A5103519364- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Chromosomal and Genetic Variations
- Genetic Syndromes and Imprinting
- Genetics and Neurodevelopmental Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Fetal and Pediatric Neurological Disorders
- RNA modifications and cancer
- Teratomas and Epidermoid Cysts
- Tumors and Oncological Cases
- Tea Polyphenols and Effects
- Pain Mechanisms and Treatments
- Bacterial biofilms and quorum sensing
- Helicobacter pylori-related gastroenterology studies
- Antimicrobial Resistance in Staphylococcus
- Assisted Reproductive Technology and Twin Pregnancy
- Bartonella species infections research
- Advanced Glycation End Products research
- Galectins and Cancer Biology
- Hedgehog Signaling Pathway Studies
- Congenital Ear and Nasal Anomalies
- Phagocytosis and Immune Regulation
- Smoking Behavior and Cessation
- Immune responses and vaccinations
- Opioid Use Disorder Treatment
Taiwan Semiconductor Manufacturing Company (Taiwan)
2024
Yangzhou University
2024
Red Cross Hospital
2024
Nanjing Maternity and Child Health Care Hospital
2023
Nanjing Medical University
2023
Beijing Haidian Hospital
2022
National Chung Hsing University
2019
Mackay Memorial Hospital
2010-2013
National Health Research Institutes
2012
University of California, San Francisco
2007
To present prenatal diagnosis and molecular genetic analyses of mosaic trisomy 9.A 35-year-old woman, gravida 3, para 1, underwent amniocentesis at 17 weeks gestation because her advanced maternal age. Amniocentesis revealed a karyotype 47,XX,+9[3]/46,XX[6]. Repeat 19 47,XX,+9[6]/46,XX[19]. At 22 gestation, she was referred to tertiary medical center for counseling, 47,XX,+9[2]/46,XX[22]. Array comparative genomic hybridization analysis uncultured amniocytes no imbalance in chromosome 9....
ABSTRACT Bartonella quintana is a fastidious, gram-negative, rod-shaped bacterium that causes prolonged bacteremia in immunocompetent humans and severe infections immunocompromised individuals. We sought to define the outer membrane subproteome of B. order obtain insight into biology pathogenesis this emerging pathogen identify predominant antigens targeted by human immune system during infection. isolated total proteins identified 60 two-dimensional sodium dodecyl sulfate-polyacrylamide gel...
ABSTRACT Helicobacter pylori must be motile or display chemotaxis to able fully infect mammals, but it is not known how this directed. We disrupted two genes encoding predicted chemoreceptors, tlpA and tlpC. H. mutants lacking either of these are chemotactic in vitro as the wild type mice when they sole infecting strains. In contrast, coinfected with SS1 tlpC mutant type, we find more than after 2 weeks colonization. Neither strain has an growth defect. These results suggest that - -encoded...
To present the perinatal findings and molecular cytogenetic characterization of prenatally detected mosaic r(21). A 29-year-old primigravid woman underwent amniocentesis at 22 weeks' gestation because hyperechogenic cardiac foci intrauterine growth restriction. Amniocentesis revealed a karyotype 46,XY,r(21)[15]/45,XY,–21[5]. The parental karyotypes were normal. requested repeat amniocentesis. Oligonucleotide-based array comparative genomic hybridization was applied to uncultured amniocytes,...
To present prenatal diagnosis and molecular cytogenetic characterization of a de novo interstitial duplication 14q (14q31.3→q32.12) in pregnancy associated with abnormal maternal serum biochemistry.A 19-year-old woman underwent amniocentesis the second trimester because biochemistry. Her husband was 33 years old. At 16 weeks gestation, levels α-fetoprotein, unconjugated estriol, total β-human chorionic gonadotropin, inhibin A were 0.8 multiples median (MoM), 0.84 MoM, 3.06 1.14 respectively,...
To present prenatal molecular cytogenetic diagnosis of mosaicism for terminal 3p deletion and distal 3q duplication using cultured uncultured amniocytes, the association with fetoplacental discrepancy.A 35-year-old primigravid woman was referred genetic counseling at 21 weeks gestation because 20% (5/25 colonies) add(3)(p26) detected by amniocentesis. Repeated amniocenteses were performed. Array comparative genomic hybridization (aCGH) interphase fluorescence in situ (FISH) applied...
