A5002260629- Infectious Encephalopathies and Encephalitis
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Polyomavirus and related diseases
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Pharmacological Effects and Toxicity Studies
- Bacillus and Francisella bacterial research
- Autoimmune Neurological Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience of respiration and sleep
- Prion Diseases and Protein Misfolding
- Bacterial Infections and Vaccines
- Breastfeeding Practices and Influences
- Cytomegalovirus and herpesvirus research
- Systemic Sclerosis and Related Diseases
- Nerve injury and regeneration
- Extracellular vesicles in disease
- Congenital heart defects research
- Multiple Sclerosis Research Studies
- Mitochondrial Function and Pathology
- Congenital gastrointestinal and neural anomalies
- Hereditary Neurological Disorders
- Ion Transport and Channel Regulation
- Protein Kinase Regulation and GTPase Signaling
Shinshu University
2006-2023
Nagano Children's Hospital
2014-2023
Shinshu University Hospital
2023
National Epilepsy Center
2015-2018
Abstract Background In rare cases, patients with Langerhans cell histiocytosis (LCH) develop neurodegenerative CNS disease (ND‐CNS‐LCH). Management of ND‐CNS‐LCH has not been established. Methods We treated five pediatric a combination intravenous immunoglobulin (IVIG) and chemotherapy (steroid ± vinblastine 6‐mercaptopurine methotrexate). Prior to the therapy, three had cerebellar ataxia while remaining two abnormal MRI findings without apparent neurological deficits. IVIG was given monthly...
Abstract Fulminant W ilson's disease ( WD ) is life‐threatening. The revised prognostic index RWPI has been used to predict the severity of disease, with a score ≥11 indicating fatal outcome without liver transplantation LTx ). We here report case 10‐year‐old female patient fulminant , 16) who recovered fully after plasma exchange and continuous hemodiafiltration, followed by treatment copper chelate agents. To best our knowledge, there have five patients ≥ 11 including present patient, in...
To elucidate the genetic background and genotype-phenotype correlations for epilepsy with myoclonic-atonic seizures, also known as myoclonic-astatic (MAE) or Doose syndrome.
An encephalocele is a pathological brain herniation caused by osseous dural defects. Encephaloceles are known to be regions of epileptogenic foci. We describe the case 44-year-old woman with refractory epilepsy associated frontal skull base encephalocele. Epilepsy surgery for resection was performed; however, refractory. A second lobectomy using intraoperative electroencephalography required achieve adequate seizure control. Previous reports have shown that only can result in good control,...
Abstract Functional roles of the perioral anatomical structures involved in breastfeeding were examined newborn rat pups which hypoglossal (XII) and facial (VII) nerves had been resected at neonatal stage. The XII nerve controls tongue movement is comprised two functionally distinct branches: medial branch related to protrusion lateral its retraction. Newborn with bilateral resection either components (main trunk: XII‐trunk; branch: XII‐med; XII‐lat) failed suckle milk did not survive....
A nine-yr-old girl developed AdV-associated HC after bone marrow transplantation. Intravenous GCV markedly reduced urinary AdV DNA loads and improved clinical findings. This appeared to result partly from a high concentration of in urine. may be effective for AdV-induced without definitive disseminated infection.
Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA) (OMIM #617481) is an autosomal recessive disease characterized by progressive plagiocephaly, spastic quadriparesis, global developmental delay, intellectual disability, optic features abnormal magnetic resonance imaging (MRI). NMIHBA was recently reported to be caused PRUNE1 mutations. Eight mutations have been in 13 unrelated families. Here, we report 3 1 Caucasian Japanese One recurrent missense...
ABSTRACT We report a six‐year‐old girl with seizures induced by both micturition and defecation. Several days after unprovoked generalised tonic‐clonic seizures, she developed reflex characterised the extension of arms rhythmic jerking her upper body. No abnormal findings were noted on brain magnetic resonance imaging. Interictal electroencephalography (EEG) showed spike‐and‐wave activity central electrode recording, fast was recorded electrodes during ictal EEG upon micturition. The...
We report a pediatric case of critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis during acute lymphoblastic leukemia therapy. A 15-year-old boy developed B. multiple organ failure on the 19th day after initiation chemotherapy, multidisciplinary treatment was started. Treatment effective septic shock with remitted. He weaned from respirator 23 onset sepsis, but complete flaccid paralysis 4 extremities occurred. His compound muscle action potential F-wave occurrence...
Abstract The hypoglossal (XII) nerve is made up of functionally different branches: the medial branch related to protrusion tongue and lateral its retraction. present study was performed determine effects facial (VII) XII injuries on survival growth rats in which unilateral or bilateral VII components (main trunk, XII‐trunk; branch, XII‐med; XII‐lat) had been resected at developmental stages. In suckling period, as well XII‐trunk XII‐med produced disturbed milk intake, lower rates...
The present study was aimed to determine neuronal population essential for normal motor function in young adult rats receiving various degrees of crushing the sciatic nerve at neonatal stage. Motor estimated by static index, and a tracer applied common peroneal nerve. total numbers tracer-labeled neurons nerve-crushed were 74–383 group, 14–61 disordered 0–32 severely group. We conclude that can be well preserved very small (approximately 15% control value) neonatally nerve-injured rats.
Abstract We report a case of multiple organ failure caused by the Bacillus cereus infection during acute lymphoblastic leukemia therapy, who was treated successfully. A 15‐year‐old male developed ( B. ) sepsis on 19th day after chemotherapy initiation. Polymyxin‐direct hemoperfusion for septic shock started, followed continuous hemodiafiltration. His condition improved starting hemoperfusion. At onset sepsis, elevated levels serum inflammatory cytokines, anti‐inflammatory and...
Abstract Functional role of lingual nerve in breastfeeding was investigated rat pups during the suckling period. DiI, a postmortem neuronal tracer, used to confirm immature (LN) responsible for tongue sensation and resulted successful fiber labeling anterogradely tongue, which showed different distribution patterns from derived hypoglossal nerve. Unilaterally LN‐injured did not show disturbance with absence any shortening (P11 pups: 559 ± 16 s; 105% control value) nipple attachment time...