A5030439285- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Congenital Ear and Nasal Anomalies
- T-cell and B-cell Immunology
- Vascular Anomalies and Treatments
- Autoimmune Bullous Skin Diseases
- Otitis Media and Relapsing Polychondritis
- Infectious Diseases and Mycology
- Extracellular vesicles in disease
- Fungal Infections and Studies
- Neutropenia and Cancer Infections
- Advances in Oncology and Radiotherapy
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders
- Platelet Disorders and Treatments
- Global Health and Surgery
- Inflammatory Myopathies and Dermatomyositis
- Parkinson's Disease and Spinal Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
- Advanced Radiotherapy Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Prostate Cancer Treatment and Research
University of Utah
2022-2024
American Academy of Dermatology
2022
University of California, San Francisco
2019-2020
Duke University
2016-2019
Partners In Health
2018
Harvard University
2018
Brigham and Women's Hospital
2018
Dana-Farber Cancer Institute
2011-2012
Efficacy of dendritic cell (DC) cancer vaccines is classically thought to depend on their antigen-presenting (APC) activity. Studies show, however, that DC vaccine priming cytotoxic T lymphocytes (CTLs) requires the activity endogenous DCs, suggesting exogenous DCs stimulate antitumor immunity by transferring antigens (Ags) DCs. Such Ag transfer functions are most commonly ascribed monocytes, implying undifferentiated monocytes would function equally well as a modality and need not be...
Small-molecule biased agonists of a chemokine receptor elicit distinct physiological outcomes.
Low- and middle-income countries disproportionately comprise 65% of cancer deaths. Cancer care delivery in resource-limited settings, especially low-income sub-Saharan Africa, is exceedingly complex, requiring multiple modalities diagnosis treatment. Given the vast human, technical, financial resources required, access to radiotherapy remains limited Africa. Through 2017, Rwanda has not had in-country services. The aim this study was describe implementation early outcomes referral program at...
Undifferentiated monocytes can be loaded with tumor antigens (Ag) and administered intravenously to induce antitumor cytotoxic T lymphocyte (CTL) responses. This vaccination strategy exploits an endogenous Ag cross-presentation pathway, where Ag-loaded (monocyte vaccines) transfer their resident splenic dendritic cells (DC), which then stimulate robust CD8 + CTL In this study, we investigated whether monocyte in combination CDX-301, a DC-expanding cytokine Fms-like tyrosine kinase 3 ligand...
A promising area of investigation in AML is the development cancer vaccines that educate host immunity to target leukemia cells, including stem cell compartment. Our group has developed a vaccine which dendritic cells (DCs) are fused autologous tumor resulting presentation multiple antigens and eliciting broad immune response. challenge developing more effective overcoming inhibitory pathways, PD1/PDL1 pathway, contributing tumor-mediated suppression. We conducting clinical trial patients...
e18023 Background: Medical oncology patients have high rates of unplanned hospital admissions. The characteristics these admissions and the medical needs this patient population not been clearly defined. cost cancer care is rising with much that incurred in last 6 months life during acute inpatient care. aim study was to define main clinical relevant admitted our service. Methods: We performed a retrospective analysis solid tumor service at Duke University Hospital from 1/1/2012 – 6/30/2012....
Abstract Dendritic cells (DC) have been key elements in developing effective cancer vaccines to induce potent anti-tumor immunity. However, the common approach adopted clinical trials using ex vivo generated DC loaded with tumor antigens (Ag) has challenged by its limited response, complexity, and quality of manufacturing process. Alternative efforts focused on Ag loading endogenous DCs not yet well validated their efficacy for treatment, suggesting efficiency transfer from Ag-carrying...
Abstract Conventional dendritic cell (DC) vaccines using ex vivo generated DC have been widely tested in clinical trials the treatment of human cancers. These often displayed limited efficacy despite a complex manufacturing process. Although is generally thought to depend on their antigen-presenting function, several lines evidence suggest that, instead directly presenting antigen (Ag) naïve T cells, administered trigger cytotoxic lymphocyte (CTL) responses mainly by transferring Ag...
A 45-year-old man from Tonga was noted to have thick, scaly skin on both feet. He reported a 20-year history of painful calluses and fissures the soles, as well nail thickening intermittent white patches in oral cavity. On physical examination, there yellow-colored hyperkeratotic scale projecting plantar aspects feet (Fig 1), hypertrophic dystrophy, wedge-shaped subungual hyperkeratosis 2).Fig 2View Large Image Figure ViewerDownload Hi-res image Download (PPT) Question 1: Which following...