A5013380374- Asthma and respiratory diseases
- Orbital Angular Momentum in Optics
- Advanced Fiber Laser Technologies
- Nonlinear Photonic Systems
- IL-33, ST2, and ILC Pathways
- Metamaterials and Metasurfaces Applications
- Mechanical and Optical Resonators
- Carcinogens and Genotoxicity Assessment
- Monetary Policy and Economic Impact
- Mosquito-borne diseases and control
- Market Dynamics and Volatility
- Air Quality and Health Impacts
- Advanced Antenna and Metasurface Technologies
- Dermatology and Skin Diseases
- Toxic Organic Pollutants Impact
- Nonlinear Waves and Solitons
- Photonic and Optical Devices
- Viral Infections and Vectors
- Advanced Fiber Optic Sensors
- Financial Risk and Volatility Modeling
- Nonlinear Dynamics and Pattern Formation
- Insect symbiosis and bacterial influences
- Liquid Crystal Research Advancements
- Optical Coatings and Gratings
- Eosinophilic Esophagitis
Guangdong Pharmaceutical University
2023-2024
Sun Yat-sen University
2007-2024
Guangzhou University
2011-2023
Shanghai University of Sport
2021
Guangdong Ocean University
2020
Sanofi (United States)
2016-2020
Peninsula Research
2018
National Institute for Health Research
2018
University of Oxford
2018
University of California, Los Angeles
2018
Dupilumab is a fully human anti–interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13 signaling. We assessed its efficacy safety in patients with uncontrolled asthma.
Airborne polycyclic aromatic hydrocarbons (PAH) are widespread urban air pollutants from fossil fuel burning and other combustion sources. We previously reported that a broad spectrum of combustion-related DNA adducts in cord blood was associated with attention problems at 6-7 years age the Columbia Center for Children's Environmental Health (CCCEH) longitudinal cohort study.We evaluated relationship between behavioral two different measures prenatal exposure--both specific to PAH--in same...
Abstract Introduction Dupilumab, a fully human anti-IL-4Rα monoclonal antibody, inhibits signaling of both interleukin (IL)-4 and IL-13, which are key drivers type 2-mediated inflammation. Dupilumab is approved in the EU, USA, other countries for treatment adults with inadequately controlled moderate-to-severe atopic dermatitis. Following positive phase 2 results asthma, 3 Liberty Asthma QUEST trial was initiated to provide further evidence dupilumab efficacy safety patients uncontrolled,...
Background: Airborne polycyclic aromatic hydrocarbons (PAH) are widespread urban pollutants that can bind to DNA form PAH–DNA adducts. Prenatal PAH exposure measured by personal monitoring has been linked cognitive deficits in childhood a prospective study conducted the Columbia Center for Children's Environmental Health.Objectives: We and other bulky adducts umbilical cord white blood cells using 32P-postlabeling assay determine association between this molecular dosimeter...
Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4 and interleukin-13, key drivers of type 2 inflammation. In phase 3 LIBERTY ASTHMA QUEST trial (NCT02414854) in patients with uncontrolled, moderate-to-severe asthma, add-on dupilumab 200 mg or 300 every weeks reduced exacerbations improved forced expiratory volume 1 s (FEV1) quality life over 52 weeks. This analysis evaluates dupilimab's effect on lung function overall population, subgroups...
Zika virus (ZIKV), belonging to the Flavivirus family and mainly transmitted by mosquitoes, causes a variety of adverse outcomes, including Guillain-Barré syndrome, microcephaly, meningoencephalitis. However, there are no approved vaccines or drugs available for ZIKV. The discovery research on ZIKV still essential. In this study, we identified doramectin, an veterinary antiparasitic drug, as novel anti-ZIKV agent (EC50 value from 0.85 μM 3.00 μM) with low cytotoxicity (CC50 > 50 in...
