A5023683392- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Intraoperative Neuromonitoring and Anesthetic Effects
- Corneal surgery and disorders
- Ocular Diseases and Behçet’s Syndrome
- Ocular Surface and Contact Lens
- Ocular Oncology and Treatments
- Optical Coherence Tomography Applications
- Retinal Development and Disorders
- Advanced Drug Delivery Systems
- Systemic Lupus Erythematosus Research
- Cerebral Venous Sinus Thrombosis
- Pituitary Gland Disorders and Treatments
- Lysosomal Storage Disorders Research
- Drug-Induced Ocular Toxicity
- Corneal Surgery and Treatments
- Multiple Sclerosis Research Studies
- Photoacoustic and Ultrasonic Imaging
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Hepatitis B Virus Studies
Federico II University Hospital
2012-2024
University of Naples Federico II
2016-2023
IRCCS Ospedale San Raffaele
2016-2018
Vita-Salute San Raffaele University
2017
Istituti di Ricovero e Cura a Carattere Scientifico
2017
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017
San Raffaele University of Rome
2017
Background: To evaluate retinal vessel density (VD) in macular and peripapillary regions patients with recent onset of multiple sclerosis, at initial demyelinating event (IDE) matched relapsing-remitting sclerosis (RRMS) patients. Methods: We evaluated VD superficial capillary plexus, deep choriocapillaris radial plexus IDE, RRMS healthy controls (HCs) through Optical Coherence Tomography Angiography (OCT-A). Clinical history, including history optic neuritis, Expanded Disability Status...
Significance: A noninvasive method based on surface-enhanced Raman spectroscopy (SERS) of tears was proposed as a support for diagnosing neurodegenerative pathologies, including different forms dementia and Alzheimer’s disease (AD). In this field, timely reliable discrimination diagnosis are critical aspects choosing valid medical therapy, new methods highly required. Aim: The aim is to evince spectral differences in SERS response human from AD affected, mild cognitive impaired (MCI),...
To investigate the effects of eplerenone compared to observation in treatment acute central serous chorioretinopathy (CSC).Charts consecutive patients with a diagnosis CSC (visual symptoms < 12 weeks) were reviewed. Included divided into group (treated eplerenone) and control (observation). Main outcome measures included changes best-corrected visual acuity (BCVA), macular thickness (CMT), height subretinal fluid (SRF) subfoveal choroidal (CT) at 1 3 months two groups.Fifteen eyes 15 (2...
To assess the presence of retinal vascular network abnormalities in amnestic mild cognitive impairment (aMCI) patients and healthy subjects (HS) through optical coherence tomography angiography (OCTA).OCTA SD-OCT were performed aMCI normal HS. A complete neuropsychological evaluation was performed. Differences vessel density (VD) each plexus foveal avascular zone (FAZ) evaluated with linear mixed model after correction for age, sex disease duration.Twenty-seven (10 Single domain aMCI, 17...
To analyse choroidal vascular density of affected and non-affected areas in active inactive serpiginouschoroiditis (SC) by means optical coherence tomography angiography (OCT-A).In this cross-sectional observational study, 22 eyes 11 patients diagnosed with SC were included. All underwent blue-light fundus autofluorescence (spectralis Heidelberg retinalangiography+OCT) swept-source OCT-A (AngioPlex Elite 9000 SS-OCT, Carl Zeiss Meditech) to qualitative features vessel considered affected,...
The aim of the present study is to analyze changes in retinal vessel density (VD), using Optical Coherence Tomography Angiography (OCT-A), patients that received endoscopic endonasal approach for removal an intra-suprasellar pituitary adenoma compressing optic chiasm.
Uveal melanoma is the most common primary intraocular malignancy. The aim of this retrospective study was to report results after ruthenium-106 (Ru-106) plaque brachytherapy for uveal in terms tumor control, visual acuity, radiation-related complications, recurrence, metastases, and patients' survival rate during 4 years' follow-up. A total 355 eyes from patients have been treated with Ru-106 between February 2011 March 2020. Five were lost follow-up, then 350 (mean age 58 ± 11 years)...
Background: Fabry disease (FD) is a X-linked recessive lysosomal storage disorder characterized by altered biodegradation of glycosphingolipids. It multisystem pathology, also involving ophthalmological systems that show modifications the vessel wall due to glycosphingolipid deposits. Optical coherence tomography angiography (OCT-A) allows for an objective analysis retinal microvasculature alterations, evaluating density in macular region. Methods: A total 54 FD patients (34 females, 20...
