A5065815927- Influenza Virus Research Studies
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Herpesvirus Infections and Treatments
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- COVID-19 diagnosis using AI
- COVID-19 Impact on Reproduction
- Sex and Gender in Healthcare
- Immunotherapy and Immune Responses
Johns Hopkins University
2021-2023
University of Colorado Boulder
2019-2021
Inactivated influenza vaccines induce greater antibody responses in females than males among both humans and mice. To test the breadth of protection, we used recombinant mouse-adapted A/California/2009 (maA/Cal/09) H1N1 viruses containing mutations at one (1M), two (2M), or three (3M) antigenic sites, addition to a virus 1M mutation substitution Ca2 site (Sub) with derived from an H5 hemagglutinin (HA) challenge mice sexes. Following maA/Cal/09 vaccination, produced virus-specific,...
Abstract In the ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2), more outcomes are reported in males compared with females, including hospitalizations and deaths. Animal models can provide an opportunity to mechanistically interrogate causes of sex differences pathogenesis SARS-CoV-2. Adult male female golden Syrian hamsters (8-10 weeks age) were inoculated intranasally 10 5 TCID 50 SARS-CoV-2/USA-WA1/2020 euthanized at several...
Gammaherpesviruses are a prime example of how viruses can alter the host transcriptional landscape to establish infection. Despite major insights into these modify RNA polymerase II-dependent generation messenger RNAs, influence activity III remains much less clear.
ABSTRACT RNA polymerase III (pol III) transcribes multiple non-coding (nc) RNAs that are essential for cellular function. Pol III-dependent transcription is also engaged during certain viral infections, including the gammaherpesviruses (γHVs), where pol ncRNAs promote pathogenesis. Additionally, several host upregulated γHV infection and play integral roles in pathogenesis by facilitating establishment gene expression. Here, we sought to investigate how promoters transcripts regulated...
Abstract Inactivated influenza vaccines induce greater antibody responses in females than males among both humans and mice. To test the breadth of protection, we used recombinant mouse-adapted A/California/2009 (maA/Cal/09) H1N1 viruses containing mutations at one (1M), two (2M), or three (3M) antigenic sites, addition to a virus 1M mutation substitution Ca2 site (Sub) with derived from an H5 hemagglutinin (HA) challenge mice sexes. Following maA/Cal/09 vaccination, produced virus-specific...