Valentina Zemser-Werner
A5018300374- Advanced Radiotherapy Techniques
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Prostate Cancer Diagnosis and Treatment
- melanin and skin pigmentation
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Cutaneous Melanoma Detection and Management
- Diet and metabolism studies
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Amoebic Infections and Treatments
- Congenital gastrointestinal and neural anomalies
- Atherosclerosis and Cardiovascular Diseases
- Bladder and Urothelial Cancer Treatments
- Medicine and Dermatology Studies History
Tel Aviv Sourasky Medical Center
2019-2024
Despite the remarkable successes of cancer immunotherapies, majority patients will experience only partial response followed by relapse resistant tumors. While treatment resistance has frequently been attributed to clonal selection and immunoediting, comparisons paired primary relapsed tumors in melanoma breast cancers indicate that they share clones. Here, we demonstrate both mouse models clinical human samples tumor cells evade immunotherapy generating unique transient cell-in-cell...
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism behind this relationship remains mostly unknown. Here we report that exercise induces metabolic reprogramming of internal organs increases nutrient demand protects against metastatic colonization by limiting availability to tumor, generating an exercise-induced shield. Proteomic ex vivo capacity analyses murine revealed catabolic processes, glucose uptake, mitochondrial activity, GLUT expression. analysis...
Fat cells secrete cytokines that enhance pro-metastatic TGF-β signaling in melanoma cells.
Abstract Cutaneous melanoma tumors are heterogeneous and show diverse responses to treatment. Identification of robust molecular biomarkers for classifying into clinically distinct homogenous subtypes is crucial improving the diagnosis treatment disease. In this study, we present a classification four with different survival profiles based on three gene expression signatures: keratin, immune, melanogenesis. The melanogenesis pattern includes several genes that characteristic melanosome...
Medical education in pathology relies on the accumulation of experience gained through inspection numerous samples from each entity. Acquiring sufficient teaching material for rare diseases, such as Hirschsprung disease (HSCR), may be difficult, especially smaller institutes. The current study makes use a previously developed decision support system using algorithm meant to aid pathologists diagnosis HSCR.To assess effect short training session algorithm-assisted HSCR diagnosis.Five reviewed...
Abstract Background & objectives Tumor grade determines prognosis in urothelial carcinoma. The classification of low and high is based on nuclear morphological features that include size, hyperchromasia pleomorphism. These are subjectively assessed by the pathologists not numerically measured, which leads to rates interobserver variability. purpose this study assess value a computer-based image analysis tool for identifying predictors tumor bladder cancer. Methods Four hundred images...
Lupus erythematosus (LE) is an autoimmune disorder commonly affecting the skin; cutaneous lesions may indicate systemic involvement, warranting further evaluation. Photosensitivity, which result in hyperpigmentation, a well-known feature of disease. In contrast, prevalence primary hyperpigmentation as presenting sign LE not well established. Here, we compare 3 unique cases diffuse facial manifestation (cutaneous or systemic) and review previously reported cases. Our data highlight need for...
<div>Abstract<p>Exercise prevents cancer incidence and recurrence, yet the underlying mechanism behind this relationship remains mostly unknown. Here we report that exercise induces metabolic reprogramming of internal organs increases nutrient demand protects against metastatic colonization by limiting availability to tumor, generating an exercise-induced shield. Proteomic <i>ex vivo</i> capacity analyses murine revealed catabolic processes, glucose uptake,...
Supplementary Data from An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Supplementary Data from An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Supplementary Data from An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Supplementary Data from An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination