A5019108467- Cardiac Structural Anomalies and Repair
- Anesthesia and Sedative Agents
- Aortic Disease and Treatment Approaches
- Tissue Engineering and Regenerative Medicine
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- EEG and Brain-Computer Interfaces
- Intensive Care Unit Cognitive Disorders
- Electrospun Nanofibers in Biomedical Applications
- Transplantation: Methods and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Issues in Pregnancy
- Pancreatitis Pathology and Treatment
- Cardiac Arrhythmias and Treatments
- Epilepsy research and treatment
- Pancreatic function and diabetes
- Treatment of Major Depression
- Liver Disease and Transplantation
- Bipolar Disorder and Treatment
- Cardiac Arrest and Resuscitation
- Mesenchymal stem cell research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Effects of Exercise
- Cardiac Fibrosis and Remodeling
- Pancreatic and Hepatic Oncology Research
University of Helsinki
2014-2024
Helsinki University Hospital
2014-2024
Peijas Hospital
2014
Tampere University
2009
Acute liver failure (ALF) and hepatic encephalopathy (HE) can lead to an elevated intracranial pressure (ICP) death within days. The impaired function increases the risks of invasive ICP monitoring, whereas noninvasive methods remain inadequate. purpose our study was explore reliable neuromonitoring for patients with ALF in intensive care unit (ICU) setting; more specifically, we wanted track changes HE predict outcomes treated albumin dialysis. included 20 severe at admission who had been...
Background: Cardio-regenerative cell therapies offer additional biologic support to coronary artery bypass surgery (CABG) and are aimed at functionally repairing the myocardium that suffers from or is damaged by ischemia. This non-randomized open-label study assessed safety feasibility of epicardial transplantation atrial appendage micrografts (AAMs) in patients undergoing CABG surgery. Methods: Twelve consecutive destined for were included study. Six received AAMs during their operation six...
Abstract Background Assessing nociception and sedation in mechanically ventilated patients the ICU is challenging, with few reliable methods available for continuous monitoring. Measurable cardiovascular neurophysiological signals, such as frontal EEG, EMG, heart rate, blood pressure, have potential The hypothesis of this explorative study that derived variables from aforementioned signals predict level sedation, described by Richmond Agitation-Sedation score (RASS), respond to painful...
Hypothermic circulatory arrest carries a high risk of mortality and neurological complications. An important part assessing surgical treatment is the evaluation long-term survival postoperative health-related quality life.In this prospective study, 30 patients undergoing hypothermic during surgery thoracic aorta, 31 comparison elective coronary artery without were evaluated for life, using RAND 36-Item Health Survey questionnaire. The results compared to national age- sex-matched reference...
Bone marrow mononuclear cells (BMMCs) have been evaluated for their ability to improve cardiac repair and benefit patients with severe ischemic heart disease failure. In our single-center trial in 2006-2011 we demonstrated the safety efficacy of BMMCs injected intramyocardially conjunction coronary artery bypass surgery. The effect persisted follow-up study 5 years later. this study, investigated BMMC therapy beyond 10 years. A total 18 (46%) died during over 10-years 21 were contacted...
<title>Abstract</title> <italic><bold>Background</bold></italic><italic>—</italic>The AAMS open-label clinical study demonstrated safety and feasibility of epicardial transplantation autologous right atrial appendage micrografts (AAMs) during coronary artery bypass grafting (CABG) surgery. Delivered in an extracellular matrix patch, the also provided first indications reduced ischemic scar increased live ventricular wall thickness associated with AAMs therapy. To further evaluate initial...
Background and Aims: Circulatory arrest carries a high risk of neurological damage, but modern monitoring methods lack reliability, is susceptible to the generalized effects both anesthesia hypothermia. The objective this prospective, explorative study was research promising, reliable, noninvasive neuromonitoring, capable predicting outcome after hypothermic circulatory arrest. Materials Methods: Thirty patients undergoing during surgery thoracic aorta were recruited in single center over...
The concentrations of several diagnostic markers have been found to increase dramatically in critically ill patients with a severe disturbance normal physiological homeostasis, without indication the diseases they are normally associated with. To prevent false diagnoses and inappropriate treatments patients, it is important that aiding selection second-line evaluated such not only healthy population levels trypsinogen isoenzymes, trypsin inhibitor serine peptidase Kazal type 1 (SPINK1), hCG...
Objectives. To compare long-term angina pectoris relief of successful versus failed percutaneous coronary intervention chronic total occlusions (CTO PCI). Background. Previous studies demonstrate better short-term CTO PCI than with optimal medical treatment (OMT), however, data on the effects are lacking. Methods. 295 patients undergoing were analyzed retrospectively, a follow-up evaluation symptoms and all-cause death one to four years after intervention. The primary outcome was pectoris....
Abstract Objectives Cardio-regenerative cell therapies offer additional biologic support to coronary artery bypass surgery (CABG) for treating the myocardium suffering from or damaged by ischemia. This phase 1, open-label study assessed safety and feasibility of epicardial transplantation atrial appendage micrografts (AAMs) in patients undergoing CABG surgery. Methods Twelve consecutive destined were included study. Six received AAMs during their operation six CABG-operated without...
Abstract Background: Assessing nociception and sedation in mechanically ventilated patients the ICU is challenging, with few reliable methods available for continuous monitoring. Measurable cardiovascular neurophysiological variables, such as frontal EEG, EMG, blood pressure, are potential The hypothesis of this explorative study that aforementioned variables predict level sedation, described by Richmond Agitation-Sedation score (RASS). Methods: Thirty adult postoperative on mechanical...