A5100422134- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Sepsis Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Hybrid Renewable Energy Systems
- Lung Cancer Treatments and Mutations
- Emergency and Acute Care Studies
- Power Systems and Renewable Energy
- Tracheal and airway disorders
- Carcinogens and Genotoxicity Assessment
- Renal function and acid-base balance
- Occupational exposure and asthma
- Cancer Cells and Metastasis
- IL-33, ST2, and ILC Pathways
- Acute Kidney Injury Research
- Phytochemistry and Biological Activities
- Magnesium in Health and Disease
- Phytochemicals and Antioxidant Activities
- Maritime Transport Emissions and Efficiency
- Cancer Genomics and Diagnostics
- Per- and polyfluoroalkyl substances research
- PI3K/AKT/mTOR signaling in cancer
- Peptidase Inhibition and Analysis
Wuxi No.2 People's Hospital
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2024
Chongqing Medical University
2015-2024
Tianjin Medical University General Hospital
2024
Abstract Background Early identification of noninvasive ventilation (NIV) failure is a promising strategy for reducing mortality in chronic obstructive pulmonary disease (COPD) patients. However, risk-scoring system lacking. Methods To develop scale to predict NIV failure, 500 COPD patients were enrolled derivation cohort. Heart rate, acidosis (assessed by pH), consciousness Glasgow coma score), oxygenation, and respiratory rate (HACOR) entered into the scoring system. Another two groups 323...
Abstract Background Heart rate, acidosis, consciousness, oxygenation, and respiratory rate (HACOR) have been used to predict noninvasive ventilation (NIV) failure. However, the HACOR score fails consider baseline data. Here, we aimed update take into account data test its predictive power for NIV failure primarily after 1–2 h of NIV. Methods A multicenter prospective observational study was performed in 18 hospitals China Turkey. Patients who received because hypoxemic were enrolled. In...
Eriodictyol is an important flavonoid and commonly present across the plant kingdom. Flavonoids have been reported to show incredible pharmacological potential. However, anticancer activity of eriodictyol has not well reported. In study we determined its potential against human lung cancer cell line A549.The initial cytotoxicity induced by was measured MTT assay. Flow cytometry used effects on apoptosis, cycle phase distribution mitochondrial membrane loss. The comet assay measure DNA damage...
Serum phosphate levels have been reported to be linked the prognosis in critically ill patients. The purpose of this study was analyze impact trajectory changes serum on short-term mortality risk patients with sepsis. This retrospective cohort used data sepsis from 2008–2019 Medical Information Mart for Intensive Care IV (MIMIC-IV) database. level trajectories were constructed using a latent growth mixture modeling (LGMM) based four measurements at six-hour intervals within 24 h admission...
Abstract Background Factors that may increase the risk for delirium and firm knowledge around mechanism in noninvasive ventilation (NIV) patients is lacking. We investigated incidence, characteristics, outcomes of NIV patients. Methods A prospective observational study was performed an intensive care unit (ICU) a teaching hospital. Patients whom used as first-line intervention were enrolled. During intervention, screened using Confusion Assessment Method ICU each day. The association between...
Sepsis and septic shock are common in noninvasive ventilation (NIV) patients. However, studies on the association between sepsis NIV failure lacking.A prospective multi-center observational study was performed 16 Chinese intensive care units (ICUs). Patients who used due to hypoxemic respiratory were enrolled. diagnosed according guideline of sepsis-3.A total 519 patients developed 365 (70%) 79 (15%). 75 (14%) had no sepsis. 23%, 38%, 61% patients, with sepsis, shock, respectively....
Abstract Background Cough strength is associated with short-term outcome in patients scheduled extubation who successfully complete a spontaneous breathing trial (SBT). However, the long-term unclear. Methods This was prospective observational study performed respiratory ICU of teaching hospital. COPD completed SBT were candidates. We enrolled case assessed cough by peak flow (CPF) or semiquantitative score (SCSS, ranging from 0 = weak to 5 strong). Patients followed up two years phone every...
Abstract The environmental factor aryl hydrocarbon receptor (AhR), a key protein connecting the external signals (e.g., endocrine disruptor TCDD) to internal cellular processes, is involved in activation of peripheral macrophages and inflammatory response human body. Thus, there widespread interest finding compounds anti‐inflammatory by targeting AhR. Here, ensemble docking based‐virtual screening was first used screen library (~200,000 compounds) against AhR ligand binding domain (LBD) 25...
Propofol and midazolam are commonly used sedative drugs in mechanically ventilated patients the Intensive Care Unit (ICU). However, there is still a lack of relevant studies exploring influence propofol on prognosis with Sepsis-associated Acute Kidney Injury (S-AKI).
Abstract Background : Knowledge of delirium in noninvasive ventilation (NIV) is lacking. We aimed to report the incidence, characteristics and outcomes NIV patients. Methods A prospective observational study was performed an intensive care unit (ICU) a teaching hospital. Patients who used as fist-line intervention were enrolled. During intervention, screened using Confusion Assessment Method for ICU every day. Results enrolled 1083 Of them, 196 patients (18.1%) experienced during...
Abstract Background : Factors that may increase the risk for delirium and firm knowledge around mechanism in noninvasive ventilation (NIV) patients is lacking. We investigated incidence, characteristics, outcomes of NIV patients. Methods A prospective observational study was performed an intensive care unit (ICU) a teaching hospital. Patients whom used as first-line intervention were enrolled. During intervention, screened using Confusion Assessment Method ICU each day. The association...
Abstract Background : Knowledge of delirium in noninvasive ventilation (NIV) patients is lacking. We investigated the incidence, characteristics, and outcomes NIV patients. Methods A prospective observational study was performed an intensive care unit (ICU) a teaching hospital. Patients whom used as first-line intervention were enrolled. During intervention, screened using Confusion Assessment Method for ICU each day. The association between poor (e.g., failure, hospital mortality) forward...
Abstract Background: The failure rate of noninvasive ventilation (NIV) remains high in patients with acute respiratory distress syndrome (ARDS). etiology ARDS may play an important role NIV failure. Methods: A multicenter prospective observational study was performed 17 ICUs China from September 2017 to December 2019. who used as a first-line therapy were enrolled. recorded at entry. Results: total 306 Of the patients, 146 classified having pulmonary (ARDSp) and 160 extrapulmonary (ARDSexp)....