A5089876967- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- SARS-CoV-2 and COVID-19 Research
- Cervical Cancer and HPV Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Genital Health and Disease
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- Vaccine Coverage and Hesitancy
- Cancer Risks and Factors
- Pancreatic and Hepatic Oncology Research
- Advanced Breast Cancer Therapies
- Glioma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cancer survivorship and care
- Hematopoietic Stem Cell Transplantation
- CNS Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Telemedicine and Telehealth Implementation
- Global Cancer Incidence and Screening
- Renal cell carcinoma treatment
- Breast Implant and Reconstruction
Moffitt Cancer Center
2021-2025
University of South Florida
2022-2023
Oncology Nursing Society
2023
Post-transplantation cyclophosphamide (PTCy) is being increasingly used for graft-versus-host disease (GVHD) prophylaxis after allogeneic hematopoietic cell transplantation (allo-HCT) across various donor types. However, immune reconstitution and infection incidence PTCy-based versus conventional GVHD has not been well studied. We evaluated the density (ie, absolute CD4+ T cell, CD8+ natural killer B counts) at 3 months, 6 1 year post-HCT in 583 consecutive adult patients undergoing allo-HCT...
13 Background: Advanced penile cancer is a rare but aggressive malignancy. Over 70% of patients with bulky metastases relapse or have primary refractory disease current treatments. Immunotherapy represents promising modality, response rates remain low. While prior studies explored single immune factors within the tumor microenvironment (TME), understanding complex interactions between T cells and macrophages in relation to crucial best characterize TME. Methods: We performed multiplex...
12 Background: Previous studies utilizing multiplex Immunofluorescence (mIF) have described cell density patterns of immune exhaustion implicating both innate and adaptive system components across varying stages penile squamous carcinoma (PSCC). Here we studied geospatial clustering various effector cells within the tumor microenvironment (TIME). Methods: Tissue microarray (TMA) was constructed for 57 cases invasive PSCC immunostained CD20, CD3, CD4, CD8, CD45RO, CD68, CD206, CD163, NKp46,...
Patients with cancer experience high rates of morbidity and mortality after SARS-CoV-2 infection. Immune response to mRNA-1273 vaccination across multiple types treatments remains be established.To quantitate antibody responses among patients solid tumors hematologic assess clinical treatment factors associated vaccine response.This cohort study included who were aged 18 years or older, spoke English Spanish, had received their first dose between January 12 25, 2021, agreed blood tests...
Mismatch repair-deficient (MMR-D)/microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) is a unique disease entity with growing interest given the rise of young-onset CRC. Given its heterogeneous behavior and potential for highly effective treatment outcomes, we sought to identify clinical molecular features that offer prognostic value MMR-D
554 Background: The CM 214 trial with Nivolumab-ipilimumab recently presented its long term follow up results regards to efficacy and safety. In this abstract, we similarly present extended 6 year of efficacy, safety, correlative data from the phase 2 clinical combining IL-2 short course pembrolizumab (pembro) for patients (pts) metastatic renal cell carcinoma (mRCC). Methods: This study included pts untreated clear mRCC ECOG 0-1 status. Pts were treated a maximum four 9-week blocks...
Penile squamous cell carcinoma (PSCC) is a rare and deadly malignancy. Therapeutic advances have been stifled by poor understanding of disease biology. Specifically, the immune microenvironment an underexplored component in PSCC activity checkpoint inhibitors observed subset patients suggests escape may play important role tumorigenesis. Herein, we explored for first time 57 men with how it varies presence human papillomavirus (HPV) infection across tumor stages using multiplex...
Background The use of web-based methods to collect population-based health behavior data has burgeoned over the past two decades. Researchers have used platforms and research panels study a myriad topics. Data cleaning prior statistical analysis survey is an important step for integrity. However, processes by teams are often not reported. Objective objectives this manuscript describe systematic approach clean collected via platform from panelists share lessons learned with other promote...
To assess how the COVID-19 pandemic affected catch-up HPV vaccination among age-eligible adults (ages 18–45). The current study leverages a national, cross-sectional sample of US ages 18–45 years to prevalence and determinants pandemic-related disruptions in 2021. was restricted intending receive vaccine. Multinomial logistic regression analysis conducted probability 1) disruption 2) uncertainty about disruption. Report 'no disruption' served as reference category. Among get vaccine (n =...
