A5078393366- Streptococcal Infections and Treatments
- Pancreatic function and diabetes
- Retinoids in leukemia and cellular processes
- Infective Endocarditis Diagnosis and Management
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Antioxidant Activity and Oxidative Stress
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Plant Pathogenic Bacteria Studies
- Diet and metabolism studies
- Animal Disease Management and Epidemiology
- Neonatal and Maternal Infections
- Gut microbiota and health
- RNA and protein synthesis mechanisms
- Vibrio bacteria research studies
- Escherichia coli research studies
- Endoplasmic Reticulum Stress and Disease
- Acute Ischemic Stroke Management
- RNA Research and Splicing
- Pancreatitis Pathology and Treatment
- Vitamin C and Antioxidants Research
- Stroke Rehabilitation and Recovery
Nanjing University
2019-2024
Nanjing General Hospital of Nanjing Military Command
2020-2024
PLA Army Engineering University
2019
First People's Hospital of Foshan
2018-2019
Nanjing Agricultural University
2012-2013
Xiaomi (China)
2010
Background: Vitamin A (VA) plays an essential role in pancreatic homeostasis.Islet stellate cells (ISCs) are VA-storing islets.Herein, we have investigated the effect of VA on glucose homeostasis trough regulation ISCs function dietary deficiency model mice.Methods: Male C57BL/6 mice were randomly fed a VA-sufficient, VA-deficient (VAD) or VAD-rescued diet.Glucose metabolism was assessed by tolerance tests and immunohistochemistry. activation degree evaluated immunofluorescence, quantitative...
Aims We evaluated the efficacy and significant changes in levels of retinol-binding protein 4 (RBP-4) insulin resistance patients with type 2 diabetes mellitus (T2DM) treated chiglitazar versus sitagliptin. Methods Eighty-one T2DM haemoglobin A1c (HbA1c) level 7.5%–10.0% were selected. Based on study criteria, randomly assigned to receive (32 mg), (48 or sitagliptin (100 mg) orally for 24 weeks. Sociodemographic anthropometric characteristics, lipid profiles, glucose serum RBP-4 determined...
Aims . The underlying mechanisms involved in Vitamin A- (VA-) related changes glucose metabolic disorders remain unclear. Recent evidence suggests that intestinal microbiota is closely linked to the syndrome. Here, we explored whether and how affects homeostasis VA-deficient diet-fed mice. Methods Six-week-old male C57BL/6 mice were randomly placed on either a VA-sufficient (VAS) or (VAD) diet for 10 weeks. Subsequently, subclass of VAD was switched rescued (VADR) an additional 8 phenotypes...
The small intestine serves as the first channel of dietary Vitamin A (VA) and unique organ VA absorption metabolism. However, there have not been extensive investigations on exact mechanisms within VA-related changes in intestinal metabolic disorders. This research is designed to analyze whether how affects phenotypes. Male C57BL/6 mice after weaning were randomly fed a control diet (VAC) or VA-deficient (VAD) during entire pregnancy lactation process. After total 11 weeks, cohorts deprived...
We explored whether and how perilipin 2 (Plin2) protected islets against lipotoxicity-induced islet dysfunction by regulating stellate cells (ISCs) activation.Six-week-old male rats were given a high-fat diet or control for 28 weeks. Glucose metabolic phenotypes assessed using glucose/insulin tolerance tests, masson, immunohistochemical staining. ISCs activation levels from palmitic acid- (PA-) treated cultured immunofluorescence, Oil red O staining, electron microscopy, quantitative PCR,...
Objective To compare the predictive value of 10 prehospital assessment scales for large vessel occlusion in patients with acute ischemic stroke. Methods From January 2016 to December 2018, stroke within 24 h onset admitted Department Neurology, Nanfang Hospital, Southern Medical University were enrolled retrospectively. The scores various calculated based on clinical data, including National Institutes Health Stroke Scale (NIHSS), Los Angeles Motor (LAMS), and 3-item scale (3I- SS),...
Regnase-1 is an newly recognized endonuclease that plays a critical role on transcriptional regulation and immunity homeostasis.It can be rapidly induced under diverse microenvironmental stimulus functionally terminated by multiple mechanisms.Regnase-1 destabilize set of mRNAs, which encode many inflammatory cytokines, to elicit anti-inflammation function participate in physiological pathological processes.Regnase-1 important negative regulator its tightly controlled level necessary maintain...