A5103221199- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heme Oxygenase-1 and Carbon Monoxide
- Pharmacology and Obesity Treatment
- Diabetes and associated disorders
- High Altitude and Hypoxia
- Peroxisome Proliferator-Activated Receptors
- Neonatal Health and Biochemistry
- Biological and pharmacological studies of plants
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Endoplasmic Reticulum Stress and Disease
- Diabetes Management and Education
- Thyroid Disorders and Treatments
- RNA modifications and cancer
- AI in cancer detection
- Machine Learning in Bioinformatics
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Folate and B Vitamins Research
- Biological Research and Disease Studies
- Biochemical effects in animals
Peking University People's Hospital
2016-2024
Peking University
2016-2024
Guizhou University
2024
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammatory cell infiltration, which can lead to disability, joint destruction and loss of function. At present, the pathogenesis RA still unclear. The purpose this study explore potential biomarkers immune molecular mechanisms rheumatoid through machine learning-assisted bioinformatics analysis, in order provide reference for early diagnosis treatment disease.
Abstract To identify the factors associated with serum total bilirubin (STB) and determine whether STB is independently diabetic retinopathy (DR) or kidney disease (DKD), 1,665 Chinese patients type 2 diabetes (T2DM) (248 outpatients newly diagnosed T2DM [NDM] 1,417 inpatients previously [PDM]) were studied. Clinical biochemical information was collected, a single nucleotide polymorphism (rs6704078) of UGT1A1 gene genotyped in 1,059 individuals. Multiple linear regression showed that...
Abstract Diabetes is one of the most common phenotypes Wolfram syndrome owing to presence variants WFS1 gene and often misdiagnosed as other types diabetes. We aimed explore prevalence WFS1-related diabetes (WFS1-DM) its clinical characteristics in a Chinese population with early-onset type 2 (EOD). sequenced all exons 690 patients EOD (age at diagnosis ≤ 40 years) for rare variants. Pathogenicity was defined according standards guidelines American College Medical Genetics Genomics....
Plant-derived medicinal materials have significant potential and promising applications in wound healing skin regeneration. This study aims to develop a plant-based extract hydrogel from Bletilla striata (Thunb.Reichb.f.), specifically glucosyloxybenzyl 2-isobutylmalates (B), characterize its effects on healing. We synthesized the using carbomer (C), glycerol (G), triethanolamine (T) as matrix, incorporating B into base, evaluated physical chemical properties. In vitro tests assessed...
Sorbin and SH3-domain-containing-1 (SORBS1) play important roles in insulin signalling cytoskeleton regulation. Variants of the SORBS1 gene have been inconsistently reported to be associated with type 2 diabetes or diabetic kidney disease (DKD).Two independent case-control studies based on two randomized sampling cohorts (cohort 1, n = 3345; cohort 2, 2282) were used confirm association between rs2281939 impaired glucose regulation (IGR). An additional hospital-based 3, 2135) 1 investigate...
PPARγ variants cause lipodystrophy, insulin resistance, and diabetes. This study aimed to determine the relationship between genotypes phenotypes explore pathogenesis of diabetes beyond this relationship. PPARγ2 exons in 1,002 Chinese patients with early-onset type 2 (diagnosed before 40 years age) were sequenced. The functions evaluated by vitro assays. Additionally, a review literature was performed obtain all reported cases rare evaluate characteristics different functional domains. Six...
Abstract Background The association between adrenal size and metabolic profiles in patients with diabetes mellitus (DM) is unclear. This study was conducted to determine whether the thickness measured by computed tomography (CT) correlated of DM. Methods a cross‐sectional including 588 Chinese hospitalized DM without comorbidities or medications known affect morphology hormone secretion. Adrenal limb on unenhanced chest CT. Participants were stratified into tertiles according their total...
The hemoglobin A1c (HbA1c) test is a standard for diabetes screening and diagnosis.To evaluate performance in high-altitude polycythemia compared to population with high proportion of people living an oxygen-deficient environment.A population-based epidemiological survey was conducted.The cities Lhasa Shigatse were selected. Volunteers recruited through educational advertisements about diabetes.A total 1401 Tibetan adults without known diabetes.Oral glucose tolerance (OGTT), HbA1c, complete...
Vasoactive intestinal peptideoma (VIPoma) is a rare pancreatic endocrine tumor associated with well‑defined clinical syndrome characterized by watery diarrhea, hypokalemia and metabolic acidosis. In adults, VIPoma most commonly found in the pancreas, 80% of tumors occurring body tail 20% head. VIPomas can represent significant diagnostic challenge due to their nonspecific presentation, which result misdiagnosis as another condition, such laxative overdose or carcinoid secreting tumor....
Objectives Mitochondrial DNA (mtDNA) plays an important role in the pathogenesis of diabetes. Variants mtDNA have been reported diabetes, but studies on whole variants were limited. Our study aims to explore association with diabetes and diabetic kidney disease (DKD). Methods The mitochondrial genome was screened by next-generation sequencing cohort 1 consisting 50 early-onset (EOD) patients a maternally inherited (MID) family history. A total 42 possibly associated diseases identified...
Objective Graves’ disease (GD) and autoimmune thyroiditis (AIT) are two major causes of thyrotoxicosis that require correct diagnosis to plan appropriate treatment. The objectives this study were evaluate the usefulness thyroid-related parameters for distinguishing GD from AIT identify a novel index differential thyrotoxicosis. Design This retrospective was performed using electronic medical records in Peking University People’s Hospital (Beijing, China). Methods In total, 650 patients with...
Objective To evaluate the placebo effect of hypoglycemic treatment in Chinese type 2 diabetes patients. Methods The MEDLINE, EMBASE, CENTRAL databases were searched and qualified studies included. All double blind, placebo-controlled randomized trials patients; patients age≥18 years; duration follow-up study ≥12 weeks with efficacy evaluated by changes glycated hemoglobin A1c (HbA1c) or fasting plasma glucose (FPG) from baseline groups. References collected until Dec. 2013....
Objective To investigate whether sulfonylurea(SU)increases the risk of stroke in patients with type 2 diabetes mellitus(T2DM). Methods A systemic meta-analysis including 17 random control trails(RCT)was performed to compare between diabetic treated SUs and comparators. Results 1 612 articles were retrieved, finally included. Patients receiving treatment had a higher relative stroke(RR 1.35, 95%CI 1.13-1.60)than those who received comparators. The I2 statistic for heterogeneity...
This study aimed to investigate the clinical implications of fasting serum insulin (FINS) levels in subjects with type 2 diabetes who were receiving therapy.A total 1,553 [774 had never received treatment (N-INS) and 779 therapy (constant treatment, C-INS)] admitted Department Endocrinology Metabolism Peking University People's Hospital enrolled this study. Their FINS measured those hyperinsulinemia identified. The underlying mechanisms revealed by measuring antibodies (IAs) analyzing...