Abstract Background The current study examined self‐reported human papillomavirus (HPV) vaccination uptake and intentions, associations with psychosocial constructs among United States adults aged 18 to 26 27 45 years. Methods Data were collected via an online survey from participants recruited a research panel. Outcomes HPV intentions. Multivariable binary ordered logistic regression models used examine between outcomes constructs, sociodemographics, previous health behaviors. Results in...
Leptomeningeal disease (LMD) is a devastating complication of systemic malignancy, which there an unclear etiology. The aim this study to determine if surgical or anatomic factors can predict LMD in patients with metastatic melanoma.A retrospective chart review was performed 1162 treated at single institution for melanoma brain metastases (MBM). Patients fewer than 3 months follow-up lacking appropriate imaging were excluded. Demographic information, surgical, and data collected.Eight...
Abstract Background Compared to the general population, cancer patients are at higher risk of morbidity and mortality following SARS‐CoV‐2 infection. The immune response a two‐dose regimen mRNA vaccines in is generally lower than immunocompetent individuals. Booster doses may meaningfully augment this population. We conducted an observational study with primary objective determining immunogenicity vaccine dose three (100 μg) mRNA‐1273 among secondary evaluating safety 14 28 days. Methods was...
Abstract Background Cigarette smoking is related to greater cancer incidence, worse cancer-related clinical outcomes, and patient quality of life. Few studies have evaluated the role in patients’ experiences symptom burden. This study examined relationships between total burden as well incidence severe symptoms among adult patients. Patients Methods at Moffitt Cancer Center completed self-report surveys part routine care. Symptom was sum individual ratings (total burden) number rated...
Background: There has been limited study of how the COVID-19 pandemic affected women's health care access. Our aims to examine prevalence and correlates COVID-19-related disruptions (1) primary care; (2) gynecologic (3) preventive among women. Materials Methods: We recruited 4,000 participants from a probability-based online panel. conducted four multinomial logistic regression models, one for each outcomes: access; patient-initiated visits; (4) provider-initiated visits. Results: The sample...
Axillary lymph node metastases are a key prognostic factor in breast cancer treatment. Our aim was to evaluate how tumor size, location, and imaging results correlate axillary diseases for patients with stage I-III HER2/neu+ cancer. This is single-institution retrospective chart review of female diagnosed primary invasive Her2/neu+ who were treated upfront surgical resection from 2000-2021. Of 75 cases, 44/75 (58.7%) had nodal metastasis, there significant association larger size (p ≤...
Background: Axillary node status is an important prognostic factor in breast cancer. The primary aim was to evaluate tumor size and other characteristics relative axillary disease. Materials Methods: Single institution retrospective chart review of stage I-III cancer patients collected demographic clinical/pathologic data from 1998–2019. Student’s t-test, Chi-squared test (or Fisher exact if applicable), logistic regression models were used for testing the association pN+ predictive...
Estimating the actual extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is challenging because virus test positivity data undercount number and proportion persons infected. SARS-CoV-2 seroprevalence a marker past infection regardless presence or severity symptoms therefore robust biomarker period prevalence. We estimated among residents Hillsborough County, Florida, USA, to determine factors independently associated with antibody status overall asymptomatic...
Abstract As oropharyngeal cancer (OPC) associated with human papillomavirus (HPV) increases in men, the need for a screening test to diagnose OPC early is crucial. While HPV‐associated has favorable prognosis, recurrence likely, and metastatic often incurable regardless of HPV status. Our previous study pretreatment, male cases ( n = 101) age‐ smoking‐matched controls found methylation host EPB41L3 tumor suppressor gene HPV16 oral gargle was correlated these biomarkers tumor. Methylation...
Physical function prior to allogeneic hematopoietic cell transplant (HCT) is associated with survival and may be patient physical activity (PA). Tools evaluate PA HCT are scarce. We aimed the impact of easily obtained patient-report on survival.HCT recipients between January 1, 2011 July 5, 2018 who completed an International Activity Questionnaire Short Form were included. This survey captures self-reported activities over preceding week determine level.We report a retrospective study 587...