A5102744248- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Head and Neck Surgical Oncology
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Extracellular vesicles in disease
- Arsenic contamination and mitigation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Enhanced Recovery After Surgery
- Nausea and vomiting management
- Medical Research and Treatments
- Diabetes Treatment and Management
- Pelvic floor disorders treatments
- Cancer Risks and Factors
- Cardiac Fibrosis and Remodeling
- Intraoperative Neuromonitoring and Anesthetic Effects
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gout, Hyperuricemia, Uric Acid
- Biomarkers in Disease Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
Zhejiang Hospital
2015-2025
Huazhong University of Science and Technology
2023
Hubei Cancer Hospital
2023
Qilu Hospital of Shandong University
2012-2016
Ministry of Education of the People's Republic of China
2013-2015
Shandong Provincial Hospital
2015
Shandong University
2013
Environmental Protection Agency
2006
Background Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is associated with metabolic disorder and cell death, which are important triggers in diabetic cardiomyopathy (DCM). We aimed to explore whether NLRP3 activation contributes DCM the mechanism involved. Methods Type 2 rat model was induced by high fat diet low dose streptozotocin. The characteristics of type were evaluated tests, echocardiography histopathology. Gene silencing therapy used...
Abstract miRs (microRNAs, miRNAs) intricately regulate physiological and pathological processes. Although miR-7a/b protects against cardiomyocyte injury in ischemia/reperfusion injury, the function of myocardial infarction (MI)-induced cardiac remodeling remains unclear. Here, we sought to investigate post-MI a mouse model determine underlying mechanisms involved. overexpression improved function, attenuated reduced fibrosis apoptosis, whereas silencing caused opposite effects. Furthermore,...
MicroRNA-7a/b (miR-7a/b) protects cardiac myocytes from apoptosis during ischemia/reperfusion injury; however, its role in angiotensin II (ANG II)-stimulated fibroblasts (CFs) remains unknown. Therefore, the present study investigated anti-fibrotic mechanism of miR-7a/b ANG II-treated CFs. stimulated expression specific protein 1 (Sp1) and collagen I a dose- time-dependent manner, overexpression significantly down-regulated Sp1 by (100 nM) for 24 h. effectively inhibited MMP-2...
Introduction: Ketamine is commonly used in pediatric anesthesia but recent studies have shown that it could induce neurotoxicity the developing brain.The inflammatory cytokine, tumor necrosis factor α (TNF-α) involved pathogenesis of various types neurodegenerations.In present study, we examined whether TNF-α may regulate ketamine-induced hippocampus neonatal mouse.Material and methods: The vitro organotypic culture hippocampal slices was to investigate gain-of-function loss-of-function...
Objective The ideal agents for conscious sedation during ambulatory inguinal hernia repair are still unclear. We aimed to compare the analgesic, sedative, haemodynamic, and side effects of dexmedetomidine with those propofol in combination fentanyl patients undergoing repair. Methods Eighty unilateral were prospectively randomized receive either (n = 40) or 40). Dexmedetomidine dosages adjusted maintain targeted level sedation. Results After administration sedative drugs, who received had a...
Objective: To observe the analgesic effect, complication and patient satisfaction of Acute Pain Service (APS) after thoracic surgery. Methods: The clinical data were collected from 264 patients who underwent different surgery January 2017 until December 2019 retrospectively. They divided into thoracotomy group (group O) thoracoscopy T). There 90 cases in O 174 T. According to use APS, is no-APS O1) APS O2), T T1) T2). effect postoperative analgesia, incidence nausea vomiting compared between...
Abstract Objective Postoperative fasting following thoracoscopic surgery can cause intense thirst and oral discomfort. However, there is currently no research on ultraearly hydration (UEOH) in middle-aged or elderly patients after surgery. The aim of this study was to investigate the effectiveness safety UEOH for improving discomfort Methods This single-center prospective double-blind randomized controlled trial conducted from April 2022 November 2023. A total 64 who underwent first day were...
Background. Postoperative pain is a major adverse effect of surgery for mixed hemorrhoids. We evaluated whether spinal anesthesia with ropivacaine and hydromorphone provided safe effective analgesia after Methods. This single-center, double-blind pilot study included patients hemorrhoids who underwent procedure prolapse (PPH) external hemorrhoidectomy under at Zhejiang Hospital, China (October 2020 to December 2020). Patients were randomized group (spinal 0.5% 75 μg hydromorphone) or...
To investigate clinical efficacy and experience of total knee arthroplasty in treating osteoarthritis patients with Parkinson's disease.From January 2011 to 2014, 19 disease treated were collected. Among them, including 9 males 10 females aged from 61 83 years old an average 71.3 old. Radiology results checked before after operation. VAS score KSS applied evaluate effects. Patients classified according HoehnYahr grade, 3 cases grade 1, 4 1.5, 2 2, 2.5, 1 case 4.Nineteen followed up 7 4.3...
The present study aimed to evaluate the function of pyrin and interleukin-10 (IL-10) potential mechanisms underlying regulation inflammation in pulmonary vascular endothelial cells (ECs) following hemorrhagic shock (HS). Adult female Sprague-Dawley rats were divided into 4 groups (n=6 each group) examine changes expression HS-lipopolysaccharide (LPS) administration, including groups: A sham operation (SM) + tracheal injection saline (SAL) group; a HS SAL SM LPS group (with endotoxin); group....
With the declassification of Nixon Presidential Materials Project and partial release Chinese sources on U.S.-China rapprochement over past two decades, scholars have studied published works Nixon/Mao-era from different perspectives. For instance, Evelyn Goh evolution United States thinking toward China before after Nixon’s trip in 1972, demonstrating how ideas about reconciliation with were raised debated within U.S. official circles during 1960s. Making use a large array documents, author...