A5077741072- Antibiotic Resistance in Bacteria
- Plant Pathogenic Bacteria Studies
- Antibiotics Pharmacokinetics and Efficacy
- Trace Elements in Health
- melanin and skin pigmentation
- Glaucoma and retinal disorders
- Enterobacteriaceae and Cronobacter Research
- Enzyme Production and Characterization
- Reproductive tract infections research
- Bacterial Infections and Vaccines
- Tuberculosis Research and Epidemiology
- Ocular Diseases and Behçet’s Syndrome
- Cytomegalovirus and herpesvirus research
- Pharmaceutical and Antibiotic Environmental Impacts
- Viral-associated cancers and disorders
- Genomics and Phylogenetic Studies
Chulalongkorn University
2016-2018
The University of Queensland
2017
Siriraj Hospital
2012-2016
Mahidol University
2011-2016
Neisseria gonorrhoeae is a major public health problem globally, especially because the bacterium has developed resistance to most antimicrobials introduced for first-line treatment of gonorrhea. In present study, 96 N. isolates with high-level penicillin from 121 clinical in Thailand were examined investigate changes related their plasmid-mediated and molecular epidemiological relationships. A β-lactamase (TEM) gene variant, bla(TEM-135), that may be precursor transitional stage traditional...
ABSTRACT Carbapenem-resistant Enterobacteriaceae are urgent threats to global human health. These organisms produce β-lactamases with carbapenemase activity, such as the metallo-β-lactamase NDM-1, which is notable due its association mobile genetic elements and lack of a clinically useful inhibitor. Here we examined ability copper inhibit activity NDM-1 explored potential coordination complex mechanism efficiently deliver an adjuvant in clinical therapeutics. An NDM-positive Escherichia coli...
Behcet's Disease (BD) is a multisystem chronic inflammatory disease. The pathology believed to involve both genetic susceptibility and environmental factors. Hypomethylation leading activation of interspersed repetitive sequences (IRSs) such as LINE-1 Alu contributes the pathologies autoimmune diseases cancer. Herein, epigenetic changes IRSs in BD were evaluated using combined bisulfite restriction analysis-interspersed (COBRA-IRS). DNA from neutrophils peripheral blood mononuclear cells...
Background/Aims . Epigenetic mechanisms via DNA methylation may be related to glaucoma pathogenesis. This study aimed determine the global level of trabeculectomy specimens among patients with different types and normal subjects. Methods Trabeculectomy sections from 16 primary open-angle (POAG), 12 angle-closure (PACG), secondary patients, 10 controls were assessed for using combined-bisulfite restriction analysis. The percentage interspersed repetitive sequences LINE-1, Alu, HERV-E, HERV-K...
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Background: Carbapenem-resistant Enterobacteriaceae has become problematic recently worldwide. The first carbapenem-resistant Klebsiella pneumoniae from a provincial hospital near Bangkok, Pranangklao Hospital, Nonthaburi, Thailand, was isolated fatal case of 88 years old female patient. Identification resistant mechanism used by this isolate is very important for control and prevention possible spread organism or its gene(s) responsible carbapenem resistance. Methods: A sputum sample...
Background: Acinetobacter baumannii infection has become one of the most serious public health concerns due to its extensive resistances all classes antibiotics. Colistin was brought back battle against these multi-drug resistant A. as majority strains are still susceptible. However, colistin also gradually emerge. exerts action by binding negative-charged phosphate moieties lipid A, endotoxic component lipopolysaccharides. resistance in been linked alteration A structure, that is negative...