To present prenatal diagnosis and molecular genetic analyses of mosaic trisomy 7.A 38-year-old primigravid woman underwent amniocentesis at 19 weeks gestation because her advanced maternal age. Amniocentesis revealed a karyotype 47,XY,+7[26]/46, XY[16]. Repeated 21 47,XY,+7[20]/46,XY[17]. Simultaneous cordocentesis 46,XY in 100/100 cultured lymphocytes. Polymorphic DNA marker uncultured amniocytes cord blood diallelic pattern with seemingly equal biparental inheritance chromosome 7....
To present molecular cytogenetic characterization of prenatally detected inverted duplication and deletion 9p, or inv dup del(9p). A 35-year-old primigravid woman underwent amniocentesis at 16 weeks gestation because advanced maternal age. Amniocentesis revealed a derivative chromosome 9, der(9) with additional material the end short arm one 9. Parental karyotypes were normal. Level II ultrasound showed ventriculomegaly normal male external genitalia. Repeated was performed 20 gestation....
To present prenatal diagnosis and molecular cytogenetic characterization of Wolf-Hirschhorn syndrome (WHS) associated with microduplications at 8p 10p in a fetus an apparently pure 4p deletion. A 35-year-old gravida 2, para 1 woman underwent amniocentesis 18 weeks gestation because advanced maternal age. Her husband was 38 years There no family history congenital malformations. Amniocentesis revealed karyotype 46,XY,del(4p16.1). The parental karyotypes were normal. Array comparative genomic...
To present prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome (sSMC) derived from ring 2 [r(2)]. A 35-year-old woman underwent amniocentesis at 17 weeks gestation, because advanced maternal age. Amniocentesis revealed de novo ring-shaped sSMC in 11 23 colonies cultured amniocytes. Repeated amniocenteses were made. The was characterized by array comparative genomic hybridization (aCGH), interphase fluorescence situ (FISH)...
This study aimed at presenting prenatal diagnosis and molecular cytogenetic characterization of a small supernumerary marker chromosome (sSMC) derived from 8 by fluorescence in situ hybridization (FISH), quantitative fluorescent polymerase chain reaction (QF-PCR), array comparative genomic (aCGH) on uncultured amniocytes.A 32-year-old woman underwent amniocentesis 19 weeks gestation because fetal pyelectasis. Amniocentesis revealed de novo ring-shaped sSMC two 21 colonies cultured...
To present molecular cytogenetic characterization of a prenatally detected duplication 15q26.2 → q26.3 in fetus with overgrowth. A 34-year-old para 0 woman underwent amniocentesis at 18 weeks gestation because advanced maternal age. Amniocentesis revealed derivative chromosome 15, or der(15), additional material the end long arm one 15. Parental karyotypes were normal. Fetal overgrowth was first noted 21 gestation. Repeated performed 22 Array comparative genomic hybridization 4.71-Mb from to...
To present prenatal diagnosis and molecular cytogenetic characterization of a de novo interstitial duplication 11q (11q22.3→q23.3) in pregnancy associated with abnormal maternal serum biochemistry. A 33-year-old woman underwent amniocentesis the second trimester because Her husband was 33 years old. At 17 weeks gestation, levels α-fetoprotein (AFP), unconjugated estriol (uE3), total β-human chorionic gonadotropin (β-hCG), inhibin were 0.65 multiples median (MoM), 0.61 MoM, 0.32 0.55...
Abstract Background Embryo aneuploidy is a main of principal reason pregnancy loss, in vitro fertilization (IVF) failure and birth defects offspring. Previous researchs have demonstrated that Y chromosome AZFc microdeletion was associated with reproduction outcomes, however, the relationship between embryo remains unexplored. Methods This retrospective cohort study enrolled 513 patients 603 cycles reproductive center Nanjing Maternity Child Health Care Hospital from January 1, 2016 to June...
The successful development of Actinic Pattern Mask Inspection (APMI) has enabled the high-volume manufacturing advanced chips, such as N5 and N3, due to production defect-free masks by tsmc's mask shop. This accomplishment can be attributed utilization an innovative Extreme Ultraviolet (EUV) inspector Graphics Processing Unit (GPU)-based defect detection with Artificial Intelligence (AI) assistance. application EUV unleashed pellicle inspection prolong operation periods in wafer foundries....