A5016507795- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Amino Acid Enzymes and Metabolism
- Pain Management and Opioid Use
- Neuropeptides and Animal Physiology
- Substance Abuse Treatment and Outcomes
- Tryptophan and brain disorders
- Alcohol Consumption and Health Effects
- Receptor Mechanisms and Signaling
- RNA and protein synthesis mechanisms
- Pharmacogenetics and Drug Metabolism
- Cannabis and Cannabinoid Research
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Opioid Use Disorder Treatment
- Electroconvulsive Therapy Studies
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- HIV-related health complications and treatments
- Genomics and Rare Diseases
- Vagus Nerve Stimulation Research
- Protein Tyrosine Phosphatases
Zucker Hillside Hospital
2015-2025
Northwell Health
2017-2025
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2021-2025
Creedmoor Psychiatric Center
2024
New York State Office of Mental Health
2024
Columbia University
2010-2024
Feinstein Institute for Medical Research
2015-2021
Hofstra University
2015-2020
Long Island Jewish Medical Center
2015
Research Foundation For Mental Hygiene
2014
Previous studies demonstrated that antidepressant treatment increases the expression of brain-derived neurotrophic factor (BDNF) in rat hippocampus. The present study was conducted to test hypothesis BDNF hippocampus produces an effect behavioral models depression, learned helplessness (LH) and forced swim (FST) paradigms. A single bilateral infusion into dentate gyrus produced both LH FST comparable magnitude with repeated systemic administration a chemical antidepressant. These effects...
Objective: Impulsivity is an important characteristic of many psychiatric disorders, including substance‐related disorders. These disinhibitory disorders have a similar underlying genetic diathesis, with each disorder representing different expression the same liability. This study assessed whether there relationship between impulsivity and alcohol dependence, their correlations P3 (P300) amplitude, proposed endophenotype alcoholism. Methods: Healthy control subjects ( n =58) DSM‐IV...
Endophenotypes reflect more proximal effects of genes than diagnostic categories, hence providing a powerful strategy in searching for involved complex psychiatric disorders. There is strong evidence suggesting the P3 amplitude event-related potential (ERP) as an endophenotype risk alcoholism and other disinhibitory Recent studies demonstrated crucial role corticotropin releasing hormone receptor 1 (CRHR1) environmental stress response ethanol self-administration animal models. The aim...
Chronic opioid use disorder patients often also other substances such as amphetamines. The gene-based analysis method was applied in the genomic database obtained from our previous study with 343 methadone maintenance treatment (MMT) patients. We found that gene encoding gamma-aminobutyric acid type A receptors (GABA-A receptor) delta subunit isoforms (GABRD) associated amphetamine heroin dependent under MMT Taiwan. total of 15% tested positive for urine toxicology test. Two genetic variants...
Abstract Evidence suggests the P3 amplitude of event‐related potential and its underlying superimposed oscillations (EROs), primarily in theta (4–5 Hz) delta (1–3 frequencies, as endophenotypes for risk alcoholism other disinhibitory disorders. Major neurochemical substrates contributing to rhythms involve strong GABAergic, cholinergic glutamatergic system interactions. The aim this study was test associations between single nucleotide polymorphisms (SNPs) glutamate receptor genes ERO...
Abstract Background COVID-19 has caused a global pandemic characterized by severe pneumonia. Brain structure abnormality been confirmed in patients the UK biobank [1]. However, it is not clear whether this reversible nor if could be detected early stage of disease. Aims & Objectives In study, pathological effect on brain integrity was monitored through utilization injury bioindicator, neurofilament light chain (NFL) [2]. It can released from into peripheral blood when neuronal axon...
Abstract It has been demonstrated that the opioid peptide dynorphin plays a role in modulating responses to several psychoactive substances including cocaine. Our laboratory and others have found mRNA levels of caudate putamen are elevated after acute or chronic cocaine exposure rats. Recently, 68‐base pair (bp) repeat polymorphism within core promoter region human prodynorphin gene reported occur alleles containing one, two, three, four copies. This contains putative AP‐1 transcription...
Recent evidence suggests hippocampal and possibly cortical atrophy is associated with major depression. Chronic electroconvulsive seizures (ECS) induce brain-derived neurotrophic factor (BDNF) expression sprouting of the mossy fiber pathway in hippocampus, effects that may be related to therapy's (ECT) mechanism action. The objective this study was investigate role NMDA (N-methyl-D-aspartate) receptor mediating ECS-induced BDNF expression. Timm histochemistry situ hybridization methodologies...
Abstract Methadone maintenance therapy is an established treatment for heroin dependence. This study tested the influence of functional genetic polymorphisms in CYP2C19 gene encoding a CYP450 enzyme that contributes to methadone metabolism on dose, plasma concentration, and side effects methadone. Two single nucleotide (SNPs), rs4986893 (exon 4) rs4244285 5), were selected genotyped 366 patients receiving Taiwan. The steady-state concentrations both its EDDP metabolite enantiomers measured....
Methadone is a synthetic opioid that binds to the κ-opioid receptor with low affinity. This study tested hypotheses genetic polymorphisms in 1 (OPRK1) gene region are associated methadone treatment responses Taiwan maintenance (MMT) cohort. Seventeen single nucleotide (SNPs) OPRK1 were selected and genotyped on DNA of 366 MMT patients. Six SNPs from rs7843965 rs1051660 (intron 2 exon 2) significantly body weight (P < 0.007). A haplotype 4 rs7832417-rs16918853-rs702764-rs7817710 (exon intron...
The influence of both acute and chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression mRNAs encoding glial cell line-derived neurotrophic factor (GDNF) its receptors, GFRalpha-1, GFRalpha-2, c-Ret proto-oncogene (RET) in the rat hippocampus was examined by situ hybridization. Two hours after ECS, levels GFRalpha-1 mRNA dentate gyrus were significantly increased. This increase peaked to nearly 3-fold at 6 h ECS returned basal 24 treatment. Chronic (once daily...
There is no countable biomarker for opioid dependence treatment responses thus far. In this study, we recruited Taiwanese methadone maintenance patients to search genes involving the regulatory mechanisms of dose by genome-wide association analyses.
Methadone is a synthetic opioid used as maintenance treatment for patients addicted to heroin. Skin irritation one of the adverse events caused by use. 344 methadone (MMT) were recruited with records and measurements on dose, plasma concentrations, emergent symptom scales (TESS). 15 reported skin irritation. Five SNPs located within NECTIN4 genetic region genotyped. The gene adherens junction interaction pathway was associated dose in pathway-based genome wide association analyses (P =...
Recent reports of a genetic association between restriction fragment length polymorphisms at the D2 dopamine receptor locus (DRD2) on chromosome 11q and alcoholism have suggested involvement protein in aetiology alcoholism, smoking possibly other disorders. These allelic findings been criticized basis possible confounding ethnic with disease differences, allele frequencies subjects controls, fact that some control groups were not screened to exclude or heavy drinking. We observed frequency...