A5102748106- Advanced X-ray Imaging Techniques
- Nuclear Physics and Applications
- Electron and X-Ray Spectroscopy Techniques
- Medical Imaging Techniques and Applications
- Advancements in Photolithography Techniques
- Atomic and Subatomic Physics Research
- Radiomics and Machine Learning in Medical Imaging
- Non-Destructive Testing Techniques
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Trace Elements in Health
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Lysosomal Storage Disorders Research
- Radiation Detection and Scintillator Technologies
- Virus-based gene therapy research
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Quantum, superfluid, helium dynamics
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders
- Electronic and Structural Properties of Oxides
Argonne National Laboratory
2022-2024
Shanghai Jiao Tong University
2023
University College London
2019-2022
Jinan University
2019-2022
Southern University of Science and Technology
2021-2022
Second Affiliated Hospital of Xi'an Jiaotong University
2022
Second Affiliated Hospital of Zhejiang University
2020
National Institute for Materials Science
2016-2019
University of Tsukuba
2016-2019
Zhejiang University
2017
Hereditary hemochromatosis (HH) is a common autosomal recessive disease characterized by increased iron absorption and progressive storage that results in damage to major organs the body. Recently, candidate gene for HH called HFE encoding histocompatibility complex class I-like protein was identified positional cloning. Nearly 90% of Caucasian patients have been found be homozygous same mutation (C282Y) gene. To test hypothesis involved regulation homeostasis, we studied effects targeted...
γδT cells have been reported to exert immunosuppressive functions in multiple solid malignant diseases, but their functional subpopulation breast cancer (BC) is still undetermined. Here, we collected 40 paired BC and normal tissue samples from Chinese patients for analysis. First, showed that γδT1 comprise the majority of CD3+ T BC; next, found CD73+γδT1 were predominant regulatory T-cell (Treg) population BC, prevalence peripheral blood was also related tumour burden. In addition, an effect...
Hereditary hemochromatosis (HH) is a common autosomal recessive disorder characterized by tissue iron deposition secondary to excessive dietary absorption. We recently reported that HFE, the protein defective in HH, was physically associated with transferrin receptor (TfR) duodenal crypt cells and proposed mutations HFE attenuate uptake of transferrin-bound from plasma cells, leading up-regulation transporters for iron. Here, we tested hypothesis −/− mice have increased expression divalent...
Circular RNAs (circRNAs) have been reported to regulate the incidence of tumor by regulating transcriptional level and post-transcriptional tumor-related genes, are significantly correlated with metastasis progression. CircRNA_100395 (circ_100395) has suppress lung cancer cell proliferation, might act as an oncogene in deveopment various cancers. However, expression function circ_100395 ovarian not systematically researched.
Adoptive cell therapy using TCR-engineered T cells (TCR-T cells) represents a promising strategy for treating relapsed and metastatic cancers. We previously established methods to identify neoantigen-specific TCRs based on patients' PBMCs. However, in clinical practice isolation of PBMCs from advanced-stage cancer patients proves be difficult. In this study, we substituted blood-derived tumor-infiltrating lymphocytes (TILs) used an HLA-matched line antigen-presenting (APCs) replace...
β-Glucuronidase (GUSB) is a lysosomal enzyme important in the normal step-wise degradation of glycosaminoglycans. Deficiency GUSB causes storage disease mucopolysaccharidosis VII (MPS VII, Sly disease). Affected patients have widespread progressive accumulation β-glucuronide-containing glycosaminoglycans lysosomes. Enzyme replacement, bone marrow transplantation, and gene therapy can correct MPS mouse model. Gene animals may result massive overexpression individual tissues, toxicity such...
Mucopolysaccharidosis type VII (MPS VII; Sly syndrome) is an autosomal recessive lysosomal storage disorder due to inherited deficiency of beta-glucuronidase. A naturally occurring mouse model for this disease was discovered at The Jackson Laboratory and shown be homozygosity a 1-bp deletion in exon 10 the gus gene. murine MPS (gus(mps/mps)) has been very well characterized used extensively evaluate experimental strategies diseases, including bone marrow transplantation, enzyme replacement...
A 23-year-old Caucasian man diagnosed with stage IVB Hodgkin's disease was referred to a university oncology section after completing 1.5 cycles of chemotherapy. His chemotherapy consisted doxorubicin HCL, bleomycin, dacarbazine, and vinblastine, prophylactic administration granulocyte colony stimulating factor. He had developed postchemotherapy complications possible cellulitis necrotizing fasciitis that required wound debridement. The tissue cultures were negative. Biopsies taken at the...
For many years, it has been believed that self-organized periodic ring structures known by the name of Liesegang patterns (LPs) are formed only in quite thick media, typically thicker than at least several micrometers. Actually growing LPs ultrathin films is extremely difficult because drying film and susceptibility to rapid capillary wetting. The present work reports how we obtain successful 65 nm thick. key parameters temperature control introduction equilibrium water vapor sample...
