses revealed ATRX alterations (in 16/16 cases...
Abstract Background: Hypoxia contributes to tumor therapy resistance and it can be evaluated through imaging, such as [18F]fluoromisonidazole (FMISO)-PET, or hypoxia-associated gene expression profiling, among other modalities. Integrating imaging with microenvironment features may provide a more comprehensive prognostic assessment. This study evaluates the value of combining FMISO-PET hypoxia baseline profiles in head neck squamous cell carcinoma (HNSCC) patients undergoing...
Abstract Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an advanced stage, conferring a poor prognosis. The probability of local tumor control after radiotherapy depends on the eradication cancer stem cells (CSCs) with activated DNA repair. This study provides evidence that CSC-related transcription factor Oct4 contributes to HNSCC radioresistance by regulating damage response CSC phenotype. Knockdown A isoform reduced self-renewal capacity in led partial...
Background Although the mitogen-activated protein kinases (MAPK) pathway is hyperactive in head and neck cancer (HNC), inhibition of MEK1/2 HNC patients has not shown clinically meaningful activity. Therefore, we aimed to characterize effect on tumor microenvironment (TME) MAPK-driven HNC, elucidate tumor-host interaction mechanisms facilitating immune escape treatment, apply rationale-based therapy combination immunotherapy inhibitor induce clearance. Methods Mouse syngeneic tumors...
Ablative radiotherapy is a highly efficient treatment modality for patients with metastatic prostate cancer (PCa). However, subset of does not respond. Currently, this subgroup bad prognosis cannot be identified before disease progression. We hypothesize that markers indicative radioresistance, stemness and/or bone tropism may have prognostic potential to identify profiting from metastases-directed radiotherapy. Therefore, circulating tumor cells (CTCs) were analyzed in PCa (n = 24) during...
Head and neck squamous cell carcinoma (HNSCC) exhibits considerable variability in patient outcome. It has been reported that SOX2 plays a role proliferation, tumor growth, drug resistance, metastasis variety of cancer types. Additionally, SOX9 implicated immune tolerance treatment failures. induce failure by molecular mechanism not yet elucidated. This study explores the inverse association SOX2/SOX9 their distinct expression tumors, influencing microenvironment radiotherapy responses....
The chemical composition, especially of aerosol particles, in the extratropical upper troposphere and lower stratosphere (exUTLS) plays a crucial role radiation budget atmosphere. This composition is affected by large-scale dynamics troposphere, additionally small-scale processes. effects particle number concentration as well lowermost (exLMS) are major research topic recent years. measurements presented this study were taken during TPEx campaign (Tropopause gradients mixing Experiment)...
Journal Article Hematopoietic stem and progenitor cells in adhesive microcavities Get access Ina Kurth, Kurth Leibniz Institute of Polymer Research, Max Bergmann Center Biomaterials, 01069, Dresden, Germany Search for other works by this author on: Oxford Academic Google Scholar Katja Franke, Franke Tilo Pompe, Pompe E-mail: pompe-tilo@ipfdd.de Martin Bornhäuser, Bornhäuser Universita¨tsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik I, 01307, GermanyCenter Regenerative...
Blocking the mitogen-activated protein kinase (MAPK) pathway with MEK1/2 inhibitor trametinib has produced promising results in patients head and neck squamous cell carcinoma (HNSCC). In current study, we showed that treatment leads to overexpression activation of epidermal growth factor receptor (EGFR) HNSCC lines patient-derived xenografts. Knockdown EGFR improved efficacy both vitro vivo. Mechanistically, demonstrated trametinib-induced hyperactivates phosphatidylinositol 3-kinase...
Abstract Polymeric microcavities functionalized with extracellular matrix components were used as an experimental in vitro model to investigate principles of hematopoietic stem and progenitor cell (HSPC) fate control. Using human CD133+ HSPC we could demonstrate distinct differences cycling differentiation dependence on the adhesion ligand specificity (i.e., heparin, collagen I) cytokine levels. The presented microcavity platform provides a powerful approach explore role exogenous cues...
(1) Background: The sensitivity of head and neck squamous cell carcinoma (HNSCC) to ionizing radiation, among others, is determined by the number cells with high clonogenic potential stem-like features. These cellular characteristics are dynamically regulated in response treatment may lead an enrichment radioresistant a cancer stem (CSC) phenotype. Epigenetic mechanisms, particularly DNA histone methylation, key regulators gene-specific transcription plasticity. Therefore, we hypothesized...
Many tumors including prostate cancer are maintained by stem cells (CSCs), which might cause tumor relapse if not eradicated during the course of treatment. Specific targeting or radiosensitization CSCs bear promise to improve curability synergistic effects in combination with radiotherapy. Carbon nanotubes (CNTs) can be used as promising drug delivery systems for anticancer drugs such flavonoid catechin. Catechin is an extensively studied active ingredient different plants, green tea, and...