A5017811864- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Toxoplasma gondii Research Studies
- Respiratory viral infections research
- Coccidia and coccidiosis research
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Long-Term Effects of COVID-19
- Facial Trauma and Fracture Management
- COVID-19 epidemiological studies
- Microbial infections and disease research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Ophthalmology and Visual Health Research
- Vasculitis and related conditions
- Retinal Diseases and Treatments
- COVID-19 diagnosis using AI
- Rabies epidemiology and control
- Helminth infection and control
- Bone Tumor Diagnosis and Treatments
- Meningioma and schwannoma management
- dental development and anomalies
Instituto da Visão
2020-2024
Universidade Federal de São Paulo
2019-2024
Instituto Paulista de Ensino e Pesquisa
2020-2024
Johns Hopkins University
2021-2023
Instituto Paulista de Estudos e Pesquisas em Oftalmologia
2023
Hospital São Paulo
2020
Universidade do Estado do Amazonas
2014
Hospital Nossa Senhora da Conceição
2007
Universidade Iguaçu
2007
Univar (United Kingdom)
2007
Men experience more severe outcomes from coronavirus disease 2019 (COVID-19) than women. Golden Syrian hamsters were used to explore sex differences in the pathogenesis of a human clinical isolate acute respiratory syndrome 2 (SARS-CoV-2).
The presence of the SARS-CoV-2 virus in retina deceased patients with COVID-19 has been suggested through real-time reverse polymerase chain reaction and immunological methods to detect its main proteins. eye shown abnormalities associated infection, retinal changes were presumed be secondary microvascular changes.To demonstrate viral particles relevant proteins eyes COVID-19.The from enucleated confirmed infection submitted immunofluorescence transmission electron microscopy processing at a...
The primary purpose of this study was to assess vascular retinal findings temporally related COVID-19 vaccination. With greater information regarding all possible future adverse events, we hope understand the real dimension and relevance what presented.Eleven patients with visual complaints after vaccination were enrolled. Data on following included: age, sex, vaccine, time symptom onset, systemic findings, medical history, best-corrected acuity, ocular by slit-lamp biomicroscopy as well...
To evaluate the concentration of tear lysozyme in individuals with Sjogren´s syndrome, meibomian gland dysfunction, and non-dry-eye disease.Ninety subjects were recruited for this study, including 30 disease. All referred to participate study based on a "dry eye" investigation. They underwent complete ocular surface ophthalmic examination encompassing disease index, biomicroscopy, break-up time, Schirmer test type I, conjunctival vital staining fluorescein lissamine green, concentration,...
With increasing incidence of yellow fever, mass campaign vaccinations are underway and little ophthalmological alterations have been reported in literature, specially regarding non-combined vaccines.
Abstract Background Ocular toxoplasmosis is one of the most common causes intraocular inflammation and posterior uveitis in immunocompetent patients. This paper aims to investigate swept-source optical coherence tomography angiography (SS-OCTA) findings eyes with active toxoplasmic retinochoroiditis. Methods case series was conducted from November 2017 through October 2019 two Brazilian centers. 15 patients retinochoroiditis were included, imaged at baseline after least 4 weeks follow-up....
The main purpose of this study was to investigate ocular clinical findings in patients with confirmed COVID-19 infection, various levels disease severity, who required mechanical ventilation and admission intensive care units or specialized wards. Longitudinal, observational conducted from March 2020 June 2020. Color fundus red-free photography were performed both eyes following pupillary dilation. 104 participants recruited 2 different centers: 60 (58%) the Hospital Municipal de Barueri...
PURPOSE: To describe a 2019 acute toxoplasmosis outbreak in the city of São Paulo, Brazil, and to evaluate laboratory serological profile for three consecutive years. The ophthalmological manifestations patients involved were also studied. METHODS: A cross-sectional descriptive study between February May 2019. Epidemiological data described, as observed ocular manifestations. As part this number with positive IgM serology was obtained from large network (DASA) years, including year (2018,...
Abstract In the ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2), more outcomes are reported in males compared with females, including hospitalizations and deaths. Animal models can provide an opportunity to mechanistically interrogate causes of sex differences pathogenesis SARS-CoV-2. Adult male female golden Syrian hamsters (8-10 weeks age) were inoculated intranasally 10 5 TCID 50 SARS-CoV-2/USA-WA1/2020 euthanized at several...
Abstract Surveillance for emerging human influenza virus clades is important identifying changes in viral fitness and assessing antigenic similarity to vaccine strains. While structure are both aspects of success, they distinct characteristics do not always change a complementary manner. The 2019–2020 Northern Hemisphere season saw the emergence two H1N1 clades: A5a.1 A5a.2. several studies indicated that A5a.2 showed similar or even increased drift compared with A5a.1, clade was still...
Purpose To describe the effect of long-term, low-dose pyrimethamine for prevention ocular toxoplasmosis (OT) recurrences.
The results of the SERPICO-19 study [[1]Invernizzi A. Torre Parrulli S. Zicarelli F. Schiuma M. et al.Retinal Findings in patients with COVID-19: from study.EClinicalMedicine. 2020; https://doi.org/10.1016/j.eclinm.2020.100550Summary Full Text PDF PubMed Scopus (160) Google Scholar] published EClinicalMedicine suggest that regardless comorbidities or treatments, exposed to Sars-CoV-2 virus should have fundus evaluation, even though no visual complaints are described. In study, 54 COVID-19...
O Diabetes Mellitus Gestacional (DMG) é uma condição ligada ao crescimento da resistência à insulina durante a gestação mulher. A sua incidência tem crescido consideravelmente longo dos anos. Esta doença monitorada o pré-natal por meio de testes glicemia em certos momentos gravidez. Este rastreamento feito tanto no começo do pré-natal, através medição jejum, que deve ser inferior 92mg/dL, quanto entre as 24 e 28 semanas, período se recomenda realização Teste Oral Tolerância Glicose (TOTG)...
ABSTRACTPurpose COVID-19 (coronavirus disease 2019) is an infectious caused by SARS-CoV-2, first reported in 2019 Wuhan, China. Among the common complications a pro-inflammatory and hypercoagulative response that compromises vasculature among various organs.Methods In this report, we present postmortem retinal findings of five patients observed means optical microscopy transmission scanning electron techniques.Results Clinical manifestations such as hemorrhages exacerbated inflammatory...
The main purpose of this study was to investigate the presence retinal autofluorescence findings in COVID-19 patients. Observational conducted São Paulo 2020. Demographic, medical history, and concomitant events, as well medications used, hospitalization details, laboratory test results, were obtained. Patients underwent eye examination multimodal imaging, including color, red-free, fundus photography optical coherence tomography. Eighteen patients had (6 females; average age 54 years, range...
Abstract To catalyze SARS-CoV-2 research including development of novel interventive and preventive strategies, we characterized progression disease in depth a robust COVID-19 animal model. In this model, male female golden Syrian hamsters were inoculated intranasally with USA-WA1/2020. Groups mock-inoculated uninfected control animals euthanized at day 2, 4, 7, 14, 28 days post-inoculation to track multiple clinical, pathology, virology, immunology outcomes. SARS-CoV-2-inoculated...
Surveillance for emerging human influenza virus clades is important identifying changes in viral fitness and assessing antigenic similarity to vaccine strains. While structure are both aspects of success, they distinct characteristics do not always change a complementary manner. The 2019-20 Northern Hemisphere season saw the emergence two H1N1 clades: A5a.1 A5a.2. several studies indicated that A5a.2 showed similar or even increased drift compared with A5a.1, clade was still predominant...