A5074040550- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Anesthesia and Sedative Agents
- Nosocomial Infections in ICU
- Aquaculture disease management and microbiota
- Cardiac Arrest and Resuscitation
- Emergency and Acute Care Studies
- Turtle Biology and Conservation
- Vibrio bacteria research studies
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Tuberculosis Research and Epidemiology
- Neonatal Respiratory Health Research
- Antimicrobial Peptides and Activities
- Ocular Infections and Treatments
- HIV/AIDS drug development and treatment
- Bee Products Chemical Analysis
- Acute Kidney Injury Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Mechanisms and Therapy
- Parasite Biology and Host Interactions
- HIV/AIDS oral health manifestations
- Pneumothorax, Barotrauma, Emphysema
The Affiliated Yongchuan Hospital of Chongqing Medical University
2011-2024
Chongqing Medical University
2011-2024
University of Pittsburgh Medical Center
2024
Urumqi General Hospital of PLA
2023
Chongqing University
2021
Chongqing Dazu District People's Hospital
2020
First Affiliated Hospital of Fujian Medical University
2011-2018
Fujian Medical University
2011-2018
The clinical characteristics of the patients with COVID-19 complicated by pneumothorax have not been clarified.To determine epidemiology and risks in critically ill COVID-19.Retrospectively collecting analysing medical records, laboratory findings, chest X-ray CT images 5 pneumothorax.The incidence was 10% (5/49) ARDS, 24% (5/21) receiving mechanical ventilation, 56% (5/9) requiring invasive 80% (4/5) died. All were male aged ranging from 54 to 79 years old. Pneumothorax most likely occur 2...
Abstract Background Early identification of noninvasive ventilation (NIV) failure is a promising strategy for reducing mortality in chronic obstructive pulmonary disease (COPD) patients. However, risk-scoring system lacking. Methods To develop scale to predict NIV failure, 500 COPD patients were enrolled derivation cohort. Heart rate, acidosis (assessed by pH), consciousness Glasgow coma score), oxygenation, and respiratory rate (HACOR) entered into the scoring system. Another two groups 323...
Mortality is high among severe patients with 2019 novel coronavirus-infected disease (COVID-19). Early prediction of progression to cases needed. We retrospectively collected COVID-19 in two hospital Chongqing from 1st January 29th February 2020. At admission, we the demographics and laboratory tests predict whether patient would progress hospitalization. Severe case was confirmed when one following criteria occurred: (a) dyspnea, respiratory rate ≥30 breaths/min, (b) blood oxygen saturation...
Abstract Background Heart rate, acidosis, consciousness, oxygenation, and respiratory rate (HACOR) have been used to predict noninvasive ventilation (NIV) failure. However, the HACOR score fails consider baseline data. Here, we aimed update take into account data test its predictive power for NIV failure primarily after 1–2 h of NIV. Methods A multicenter prospective observational study was performed in 18 hospitals China Turkey. Patients who received because hypoxemic were enrolled. In...
Reintubation is associated with high mortality. Identification of methods to avoid reintubation needed. The aim this study was assess whether prophylactic noninvasive ventilation (NIV) would benefit patients various cough strengths.We prospectively enrolled 356 who successfully passed a spontaneous breathing trial in respiratory intensive care unit. Before extubation, peak flow measured. After attending physicians determined the receive NIV or conventional oxygen treatment (control group)....
Abstract Background Factors that may increase the risk for delirium and firm knowledge around mechanism in noninvasive ventilation (NIV) patients is lacking. We investigated incidence, characteristics, outcomes of NIV patients. Methods A prospective observational study was performed an intensive care unit (ICU) a teaching hospital. Patients whom used as first-line intervention were enrolled. During intervention, screened using Confusion Assessment Method ICU each day. The association between...