Abstract Adoptive transfer of T cell receptor (TCR)‐engineered cells targeting viral epitopes represents a promising approach for treating virus‐related cancers. However, the efficient identification and corresponding TCR remains challenging. Here, we report workflow permitting rapid generation human papillomavirus (HPV)‐specific TCR‐T cells. Six proteins belonged to HPV16 or HPV18 were predicted have high affinity A11:01 according bioinformatic analysis. Subsequently, CTL induction...
Recently, the authors have succeeded in realizing X-ray reflectivity imaging of heterogeneous ultrathin films at specific wavevector transfers by applying a wide parallel beam and an area detector. By combining in-plane angle grazing-incidence scans, it is possible to reconstruct series interface-sensitive images different angles (proportional transfers). The physical meaning reconstructed image transfer two-dimensional distribution sample. In this manner, retrieve micro-X-ray (where pixel...
X-ray reflectivity is a promising technique for characterizing buried layers and interfaces in ultrathin films because of its ability to probe the electron density profile along depth non-destructive manner. While routine assumes in-plane uniformity sample be measured, it also quite important see inhomogeneous/patterned interfaces. The present paper describes addition spatial resolution imaging capability an visualize surfaces To wide viewing area size quickly, image reconstruction scheme...
The aim of this study is to examine gestational serum thyroid hormone levels and influencing factors among Chinese pregnant women with high dietary iodine intake.The was conducted from 2011 2013 in Zhoushan Women & Children's Hospital, Zhejiang, China. A total 1991 were enrolled their free hormones (FT4, FT3, TSH) detected by chemiluminescence method.Gestational FT4 FT3 decreased week while TSH increased. Furthermore, the prevalence rate subclinical hypothyroid increased stages, especially...
When designing some functions in thin film systems, one of the key concepts is structure constituent layers and interfaces. In an actual system, interfaces are often inhomogeneous different scales, from hundreds microns to several nanometers, causing differences properties, despite very similar average structures. this case, choice observation point critical clarify problem. Another aspect identification these points by surveying entire system. This article presents a description novel...
X-ray reflectivity is usually used for the routine analysis of layered structures uniform thin films. So far, technique has some limitations in application to more practical inhomogeneous/patterned samples. imaging recently developed and can give reconstructed image from many reflection projections. The present article gives instrumental details compact imager. Though power source only 15 W, it works well. calibration system been discussed, because particularly important grazing incidence...
With histopathology results typically taking several days, the ability to stage tumors during interventions could provide a step change in various cancer interventions. X-ray technology has advanced significantly recent years with introduction of phase-based imaging methods. These have been adapted for use standard labs rather than specialized facilities such as synchrotrons, and approaches that enable fast 3D scans conventional x-ray sources developed. This opens possibility produce images...
Exotic functions of thin films are quite often connected to the unique atomic and molecular features buried layers interfaces. In reality, structures far from uniform, but seeing such inhomogeneity is extremely difficult. The present research concerns how solve difficulty. novel technique developed X-ray reflectivity imaging. While ordinary gives very precise information on electron density profile along depth in films, method can have some imaging capability, by combining with image...
A 13-year-old girl came to the emergency room with abdominal pain that had begun 24 hours earlier following trauma upper abdomen during a soccer game. The became progressive and was accompanied by nausea vomiting. Her past medical history remarkable only for several episodes of vomiting 2 years. These were self-limited resolved spontaneously without intervention. Physical examination revealed palpable tender mass in right quadrant epigastric area abdomen. Ultrasound computed tomography scan...
Abstract In endometriosis, an aberrant immune response in the peritoneal environment is evident, but underlying mechanism remains unclear. recent years, some emerging data support important role for changes intracellular metabolic pathways of cells controlling their function. this study, we aim to investigate phenotypic and immunometabolism profiling fluid endometriosis patients. By flow cytometry, our results show with higher percentages CD45 + , CD3 CD8 CD56 +, CD14 CD68 ratio M2 M1...
<h3>Introduction</h3> Oesophageal cancer is the 5th commonest cause of death in UK. It accounts for 9,000 new cases every year. Most oesophageal cancers are diagnosed at a late stage. Survival data shows that patients with early disease have 37.5% 5 year survival compared to 8.4% and 4.9% those regional or distant disease.<sup>1</sup> Histological diagnosis pathology an expensive time consuming process high inter observer variability. X-ray imaging inexpensive has not previously been used...
X-ray Phase-Contrast Computed Tomography (PC-CT) increases contrast in weakly attenuating samples, such as soft tissues. In Edge-Illumination (EI) PC-CT, phase effects are accessed from amplitude modulation of the x-ray beam using alternating transmitting and masks placed prior to sample detector. A large field view PC-CT scanner this technique was applied two areas cancer assessment, namely excised breast esophageal tissue. For tissue, Wide Local Excisions (WLEs) were studied...