A5009880877- Influenza Virus Research Studies
- Respiratory viral infections research
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Vaccine Coverage and Hesitancy
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Immunotherapy and Immune Responses
- Hemoglobin structure and function
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Hematological disorders and diagnostics
- interferon and immune responses
- Childhood Cancer Survivors' Quality of Life
- Immune Response and Inflammation
- Animal health and immunology
- Herbal Medicine Research Studies
- Infant Development and Preterm Care
- Dermatology and Skin Diseases
- Diversity and Career in Medicine
- Reproductive System and Pregnancy
- Exercise and Physiological Responses
College of Saint Benedict and Saint John's University
2019-2024
Johns Hopkins University
2015-2022
Emory University
2018
University of North Dakota
2017
Martin Luther University Halle-Wittenberg
2016
Significance Biological sex is typically not considered in the evaluation of vaccine responses and protection against infection. We show that female mice mount greater humoral cell-mediated immune to influenza infection vaccination than males. Females can rely solely on antibody for following vaccination, which associated with expression toll-like receptor 7 ( Tlr7 ) caused by epigenetic mechanisms B cells from females. Deletion reduces differences vaccine-induced protection. The increased...
Abstract Vaccine-induced immunity declines with age, which may differ between males and females. Using human sera collected before 21 days after receipt of the monovalent A/Cal/09 H1N1 vaccine, we evaluated cytokine antibody responses in adult (18–45 years) aged (65+ individuals. After vaccination, females developed greater IL-6 than either or females, female being positively associated concentrations estradiol. To test whether protection against influenza virus challenge was males, primed...
In addition to their intended use, progesterone (P4)-based contraceptives promote anti-inflammatory immune responses, yet effects on the outcome of infectious diseases, including influenza A virus (IAV) infection, are rarely evaluated. To evaluate impact responses sequential IAV infections, adult female mice were treated with placebo or one two progestins, P4 levonorgestrel (LNG), and infected a mouse-adapted H1N1 (maH1N1) virus. Treatment LNG reduced morbidity but had no effect pulmonary...
Inactivated influenza vaccines induce greater antibody responses in females than males among both humans and mice. To test the breadth of protection, we used recombinant mouse-adapted A/California/2009 (maA/Cal/09) H1N1 viruses containing mutations at one (1M), two (2M), or three (3M) antigenic sites, addition to a virus 1M mutation substitution Ca2 site (Sub) with derived from an H5 hemagglutinin (HA) challenge mice sexes. Following maA/Cal/09 vaccination, produced virus-specific,...
Amphiregulin (AREG) is an epidermal growth factor that a significant mediator of tissue repair at mucosal sites, including in the lungs during influenza A virus (IAV) infection. Previous research illustrates males reproductive ages experience less severe disease and recover faster than females following infection with IAV. Whether differentially produce utilize AREG for pulmonary after IAV was investigated using murine models on C57BL/6 background primary mouse human epithelial cell culture...
Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are severe disease manifestations that can occur following sequential infection with different virus serotypes (DENV1-4). At present, there no licensed therapies to treat DENV-induced disease. DHF DSS thought be mediated by serotype cross-reactive antibodies facilitate antibody-dependent enhancement (ADE) binding viral antigens then Fcγ receptors (FcγR) on target myeloid cells. Using genetically engineered DENV-specific...
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify that may pose a human public health risk. Since 1999, canine H3 viruses (CIVs) have caused many thousands or millions respiratory infections in dogs United States. While no with CIVs been reported date, these could zoonotic In studies, National Institutes Allergy Infectious Diseases (NIAID) Centers Excellence Influenza Research Surveillance...
Abstract Dengue virus (DENV) is the most prevalent arbovirus with worldwide cases increasing from 2.2 to 3.2 million in last 5 years. Symptoms of DENV infection range a mild fever extensive vasculature permeability resulting hemorrhagic and shock. Passive active vaccines have been unsuccessful protecting or treatment for because antibody dependent enhancement (ADE), increased viral load due monocyte opsonization by non-neutralizing Abs different serotype. We previously demonstrated that...
Physical activity is known to modulate immune cell function and understanding its role in vaccine-induced immunity critical for both optimizing vaccine strategies implementing lifestyle factors that contribute better health. This study aimed elucidate the impact of physical on antibody responses following influenza vaccination, with a specific focus biological sex differences among male female cross-country athletes. Based previous studies, we hypothesized would increase responses,...
Seasonal epidemics of influenza are characterized through national or international surveillance efforts to determine vaccine efficacy and strain selection, but they do not provide detailed information about local variations in factors that can influence cases disease severity. Surveillance for like illness was performed Emergency Medicine Departments Taipei, Taiwan Baltimore, Maryland during the winter 2015–16. Detailed demographic clinical data were obtained. Nasal swabs washes collected...
Background Seasonal epidemics of influenza are often characterized through national or international surveillance efforts to determine vaccine efficacy and strain selection, but they do not provide detailed information about local variations in factors that can influence cases disease severity. Methods Surveillance for like illness was performed Emergency Medicine Departments Taipei, Taiwan Baltimore, Maryland during the winter 2015-16. Detailed demographic clinical data were obtained. Nasal...
Background/Purpose: After publication of the ICF-CY (WHO 2007) there has been an international discussion about participation children, its definition, delineation and operationalization in outcome measures recent years. The is a multidimensional classification system disease that - enlargement standard diagnostic tool ICD- describes activity opportunities patients compliance with contextual factors. Participation defined as "involvement life situation" follows superordinate goal action,...
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify that may pose a human public health risk. Since 1999, canine H3 viruses (CIVs) have caused many thousands or millions respiratory infections in dogs United States. While no with CIVs been reported date, these could zoonotic In studies, National Institutes Allergy Infectious Diseases (NIAID) Centers Excellence Influenza Research Surveillance...