A5067277515- Clinical Laboratory Practices and Quality Control
- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Stress Responses and Cortisol
- Adrenal Hormones and Disorders
- Parathyroid Disorders and Treatments
- Meta-analysis and systematic reviews
- Thyroid Cancer Diagnosis and Treatment
- Renal function and acid-base balance
- Bone health and treatments
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Hemoglobinopathies and Related Disorders
- Sepsis Diagnosis and Treatment
- Folate and B Vitamins Research
- Clinical Reasoning and Diagnostic Skills
- Hemodynamic Monitoring and Therapy
- Blood disorders and treatments
- Diabetes and associated disorders
- Adrenal and Paraganglionic Tumors
- Hormonal and reproductive studies
- Diabetes Management and Research
- Vitamin D Research Studies
- Methemoglobinemia and Tumor Lysis Syndrome
- Potassium and Related Disorders
The Royal Wolverhampton NHS Trust
2016-2025
University Hospitals Birmingham NHS Foundation Trust
2022-2024
Heartlands Hospital
2024
New Cross Hospital
2021-2023
Wolverhampton Hospital
2021
We describe the utility of ‘folic and folinic acid load tests’ in investigation a 26-year-old woman with persistently low serum folate moderate hyperhomocysteinaemia unresponsive to folic supplements. Serum folate, plasma 5-methyltetrahydrofolate (5-MTHF), red cell 5-MTHF total homocysteine at baseline, 2-h, 4-h 2- or 4-days (if applicable) post administration large dose oral acid, parenteral were measured. The tests confirmed non-compliance but also suggested an unsuspected possible defect...
Abstract Objectives To study the prevalence of trisodium citrate (Na 3 Citrate) contamination in hypernatraemic serum samples by direct measurement and to evaluate performance indirect markers for identification Na Citrate contamination. Methods Serum was measured all (sodium ≥148 mmol/L) over a three-month period. The chloride, sodium-chloride gap, ion selective electrode (ISE)-direct ISE sodium disparity osmolar gap contaminated assessed against ‘gold-standard’ measurement. Results In...
Abstract The ultimate goal of harmonization, crucial to quality in laboratory medicine, is improve patient outcomes by providing accurate, actionable information. Patients and healthcare professionals assume that clinical tests performed different laboratories at times on the same type sample are comparable, results can be reliably consistently interpreted. In this context reporting units for have a considerable influence numeric result. harmonization measurement report, leads provision...
Abstract Objective We assessed the commutativity of Roche and Abbott thyroid assays in diagnosis management subclinical hypothyroidism (SCH). The are used by approximately 75% clinical laboratories UK. Method Consecutive samples received from primary care on patients with SCH who had a raised thyroid‐stimulating hormone (TSH) <10 mIU/L normal free thyroxine (fT4) two using either or were identified over 10 working days. Following identification, analysed at other site within 24 hours....
We assessed the impact of intact parathyroid hormone (iPTH) and adjusted calcium analyses on Abbott, Roche Siemens analytical platforms in diagnosis normocalcaemic primary hyperparathyroidism (NCPHPT). These assays are used by over 85% clinical laboratories UK. Over five months, consecutive serum samples from outpatients with NCPHPT laboratory Abbott were identified, aliquoted stored at -80°C. Frozen aliquots transported monthly to other two laboratories. After thawing, mixed analysed...
Abstract Background PTH assays are not standardized; therefore, method-specific reference intervals required for interpretation of results. increases with age in adults but age-related the Abbott intact (iPTH) assay available. Methods Deidentified serum results from September 2015 to November 2022 were retrieved laboratory information system a serving cosmopolitan population central-west England individuals aged 18 years and older if estimated glomerular filtration rate was ≥60 mL/min,...
Serum total testosterone (T) decreases postprandially. Postprandial salivary (SalT) responses, however, have not been studied. We report on the effect of glucose ingestion fasting SalT concentrations.