Sepsis and septic shock are common in noninvasive ventilation (NIV) patients. However, studies on the association between sepsis NIV failure lacking.A prospective multi-center observational study was performed 16 Chinese intensive care units (ICUs). Patients who used due to hypoxemic respiratory were enrolled. diagnosed according guideline of sepsis-3.A total 519 patients developed 365 (70%) 79 (15%). 75 (14%) had no sepsis. 23%, 38%, 61% patients, with sepsis, shock, respectively....
A rating scale that takes into account heart rate, acidosis, consciousness, oxygenation, and respiratory rate (the HACOR score) has been used to predict noninvasive ventilation (NIV) failure in patients with chronic obstructive pulmonary disease (COPD). However, the score not NIV non-COPD acute-on-chronic failure.This study was performed intensive care unit of a teaching hospital. Data had collected prospectively between June 2011 January 2019. We enrolled who received due failure, pH <...
Pneumocystis pneumonia (PCP) occurs predominately in patients with impaired immunity. Because standard PCP chemoprophylaxis and chemotherapies have limitations, immunotherapy, particularly vaccination, offers an attractive alternative approach for prevention treatment. The goal of this study was to evaluate the potential DNA vaccines targeting two closely related antigens, p55-v0 p55-v3, immunosuppressed rat model. We found that immunization p55-v3 afforded a similar level protection rats...
Purpose: To investigate the biochemical characteristics in experimental keratomycosis by Raman spectroscopy analysis vitro and vivo.Methods: was used to analyze of cultured mouse keratocytes stimulated Fusarium solani suspension vitro, infected cornea keratitis mice.Results: The peak intensities at 1005, 1186, 1311, 1449 1657 cm–1, which represented phenylalanine, tyrosine, nucleic acid bases, phospholipids α-helix, were decreased compared with control keratocytes. consistency spectra...
Purpose: To explore the inhibitory activity of Lactobacillus salivarius ssp. JCM1231 (L. JCM1231) culture filtrate against Fusarium solani (F. solani) and its effects on murine keratocytes (MKs) infected with F. solani.Methods: L. was cultured in an anaerobic incubator for 24 h, (LSCF) prepared .The antifungal determined a plate overlay assay, agar diffusion conidial germination inhibition test. The temperature, pH, proteolytic enzymes LSCF were detected microtiter plate-well assay assay....
Background. Risk factors for noninvasive ventilation (NIV) failure after initial success are not fully clear in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods. Patients who received NIV beyond 48 h due to COPD were enrolled. However, we excluded those whose pH was higher than 7.35 or PaCO2 less 45 mmHg which measured before NIV. Late defined as required intubation died during success. Results. We enrolled 291 this study. Of them, (16%) experienced...
The aim of the present study was to investigate effects bone marrow‑derived mesenchymal stem cells (BMSCs) transfected with survivin on lung fibrosis in mice. Mice bleomycin‑induced pulmonary were allocated at random group A, B or C, and injected 1x106 gene‑expressing BMSCs, BMSCs normal saline, respectively. A total 6 mice sacrificed from each days 7, 14 28 after treatment. extent alveolitis assessed apoptotic rates survivin‑expressing detected. content surfactant protein (SP‑A)...
Objective To report the resource use, characteristics and outcomes of patients with prolonged non-invasive ventilation (NIV). Design A single-centre observational study. Setting An intensive care unit a teaching hospital. Participants Patients who only received NIV because acute respiratory failure were enrolled. Prolonged was defined as subjects ≥14 days. total 1539 enrolled in this study; 69 (4.5%) underwent NIV. Main outcome measures Predictors hospital mortality. Results The rate...
Objective: A considerable part of COVID-19 patients were found to be re-positive in the SARS-CoV-2 RT-PCR test after discharge. Early prediction cases is critical importance determining isolation period and developing clinical protocols. Materials Methods: Ninety-one discharged from Wanzhou Three Gorges Central Hospital, Chongqing, China, February 10, 2020 March 3, administered nasopharyngeal swab tests within 12–14 days, 50 eligible (32 male 18 female) with completed data enrolled. Average...