Agarwood essential oil (AEO) holds significant medicinal and economic value. While its antitumor activity is reported in the literature, active ingredients remain unexplored. In this study, chemical composition of AEO extracted by steam distillation (SD) fungal fermentation-assisted SD (FFSD) was evaluated gas chromatography-mass spectrometry (GC-MS). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Subsequently, key targets were using grey relational analysis...
The major severe complications linked to Zika virus (ZIKV) cause the global public health problems, including microcephaly and other congenital abnormalities in newborns, Guillain-Barré syndrome, meningoencephalitis, multi-organ failure adults. However, neither approved vaccines nor drugs are available for ZIKV. In this study, we describe design, synthesis anti-ZIKV activities of a series anthraquinone analogs. Most newly synthesized compounds demonstrated moderate excellent potency against...
The Zika virus (ZIKV) is a mosquito-borne that already poses danger to worldwide human health. Patients infected with ZIKV generally have mild symptoms like low-grade fever and joint pain. However, severe can also occur, such as Guillain-Barré syndrome, neuropathy, myelitis. Pregnant women may cause microcephaly in newborns. To date, we still lack conventional antiviral drugs treat infections. Marine natural products novel structures diverse biological activities. They been discovered...
<b>Introduction:</b> In a pivotal phase 2b trial (NCT01854047), adult patients (pts) with uncontrolled persistent asthma using ICS+LABA were randomized to 24 weeks (wks) of add-on therapy dupilumab (DPL; an anti-IL-4Rα antibody), 200 or 300 mg every 2 (q2w) q4w, placebo (PBO). DPL significantly reduced the rate severe exacerbation when administered q2w. Most common adverse events (DPL vs PBO) upper respiratory tract infections (12−15% 18%) and injection site erythema (8−22% 8%). We aimed...
Ascomylactam C (AsC) is a new 13-membered-ring macrocyclic alkaloid, which was first isolated and identified in 2019 from the secondary metabolites of mangrove endophytic fungus Didymella sp. CYSK-4 South China Sea. AsC has been found to have broad-spectrum cytotoxic activity. However, antitumor effects vivo mechanisms remain unclear. The aim this study describe on lung cancer melanoma cells explore molecular mechanism AsC. In vitro, we used plate colony formation experiments demonstrated...
Polycyclic aromatic hydrocarbons (PAH) are a class of chemicals common in the environment. Certain PAH carcinogenic, although degree to which genetic variation influences susceptibility carcinogenic remains unclear. Also unknown is influence on procarcinogenic effect utero exposures PAH. Benzo[a]pyrene (B[a]P) well-studied that classified as probable human carcinogen. Within our New York City-based cohort, we explored interactions between maternal exposure airborne during pregnancy and...
Metasurfaces are usually planar structures and do not possess intrinsic chirality therefore hardly generate optical activity. Here we realized a tunable activity in terahertz wave through microfluid-based soft metasurface. The meta-atom is chiral structured microchannel made of polydimethylsiloxane injected with the liquid metal Galinstan. A microfluid pressure system bonded to metasurface reconfigure all meta-atoms simultaneously. By pumping glycerol into system, deformed from structure...
<b>Background:</b> Dupilumab (DPL), a fully human anti-IL-4Rα mAb that inhibits IL-4/IL-13, is approved for treatment of adults with inadequately controlled moderate-to-severe atopic dermatitis. In phase 3 study (NCT02414854), asthma patients (pts) aged ≥12 years, no minimum baseline (BL) eosinophil requirement, uncontrolled medium-to-high-dose ICS, plus 1 or 2 controllers received DPL 200/300mg placebo (PBO) every weeks 52 weeks. reduced severe exacerbations, improved FEV1 and quality life...
We propose a precision measurement method of laser linewidth based on short-delay self-homodyne, using the second peak-valley difference (SPVD) feature coherent power spectrum to fit linewidth. The SPVD model self-homodyne envelope was established. One-to-one correspondence among values SPVD, delay length, and determined theoretically through simulations, while reliability stability verified experimentally. By comparing detected results, it is found that fitted obtained by system closer its...