A5013964408- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Neural Networks and Applications
- Global Security and Public Health
- Advanced Fluorescence Microscopy Techniques
- Health and Conflict Studies
- Image Processing and 3D Reconstruction
- Advanced Optical Sensing Technologies
- Cell Image Analysis Techniques
- Optical Imaging and Spectroscopy Techniques
- Memory and Neural Mechanisms
- Migration, Health and Trauma
- CCD and CMOS Imaging Sensors
- Medical Imaging Techniques and Applications
- Dental Radiography and Imaging
- Neural and Behavioral Psychology Studies
Humboldt-Universität zu Berlin
2020-2024
Charité - Universitätsmedizin Berlin
2017-2023
Humboldt State University
2021
Hebrew University of Jerusalem
2007-2015
Institute of Life Sciences
2010
The active electrical properties of dendrites shape neuronal input and output are fundamental to brain function. However, our knowledge has been almost entirely acquired from studies rodents. In this work, we investigated the layer 2 3 (L2/3) pyramidal neurons human cerebral cortex ex vivo. these neurons, discovered a class calcium-mediated dendritic action potentials (dCaAPs) whose waveform effects on have not previously described. contrast typical all-or-none potentials, dCaAPs were...
We present a novel framework for automatically constraining parameters of compartmental models neurons, given large set experimentally measured responses these neurons. In experiments, intrinsic noise gives rise to variability (e.g., in firing pattern) the voltage repetitions exact same input. Thus, common approach fitting by attempting perfectly replicate, point point, single chosen trace out spectrum variable does not seem do justice data. addition, finding error function that faithfully...
Understanding the neurobiological mechanisms underlying consciousness remains a significant challenge. Recent evidence suggests that coupling between distal–apical and basal–somatic dendrites in thick-tufted layer 5 pyramidal neurons (L5 PN ), regulated by nonspecific-projecting thalamus, is crucial for consciousness. Yet, it uncertain whether this thalamocortical mechanism can support emergent signatures of consciousness, such as integrated information. To address question, we constructed...
Using computational tools we explored the impact of local synaptic inhibition on plasticity excitatory synapses in dendrites. The latter critically depends intracellular concentration calcium, which turn, membrane potential and thus inhibitory activity particular dendritic compartments. We systematically characterized dependence morphology, loci strength, as well spatial distribution level activity. Plasticity may attain three states: "protected" (unchanged), potentiated (long-term...
The electrical and computational properties of neurons in our brains are determined by a rich repertoire membrane-spanning ion channels elaborate dendritic trees. However, the precise reason for this inherent complexity remains unknown, given that simpler models with fewer also able to functionally reproduce behaviour some neurons. Here, we stochastically varied channel densities biophysically detailed dentate gyrus granule cell model produce large population putative cells, comparing those...
This computational study integrates anatomical and physiological data to assess the functional role of lateral excitatory connections between layer 2/3 (L2/3) pyramidal cells (PCs) in shaping their response during early stages intracortical processing a whisker deflection (WD). Based on vivo vitro recordings, 3D reconstructions connected pairs L2/3 PCs, our model predicts that: 1) AMPAR NMDAR conductances/synapse are 0.52 ± 0.24 0.40 0.34 nS, respectively; 2) following WD, connection PCs...
Rapid advances in neuroscience have provided remarkable breakthroughs understanding the brain on many fronts. Although promising, role of these advancements solving problem consciousness is still unclear. Based technologies conceivably within grasp modern neuroscience, we discuss a thought experiment which neural activity, form action potentials, initially recorded from all neurons participant’s during conscious experience and then played back into same neurons. We consider whether this...
Abstract The burst coding hypothesis posits that the occurrence of sudden high-frequency patterns action potentials constitutes a salient syllable neural code. Many neurons, however, do not produce clearly demarcated bursts, an observation invoked to rule out pervasiveness this scheme across brain areas and cell types. Here we ask how detrimental ambiguous spike patterns, those are neither bursts nor isolated spikes, for neuronal information transfer. We addressed question using theory...
High-speed volumetric imaging is crucial for observing fast and distributed processes such as neuronal activity. Multiphoton microscopy helps to mitigate scattering effects inside tissue, but the standard raster scanning approach limits achievable volume rates. Random access point can lead a considerable speed-up by sampling only pre-selected locations, existing techniques based on acousto-optic deflectors are still limited rate of up . This number parallel targets at high acquisition rates...
Neocortical layer 5 (L5) pyramidal cells have at least two spike initiation zones: Na + spikes are generated near the soma, and Ca 2+ apical dendritic tuft. These interact with each other serve as signals for synaptic plasticity. The present computational study explores implications of having spike-timing-dependent plasticity (STDP) in a neuron, its respective regional population “pupils.” In detailed model an L5 competition emerges between synapses belonging to different regions, on top...
We explored in a computational study the effect of dendrites on excitatory synapses undergoing spike-timing-dependent plasticity (STDP), using both cylindrical dendritic models and reconstructed trees. show that even if initial strength, g(peak), distal is augmented location independent manner, efficacy diminishes following STDP proximal would eventually dominate. Indeed, always win over linear rule, synaptic strength distribution tree. This more pronounced as cable length increases but it...
Abstract The electrical and computational properties of neurons in our brains are determined by a rich repertoire membrane-spanning ion channels elaborate dendritic trees. However, the precise reason for this inherent complexity remains unknown. Here, we generated large stochastic populations biophysically realistic hippocampal granule cell models comparing those with all 15 to their reduced but functional counterparts containing only 5 channels. Strikingly, valid parameter combinations full...
Neocortical layer 5 (L5) pyramidal cells have at least two spike initiation zones: Na(+) spikes are generated near the soma, and Ca(2+) apical dendritic tuft. These interact with each other serve as signals for synaptic plasticity. The present computational study explores implications of having spike-timing-dependent plasticity (STDP) in a neuron, its respective regional population "pupils." In detailed model an L5 competition emerges between synapses belonging to different regions, on top...
Abstract High-speed volumetric imaging is crucial for observing fast and distributed processes such as neuronal activity. Multiphoton microscopy helps to mitigate scattering effects inside tissue, but the standard raster scanning approach limits achievable volume rates. Random-access can lead a considerable speed-up by sampling only pre-selected locations, existing techniques based on acousto-optic deflectors are still limited point rate of up ∼50 kHz. This number parallel targets at high...
The Blue Brain Project is an attempt to reverse-engineer and model the neocortical column, explore how it functions serve as a tool for neuroscientists medical researchers. In order achieve goal of automatically fitting models latest data from clearly defined sources, series calibration steps have been developed. Each step includes physiological database, analysis technique comparison data. All scored completeness quality. aspects which implemented are: volume composition ion channels,...
Rapid advances in neuroscience have provided remarkable breakthroughs understanding the brain on many fronts. Although promising, role of these advancements solving problem consciousness is still unclear. Based technologies conceivably within grasp modern neuroscience, we envision an experiment where action potentials are initially recorded from all neurons a subject’s during conscious experience and then played back into same neurons. We examine whether this artificial replay can...
“The Coverage Problem” is a class of optimization problems used in different fields that aims to explore the best strategy order maximally “cover” region under some constrains. For example, how could limited number cellular antennas be distributed such their signals would cover maximal (e.g., whole city) while limiting radio-frequency radiation safe levels? Here we ask whether notion coverage applied inhibitory synapses, giving them optimal control over excitatory/excitable activity...