A5028132251- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Whipple's Disease and Interleukins
- Epigenetics and DNA Methylation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Complement system in diseases
- Reproductive System and Pregnancy
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- NF-κB Signaling Pathways
- Immunodeficiency and Autoimmune Disorders
- Dermatology and Skin Diseases
- Chromatin Remodeling and Cancer
- Gene Regulatory Network Analysis
- Urticaria and Related Conditions
- Gut microbiota and health
- Research on Leishmaniasis Studies
- Genomics and Chromatin Dynamics
The University of Melbourne
2016-2024
Peter Doherty Institute
2018-2024
California Institute of Technology
2021-2024
Walter and Eliza Hall Institute of Medical Research
2013-2021
Burnet Institute
2012
MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These develop intrathymically through three-stage process, but events that regulate this are largely unknown. Here, using bulk and single-cell RNA sequencing-based transcriptomic analysis mice humans, we studied changing transcriptional landscape accompanies transition each stage. Many transcripts were sharply modulated during MAIT cell development, including SLAM (signaling lymphocytic...
Abstract Differentiation and homeostasis of Foxp3 + regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; however, molecular mechanisms that govern these processes incompletely understood. Here we show Bach2 is an important regulator Treg cell differentiation downstream TCR signaling. prevents premature fully suppressive effector (eTreg) cells, limits IL-10 production required for the development peripherally induced (pTreg) in gastrointestinal tract. attenuates...
Despite the key role that antibodies play in protection, cellular processes mediating acquisition of humoral immunity against malaria are not fully understood. Using an infection model severe malaria, we find germinal center (GC) B cells upregulate transcription factor T-bet during infection. Molecular and analyses reveal is required only for IgG2c switching but also favors commitment to dark zone GC. was found regulate expression Rgs13 CXCR3, both which contribute impaired GC polarization...
BCL11B is a transcription factor with six C 2 H -type zinc-finger domains. Studies in mice have shown that Bcl11b plays essential roles T cell development. Several germline heterozygous variants been identified human patients inborn errors of immunity (IEI) patients. Among these, two de novo mis-sense cause asparagine (N) to lysine (K) replacement distinct domains, N441K and N807K . To elucidate the pathogenesis variant, we generated mouse model by inserting corresponding mutation, N797K ,...
BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) is a transcription factor best known for its role in B cell development. More recently, it has been associated with T functions inflammatory diseases, proposed as master transcriptional regulator within the compartment. In this study, we employed cell-specific Bach2-deficient (B6.Bach2ΔT) mice to examine of CD4+ vitro infected Plasmodium chabaudi AS. We found that under polarising conditions vitro, Th2 Th17 helper...
Abstract The differentiation of regulatory T (Treg) cells is strictly controlled by cell receptor (TCR) signals. However, the downstream regulators this process are incompletely understood. Here we have found that Bach2 blocks genomic binding TCR-induced transcription factor IRF4, attenuating TCR-dependent transcriptional programs to fine-tune Treg development and differentiation. In absence observed an increase in TCR-driven outcomes, including enhanced effector thymic precursor cells, a...