A5100776768- Viral-associated cancers and disorders
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Obesity, Physical Activity, Diet
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Herpesvirus Infections and Treatments
- Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Cancer Cells and Metastasis
- Polyomavirus and related diseases
- Prostate Cancer Treatment and Research
- Head and Neck Cancer Studies
- Nutritional Studies and Diet
- Smoking Behavior and Cessation
- Diet and metabolism studies
- Nutrition, Health and Food Behavior
- Cardiac, Anesthesia and Surgical Outcomes
- Prostate Cancer Diagnosis and Treatment
- Health Policy Implementation Science
- Pancreatitis Pathology and Treatment
- Chronic Lymphocytic Leukemia Research
- Trauma and Emergency Care Studies
- 3D Printing in Biomedical Research
- Pancreatic and Hepatic Oncology Research
- Histiocytic Disorders and Treatments
University of Toronto
2021-2024
Duke University
2024
Trinity College
2024
Princess Margaret Cancer Centre
2020-2024
University Health Network
2020-2024
Johns Hopkins University
2024
University of California, San Diego
2021-2023
University of California San Diego Medical Center
2023
Madigan Army Medical Center
2021
University of North Carolina Health Care
2021
As of 18 October 2020, over 39.5 million cases coronavirus disease 2019 (COVID-19) and 1.1 associated deaths have been reported worldwide. It is crucial to understand the effect social determination health on novel COVID-19 outcomes in order establish justice. There an imperative need, for policy makers at all levels, consider socioeconomic racial ethnic disparities pandemic planning. Cross-sectional analysis from COVID Boston University's Center Antiracist Research Racial Data Tracker was...
Summary Background Magnetic resonance elastography (MRE) is a reliable non‐invasive alternative to liver biopsy for assessing fibrosis. There are limited data regarding an association between fibrosis by MRE and risk of cardiovascular disease (CVD). Aim To investigate the high‐risk CVD phenotype determined coronary artery calcification (CAC) with in patients non‐alcoholic fatty (NAFLD). Method This was cross‐sectional analysis well‐characterised, prospective cohorts including 105 NAFLD (MR...
Abstract Folate is essential for nucleotide synthesis, DNA replication, and methyl group supply. Low-folate status has been associated with increased risks of several cancer types, suggesting a chemopreventive role folate. However, recent findings on giving folic acid to patients history colorectal polyps raise concerns about the efficacy safety folate supplementation long-term health effects fortification. Results suggest that undetected precursor lesions may progress under supplementation,...
Scope The importance of folate‐mediated one‐carbon metabolism ( FOCM ) in colorectal carcinogenesis is emphasized by observations that high dietary folate intake associated with decreased risk colon cancer CC and its precursors. Additionally, polymorphisms ‐related genes have been repeatedly risk, supporting a causal relationship between carcinogenesis. Methods results We investigated ten candidate defined or probable functional impact eight SHMT 1, DHFR , DNMT MTHFD MTHFR MTRR TCN 2, TDG...
The immune system plays a crucial role in cancer surveillance. Previous studies have shown that lymphopenia associated with radiotherapy (RT) portends poor prognosis. We sought to differentiate the effects of proton and photon RT on changes absolute lymphocyte count (ALC) for patients hepatocellular carcinoma (HCC).Patients HCC treated definitive from 2006 2016 were studied. Serial ALCs graded according CTCAE v4.0. Overall survival (OS), disease-free survival, distant metastasis-free...
Abstract Background: Endogenous retrotransposable elements (EREs) can modulate antitumor immune responses via viral mimicry response. We previously described an association between ERE upregulation and radiological response to checkpoint blockade (ICB) in advanced solid tumors the phase II INSPIRE trial (NCT02644369) (ASCO 2024). Here, we validate of EREs ICB two independent cohorts patients (pts) with melanoma non-small cell lung cancer (NSCLC) treated ICB. Methods: Publicly available...
Clinical trials are a critical resource for the discovery of new prevention, diagnostic, and treatment methods cancer. The most effective prevention modalities based on previous clinical trial results. However, participation in is underrepresented by racial/ethnic minority populations, Asian Americans particular. least represented any ethnic groups trials. purpose this study to develop evaluate culturally linguistically appropriate community-based educational intervention increase knowledge...
Summary Background Variants in multiple genetic loci modify the risk of non‐alcoholic fatty liver disease (NAFLD) and cirrhosis but there are limited data on quantitative impact variant copies fibrosis. Aim To investigate effect PNPLA3, TM6SF2, MBOAT7, GCKR HSD17B13 genotype fibrosis assessed by magnetic resonance elastography (MRE), a reproducible, accurate, continuous biomarker Methods This is cross‐sectional analysis derived from well‐characterised cohort at for NAFLD who underwent...
