Verónica Freire-Benéitez
A5009696813- Protist diversity and phylogeny
- Microbial Community Ecology and Physiology
- Marine Ecology and Invasive Species
- RNA Research and Splicing
- DNA Repair Mechanisms
- Sirtuins and Resveratrol in Medicine
- Immunotherapy and Immune Responses
- Antifungal resistance and susceptibility
- Genetics, Aging, and Longevity in Model Organisms
- Toxin Mechanisms and Immunotoxins
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Gut microbiota and health
- Plant Genetic and Mutation Studies
- Tissue Engineering and Regenerative Medicine
- Fungal Infections and Studies
- Genomics and Chromatin Dynamics
- Mechanisms of cancer metastasis
- Bacterial Genetics and Biotechnology
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
Queen Mary University of London
2021
University of Kent
2016-2020
Consejo Superior de Investigaciones Científicas
2014
Abstract Diverse microbial ecosystems underpin life in the sea. Among these microbes are many unicellular eukaryotes that span diversity of eukaryotic tree life. However, genetic tractability has been limited to a few species, which do not represent or environmentally relevant taxa. Here, we report on development tools range protists primarily from marine environments. We present evidence for foreign DNA delivery and expression 13 species never before transformed advancement eight other as...
Transcriptionally silent heterochromatin is associated with repetitive DNA. It poorly understood whether and how differs between different organisms its structure can be remodelled in response to environmental signals. Here, we address this question by analysing the chromatin state DNA repeats human fungal pathogen Candida albicans. Our analyses indicate that, contrary model systems, each type of element assembled into a distinct state. Classical Sir2-dependent hypoacetylated hypomethylated...
DNA repeats, found at the ribosomal locus, telomeres and subtelomeric regions, are unstable sites of eukaryotic genomes. A fine balance between genetic variability genomic stability tunes plasticity these chromosomal regions. This tuning mechanism is particularly important for organisms such as microbial pathogens that utilise genome a strategy adaptation. For first time, we analyse mechanisms promoting rDNA locus regions in most common human fungal pathogen: Candida albicans In this...
Centromeres, sites of kinetochore assembly, are important for chromosome stability and integrity. Most eukaryotes have regional centromeres epigenetically specified by the presence histone H3 variant CENP-A. CENP-A chromatin is often surrounded pericentromeric regions packaged into transcriptionally silent heterochromatin. Candida albicans, most common human fungal pathogen, possesses small assembled chromatin. The state C. albicans unknown. Here, first time, we address this question. We...
Glioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal development are often dysregulated GBM. Among these, BMI1, a structural component of Polycomb Repressive Complex 1 (PRC1), which promotes H2AK119ub catalytic activity Ring1B, upregulated GBM its tumorigenic role has been shown vitro vivo. Here, we have used protein chromatin immunoprecipitation followed by mass spectrometry (MS) analysis to elucidate composition...
ABSTRACT Diverse microbial ecosystems underpin life in the sea. Among these microbes are many unicellular eukaryotes that span diversity of eukaryotic tree life. However, genetic tractability has been limited to a few species, which do not represent or environmentally relevant taxa. Here, we report on development tools range protists primarily from marine environments. We present evidence for foreign DNA delivery and expression 13 species never before transformed advancement 8 other as well...
<h3>Background</h3> Recent advances in immunotherapy have led to the development of multiple therapeutic modalities that harness T cells recognize and eliminate cancer cells, bringing benefit patients with unmet need. However, targeted immunotherapies utilized traditional tumor-associated antigens, which lack specificity broad expression across patient populations. We Enara Bio's EDAPT™ (Enara Dark Antigen Platform Technology) platform probe genomic dark matter (genomic regions previously...