To evaluate 99th percentile upper reference limits (URLs) and investigate ethnic differences for the Abbott Architect high-sensitivity cardiac troponin I (hs-cTnI) in a middle-aged to elderly cosmopolitan population.In subjects without cardiovascular disease after outlier exclusion, data on hs-cTnI from 149 white men, 150 women, South Asian (SA) men SA women their sixth, seventh eight decades were analysed. Each ethnicity-gender-decade subgroup consisted of 50 patients except sixth decade...
Background The 0.25 mg short synacthen test is used to assess recovery from hypothalamic–pituitary–adrenal suppression due chronic glucocorticoid administration. We assessed the potential role of salivary cortisol and cortisone in predicting function using as gold standard test. Method Between 09:00 10:30, blood samples were collected just prior a axis patients previously treated with oral glucocorticoids. cut-off for normal was 30-min ≥450 nmol/L. Results Fifty-six tests performed on 47...
Background We compared the effect of haemolysis in sodium measurement using indirect and direct ion-selective electrodes to test hypothesis that haemolytic on would be greater with electrode due electrolyte exclusion from released intracellular proteins. Methods Plasma lithium heparin samples ( n = 36) four volunteers were prepared give a range indices (H-indices). Samples analysed for by electrode, H-index total protein an Abbott Architect c16000 Siemens RAPIDPoint 500. Percentage changes...
Thyroid stimulating hormone (TSH) assays provided by Abbott Laboratories and Roche Diagnostics are used approximately 75% of laboratories in the UK. We assessed potential impact TSH assay differences on biochemical assessment levothyroxine replacement primary hypothyroidism.Samples from 100 consecutive care patients (83 women, median age 64 years, IQR 51-73 years) with hypothyroidism adequate based an Architect reference range were analysed for cobas within 24 hours. The results compared....
Glycation of serum proteins has been proposed as an important mechanism complications diabetes but whether there are differences in glycation different and it any correlation with development microvascular not studied depth. This study aimed to assess level fructosamine, glycated albumin β-lipoprotein type 2 mellitus patients without find out their complications.Case-control involving 150 individuals at a tertiary care hospital western India. Fifty participants were healthy controls (group...
Objective: Narrative literature review of medication and alcohol related hypoglycaemia.Background: Drugs are the commonest causes hypoglycaemia account for a significant number emergency department attendances hospital admissions.Methods: Hypoglycaemia risk with various drug classes is discussed along underlying mechanisms, characteristics caveats around diagnosis management.Conclusions: most common insulin treatment in type 1 diabetes but 2 diabetes, sulphonylureas, other...
Hyperthyroidism has a major impact on mental health.We intended to determine the magnitude of unmet need for health support in patients with hyperthyroidism attending an endocrinology clinic.General Hospital Endocrine Department, Prospective Study.In naturalistic, prospective study, consecutive (n = 176) hyperthyroid were assessed anxiety (generalized disorder, GAD-7), depression (Patient Health Questionnaire PHQ-9), functional impairment (work and social adjustment scale, WSAS), quality...
Haemolysis has been reported as having a positive, negative or no effect on plasma sodium (PNa) and chloride (PCl). We investigated the haemoltytic of different haemolysis protocols PNa PCl using modelling laboratory experiments.In experiment, percentage change recovery due to dilution in routinely (in vitro) haemolysed samples were compared against shear stress spiked with haemolysate from whole blood freeze-thaw, packed cells freeze-thaw osmotic shock protocols. The results control base...
BackgroundInaccurate blood pressure classification results in inappropriate treatment. We tested if machine learning (ML), using routine clinical data, can serve as a reliable alternative to Ambulatory Blood Pressure Monitoring (ABPM) classifying status.MethodsThis study employed multi-centre approach involving three derivation cohorts from Glasgow, Gdańsk, and Birmingham, fourth independent evaluation cohort. ML models were trained office BP, ABPM, clinical, laboratory, demographic...
A 53-year-old man presented to his optician with blurring of vision in the right eye and was diagnosed have branch retinal vein occlusion. Over following 3 months, he had further progressive visual impairment due central occlusion (CRVO) then left CRVO. Soon thereafter, during a hospital admission for infected submandibular gland, noted secondary hypothyroidism persistent hypokalaemia which led diagnosis Cushing’s syndrome. This case unusual as patient did not manifest any classical features...