A5091805512- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- MicroRNA in disease regulation
- Bone and Joint Diseases
- Mesenchymal stem cell research
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- T-cell and B-cell Immunology
- Multiple Myeloma Research and Treatments
- Transplantation: Methods and Outcomes
- Neutropenia and Cancer Infections
- RNA Interference and Gene Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Chronic Lymphocytic Leukemia Research
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- Neurogenetic and Muscular Disorders Research
- Protein Degradation and Inhibitors
- Liver physiology and pathology
People's Liberation Army Air Force
2014-2016
Air Force General Hospital PLA
2006-2016
Dalian Medical University
2015
Anhui Medical University
2014
Chinese PLA General Hospital
2008
Sun Yat-sen University
2000-2003
Zhujiang Hospital
2000-2002
In this report, the authors describe a protocol for haploidentical bone marrow transplantation in children who received G-CSF-mobilized grafts without T-cell depletion from HLA-mismatched parents. Forty-two of 45 patients achieved complete donor hematopoietic engraftment; medium time neutrophil and platelet recovery was 17 19 days, respectively. Three died early transplantation-associated complications; other causes death included relapse (11 cases), fungal pneumonia (5), acute...
Histone H2AX is a tumor suppressor protein that plays an important role in apoptosis. However, the mechanism underlying association of with apoptosis cancer cells remains elusive. Here, we showed knockdown lung A549 affected expression 16 microRNAs (miRNAs), resulting downregulation 1 and upregulation 15 miRNAs. MicroRNA-3196 (miR-3196) was identified as target shown to inhibit by targeting p53 upregulated modulator (PUMA). Phosphorylated (γH2AX) bind promoter miR-3196 regulate its...
Micro (mi)RNAs are short non‑coding RNA molecules, which post‑transcriptionally regulate gene expression and exert key roles in cell growth, differentiation apoptosis. In the present study, mechanism function of miR‑1915‑3p apoptotic regulation lung cancer lines (NCI‑H441 NCI‑H1650) were investigated. The analysis confirmed that was markedly decreased cells. overexpression cells prevented apoptosis induced by etoposide. Developmentally regulated GTP‑binding protein 2 (DRG2) pre‑B leukemia...
Although both oxidative stress and microRNAs (miRNAs) play vital roles in physiological pathological processes, little is known about the interactions between them. In this study, we first described regulation of H2O2 cell viability, proliferation, cycle, apoptosis human hepatocellular carcinoma line HepG2. Then, miRNAs expression was profiled after treatment. The results showed that high concentration (600 μM) could decrease inhibit induce cycle arrest, finally promote apoptosis....
Here, we report the preliminary results of haploidentical hematopoietic stem cell transplantation (Haplo-HSCT) with granulocyte-colony-stimulating factor (G-CSF) mobilized bone marrow grafts without T-cell depletion for 10 patients refractory non-Hodgkin lymphoma accompanied by involvement. Eight received a conditioning regimen consisting high-doses cytarabine and cyclophosphamide total body irradiation, whereas two cases were preconditioned busulfan, thiotepa, cyclophosphamide. All had...
Abstract Graft‐vs.‐host disease (GVHD) remains the major limitation of allogeneic bone marrow transplantation (BMT) and stem cell transplantation, leukemia recurrence is another important complication in treatment. Immature CD8 α + dendritic cells (DC) have good potential GVHD treatment immunological tolerance studies. To find a new way to prevent GVHD, not increasing risk recurrence, this study, predominant immature DC were induced from murine (BM) by 5 ng/mL granulocyte‐macrophage colony...
To explore the safety and efficiency of unrelated donor peripheral blood stem cells (URD-PBSC) transplantation combined with umbilical cord mesenchymal (UC-MSC).The clinical data 49 patients received (URD-PBSCT) for treating hematologic malignancies were retrospectively evaluated, including 12 ANLL, 17 ALL, 18 CML 2 MDS. Out them, 22 URD-PBSCT UC-MSC 27 only URD-PBSCT. The average number infusing was 1.0 × 10⁶/kg in UC-MSC+URD-PBSCT group.As compared group, group median recovery time...