A5102279596- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Exercise and Physiological Responses
- High Altitude and Hypoxia
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Muscle metabolism and nutrition
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Pancreatitis Pathology and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Treatment and Pharmacology
- Knee injuries and reconstruction techniques
- Sirtuins and Resveratrol in Medicine
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diabetes Management and Research
- Pharmacological Effects of Medicinal Plants
- Diabetes and associated disorders
Kunming Medical University
2021-2025
Sixth Affiliated Hospital of Kunming Medical University
2021-2025
Shanghai University of Sport
2013-2024
Guangzhou Medical University
2023
Hebei Normal University
2023
Université Claude Bernard Lyon 1
2022
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2022
First Affiliated Hospital of GuangXi Medical University
2016-2021
Guangxi Medical University
2016-2021
Second Military Medical University
2014-2018
Background Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is associated with metabolic disorder and cell death, which are important triggers in diabetic cardiomyopathy (DCM). We aimed to explore whether NLRP3 activation contributes DCM the mechanism involved. Methods Type 2 rat model was induced by high fat diet low dose streptozotocin. The characteristics of type were evaluated tests, echocardiography histopathology. Gene silencing therapy used...
The anti-inflammatory effect of exercise may be an underlying factor in improving several autoimmune diseases. aim this systematic review was to examine the evidence on role training mitigating inflammation adolescents and adults with disease. PubMed, Web Science, Embase databases were systematically reviewed for related studies published between January 1, 2003 August 31, 2023. All randomized non-randomized controlled trials interventions disease study participants that evaluated...
Bioactive oxidized linoleic acid metabolites (OXLAMs) include 13- and 9-hydroxy-octadecadienoic (13-HODE + 9-HODE) have been linked to oxidative stress, inflammation, numerous pathological physiological states. The purpose of this study was measure changes in plasma 13-HODE 9-HODE following a 75-km cycling bout identify potential linkages linoleate metabolism established biomarkers stress (F2-isoprostanes) inflammation (cytokines) using metabolomics approach. Trained male cyclists (N = 19,...
Chemerin and its receptor CMKLR1 (a G-protein-coupled receptor) are inducers of inflammation, play an important role in diabetic cardiomyopathy (DCM). In this study, we investigated the chemerin/CMKLR1 axis mediating inflammation cell death DCM. Sprague–Dawley rats, treated with a high-fat diet low-dose streptozotocin, were used as DCM model. expression was knocked down by siRNA (CMKLR1-siRNA) to evaluate Chemerin-treated H9c2 cells investigate factors acting downstream axis. LDH release...
Objectives Pistachio nut ingestion (3 oz./d, two weeks) was tested for effects on exercise performance and 21-h post-exercise recovery from inflammation, oxidative stress, immune dysfunction, metabolite shifts. Methods Using a randomized, crossover approach, cyclists (N = 19) engaged in 75-km time trials after 2-weeks pistachio or no supplementation, with 2-week washout period. Subjects came to the lab an overnight fasted state, ingested water only 3 oz. pistachios before during exercise....
This study determined if 6-weeks vitamin D2 supplementation (vitD2, 3800 IU/day) had an influence on muscle function, eccentric exercise-induced damage (EIMD), and delayed onset of soreness (DOMS) in National Association for Stock Car Auto Racing (NASCAR) NASCAR pit crew athletes. Subjects were randomized to vitD2 (n = 13) placebo 15), ingested supplements (double-blind) six weeks. Blood samples collected function tests conducted pre- post-study (leg-back hand grip dynamometer strength...
The purpose of this study was to assess the effect 8-weeks ingestion a commercialized joint pain dietary supplement (InstaflexTM Joint Support, Direct Digital, Charlotte, NC) compared placebo on pain, stiffness, and function in adults with self-reported pain. InstaflexTM is containing glucosamine sulfate, methylsufonlylmethane (MSM), white willow bark extract (15% salicin), ginger root concentrate, boswella serrata (65% boswellic acid), turmeric extract, cayenne, hyaluronic acid. Subjects...
BACKGROUND:Many heart failure (HF) cases are caused by idiopathic dilated cardiomyopathy (iDCM). This study explored the mechanisms of development and progression HF iDCM. MATERIAL AND METHODS:The gene expression profiles 102 samples were downloaded from GEO database (GSE5406). Differentially expressed genes (DEGs) identified through GO analysis a KEGG pathway analysis, respectively. A protein–protein interaction (PPI) network was constructed analyzed to screen potential regulatory proteins....
MSC senescence is considered a contributing factor in aging-related diseases. We investigated the influence of inflammatory microenvironment on bone marrow mesenchymal stem cells (BMSCs) under aging conditions and underlying mechanism to provide new ideas for cell therapy age-related osteoporosis. The BMSCs were cultured until passage 3 (P3) (young group) 10 (P10) (aging vitro. supernatant was collected as conditioned medium (CM). young CM P3 or P10 cells. effects from different groups...
Though the mechanisms of skeletal muscle regeneration are deeply understood, those involved in contusion, one most common injuries sports medicine clinics, not. The objective this study is to explore after contusion injury. In study, a total 72 mice were used. Eight them randomly chosen for control group, while rest subjected contusion. Subsequently, their gastrocnemius muscles harvested at different time points. changes morphology assessed by hematoxylin and eosin (HE) stain. addition, gene...
The nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome is a multiprotein complex consisting of NLRP3, apoptosis-associated speck-like protein containing caspase recruitment domain (ASC) and caspase-1. In peripheral blood mononuclear cells (PBMCs), NLRP3 can activate interleukin-1β (IL-1β), important in the chronic inflammatory process idiopathic dilated cardiomyopathy (IDCM). Therefore, PBMCs may be involved pathogenesis IDCM. We evaluated association circulating...
Exercise induces blood flow redistribution among tissues, leading to splanchnic hypoperfusion. Intestinal epithelial cells are positioned between the anaerobic lumen and highly metabolic lamina propria with an oxygen gradient. Hypoxia-inducible factor (HIF)-1α is pivotal in transcriptional response flux. In this study, pimonidazole hydrochloride staining was applied observe tissue hypoxia different organs, which might be affected by redistribution. The HIF-1α luciferase reporter ROSA26...
Introduction: Serum magnesium is a crucial mineral within the human body. It imperative for diabetic patients to maintain optimal serum levels. We focus on relationship between glycemic control and in type 2 diabetes mellitus (T2DM). Methods: The retrospective, observational, cross-sectional study comprised 1694 recruited from People's Hospital of Yuxi. Fasting blood samples were collected analysis, accompanied by recording participants' demographic characteristics. Patients categorized into...
Hypertension (HTN) is a significant risk factor for cardiovascular disease. Identifying new factors hypertension crucial. This study aims to determine the predictive value of fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) in development hypertension.
A randomized, controlled trial was conducted to determine whether a 6-week low calorie diet and aerobic exercise intervention could alter metabolic syndrome (MetS) risk factors in pre-pubescent obese Chinese children. The subjects were randomized into (DE) control (C) groups. DE group ingested 1600–2000 kcal/day adjusted each participant's basal rate, engaged high-volume (6 days/week, twice daily, for 3 h per session) 6 weeks. total of 215 children between the ages 11 13 years recruited...
Background: Type 2 diabetes mellitus (T2DM) and inflammatory bowel disease (IBD) have been associated, according to various epidemiological research. This study uses Mendelian randomization (MR) investigate the causal link between T2DM IBD. Methods: To relationship IBD risk using European population data from genome-wide association (GWAS) summary datasets, we constructed a two-sample MR evaluate genetically predicted impacts of liability towards outcomes on risk. As instrumental variables...