Abstract Low-folate status and genetic polymorphisms in folate metabolism have been linked to several cancers. Possible biological mechanisms for this association include effects on purine thymidine synthesis, DNA methylation, or homocysteine concentrations. The influence of variation these putative biomarkers cancer risk has largely unexplored. We used a mathematical model that simulates biochemistry predict (a) the with defined enzyme function (MTHFR TS) (b) potential,...
Geographically dispersed patients, inconsistent treatment tracking, and limited infrastructure slow research for many orphan diseases. We assess the feasibility of a patient-powered study design to overcome these challenges Castleman disease, rare hematologic disorder. Here, we report initial results from ACCELERATE natural history registry. includes traditional physician-reported arm arm, which enables patients directly contribute medical data biospecimens. This successful enrollment, with...
This report summarizes the identification and synthesis of novel LpxC inhibitors aided by computational methods that leveraged numerous crystal structures. effort led to oxazolidinone isoxazoline with potent in vitro activity against P. aeruginosa other Gram-negative bacteria. Representative compound 13f demonstrated efficacy a mouse neutropenic thigh infection model. The antibacterial K. pneumoniae could be potentiated Gram-positive antibiotics rifampicin (RIF) vancomycin (VAN) both vivo models.
This paper describes mammary organoids with a basal-in phenotype where the basement membrane is located on interior surface of organoid. A key materials consideration to induce this use minimal gel scaffold that epithelial cells self-assemble around and encapsulate. When MDA-MB-231 breast cancer are co-cultured from day 0 under these conditions, self-organize into patterns distinct cell populations both inside at periphery In another type experiment, robust formation organoid enables...
Introduction: Two-dimensional shear wave elastography (2D-SWE) and vibration-controlled transient (VCTE) provide noninvasive assessment of hepatic fibrosis. We compared performance 2D-SWE VCTE for fibrosis detection in nonalcoholic fatty liver disease (NAFLD). Methods: performed a prospective study adults with NAFLD who underwent 2D-SWE, VCTE, biopsy analysis (using Nonalcoholic Steatohepatitis Clinical Research Network scoring system). The primary outcome was (stage ⩾ 1); secondary outcomes...
Pulmonary lymphangioleiomyomatosis (LAM), a rare progressive lung disease associated with mutations of the tuberous sclerosis complex 2 ( Tsc2) tumor suppressor gene, manifests by neoplastic growth LAM cells, induction cystic destruction, and respiratory failure. severity correlates upregulation in serum prolymphangiogenic vascular endothelial factor D (VEGF-D) that distinguishes from other diseases. The goals our study was to determine whether Tsc2 deficiency upregulates VEGF-D, axitinib,...
Three-dimensional (3D) tissue models such as epithelial spheroids or organoids have become popular for pre-clinical drug studies. In contrast to 2D monolayer culture, the characterization of 3D from non-invasive brightfield images is a significant challenge. To address this issue, here we report deep-learning uncovered measurement networks (Deep-LUMEN) assay. Deep-LUMEN an object detection algorithm that has been fine-tuned automatically uncover subtle differences in spheroid morphology...
Abstract Purpose The risk of developing head and neck squamous cell carcinoma (HNSCC) in patients with graft versus host disease (GVHD) after bone marrow transplant (BMT) is well established but large series reporting outcomes are sparse. Methods Retrospective, single institution, study GVHD HNSCC BMT, between January 1, 1968, June 30, 2016. Results In total, 25 were studied, which 21 (84%) male 4 (16%) female. Mean age for BMT was 41 (18‐65) years. All developed GVHD, most common site oral...
Previous research has identified differences in e-cigarette use and socioeconomic factors between different racial groups However, there is little examining specific risk contributing to the differences. This study sought identify disparities determine that help explain these We used Wave 5 (2018-2019) of Adult Population Assessment Tobacco Health (PATH) Study. First, we conducted descriptive statistics e-smoking across our factor variables. Next, multiple logistic regression check effects...
Background. The synergy between herpes simplex virus type 2 (HSV-2) and human immunodeficiency 1 (HIV-1) is well known, but lack of knowledge about the epidemiology HSV-2 acquisition in HIV-1-discordant couples hampers development prevention interventions that could reduce HIV-1 transmission. Methods. were enrolled Nairobi, Kenya, followed for up to years. status was determined using HerpeSelect ELISA. Correlates prevalence incidence assessed. Results. Of 469 couples, at baseline, 353...
CC49 is a clinically validated antibody with specificity for TAG-72, carbohydrate epitope that over-expressed and exposed on large fraction of solid malignancies. We constructed single chain fragment (scFv) based fused it to β-lactamase. The first generation fusion protein, TAB2.4, was expressed at low levels in Escherichia coli significant degradation observed during production. optimized the scFv domain TAB2.4 by Combinatorial Consensus Mutagenesis (CCM). An improved variant TAB2.5...