Tears are exceptionally rich sources of information on the health status eyes, as well whole body functionality, due to presence a large variety salts and organic components whose concentration can be altered by pathologies, eye diseases and/or inflammatory processes. Surface enhanced Raman spectroscopy (SERS) provides unique method for analyzing low concentrations fluids such tears. In this work, home-made colloid gold nanoparticles has been used preparing glass substrates able efficiently...
The aim of this study was to evaluate retinal and choriocapillaris (CC) vessel density, using optical coherence tomography angiography (OCTA), in the macular region at baseline after three once-monthly intravitreal injections bevacizumab (loading phase) patients affected by exudative age-related degeneration (AMD). A total 38 eyes with AMD (16 women, 22 men; mean age 72.47 ± 7.46 years) were included study. We evaluated density different areas (whole image, fovea parafovea) superficial...
Choroidal metastasis represents the most common malignant intraocular tumours.The objective of this study is to detect structural and vascular features choroidal by multimodal imaging.Sixteen eyes 16 patients with were enrolled in prospective study. The imaging was performed all patients: fluorescein angiography, indocyanine green enhanced depth optical coherence tomography (EDI-OCT), OCT angiography (OCTA), ultrasonography.The located macula region 9 (57%) extramacular 7 (43%). EDI-OCT...
We evaluated spectral-domain optical coherence tomography (SD-OCT) parameters and visual field in patients with different degrees of open-angle glaucoma (preperimetric, mild, moderate, severe glaucoma) to determine which parameter best identifies each glaucomatous group.A total 131 (66 preperimetric, 41 35 40 eyes) normal eyes (control group) were included this prospective study. The SD-OCT [mean ganglion cell complex (GCC), superior GCC, inferior global loss volume, focal mean...
Purpose To evaluate the retinal vessel density (VD) in macular region and foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) patients with without disorganization of inner layers (DRILs) after resolution diabetic edema. Methods Thirty-seven eyes 37 DRIL (mean age 63 ± 13.97 years), 30 no 35 controls were enrolled this study. We evaluated VD superficial capillary plexus (SCP), deep (DCP) FAZ area. Results groups showed decreased SCP DCP (p<0.05) a larger...
To measure corneal epithelial thickness (CET) in patients with glaucoma using anterior-segment optical coherence tomography and to evaluate CET changes relation microvilli analyzed by scanning electron microscopy (SEM).Twenty-two eyes (16 patients) being treated preservative-containing topical medications 12 normal underwent imaging RTVue-100. The maps generated corresponded a 6-mm diameter area of cornea that was divided into 17 sectors. We compared the CETs each sector obtained...
Abstract The corneal epithelium represents one of the main structures that undergo degenerative alterations due to antiglaucomatous therapy. Chronic glaucoma therapy containing benzalkonium chloride induces epithelial cellular changes and inflammatory infiltration in turn causes ocular surface resulting discomfort. Also, age‐related can involve tear film stability with reduction microvilli. objective this study is gain insights about glaucomatous patients divided according age, type duration...
In this prospective study, we analysed the changes in retinal vessel density (VD) using optical coherence tomography angiography (OCTA) patients with commotio retinae up to 6 months after blunt ocular trauma. We VD superficial capillary plexus (SCP), deep (DCP), radial peripapillary (RPC) and foveal avascular zone (FAZ) area at 48 h, 1, 3 trauma compared results those of healthy fellow eyes. also evaluated best-corrected visual acuity (BCVA) structural, spectral domain (SD)-OCT parameters:...
Optical Coherence Tomography Angiography (OCTA) abnormalities occur in multiple sclerosis (MS) over the course of disease. OCTA investigations at early MS stages are lacking. We aimed to investigate vessel density macular and papillary regions two years after an initial demyelinating event (IDE). Vessel was analyzed superficial, deep, choriocapillaris radial peripapillary plexus baseline, one years. also evaluated structural OCT parameter changes ganglion cell complex (GCC) retinal nerve...
Abnormalities in retinal vascularization and neural density have been found many neurodegenerative diseases; however, conflicting results are described Amyotrophic Lateral Sclerosis (ALS). The aim of the present study was, therefore, to systematically analyze layers by means spectral-domain (SD-OCT) optical coherence tomography angiography (OCT-A) ALS patients. We enrolled 48 patients 45 healthy controls. were divided into three groups: slow progressors (n = 10), intermediate 24) fast 14),...