A5101966899- Advanced MRI Techniques and Applications
- Cytokine Signaling Pathways and Interactions
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Wnt/β-catenin signaling in development and cancer
- Intracranial Aneurysms: Treatment and Complications
- Liver Disease Diagnosis and Treatment
- Garlic and Onion Studies
- Ultrasound and Hyperthermia Applications
- Chemotherapy-induced organ toxicity mitigation
- Parathyroid Disorders and Treatments
- Cancer Treatment and Pharmacology
- Ultrasound Imaging and Elastography
- Medical Imaging and Pathology Studies
- Cardiac Imaging and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Neurosurgical Procedures and Complications
- Autoimmune and Inflammatory Disorders Research
- Peptidase Inhibition and Analysis
- Blood Coagulation and Thrombosis Mechanisms
- MRI in cancer diagnosis
- Infectious Aortic and Vascular Conditions
- Otitis Media and Relapsing Polychondritis
- Connective tissue disorders research
China-Japan Friendship Hospital
2015-2025
Ministry of Ecology and Environment
2024
Chengde Medical University
2013-2023
Soochow University
2014-2023
The First People's Hospital of Changzhou
2019
Affiliated Hospital of Chengde Medical College
2019
Jingzhou Central Hospital
2014
Hebei Medical University
2011
Second Hospital of Hebei Medical University
2011
Fudan University
2011
Introduction: Diabetic kidney disease (DKD) necessitates innovative therapeutic strategies. This study delves into the role of DNA damage-inducing transcription factor 4 (DDIT4) within VDR-mTOR pathway, aiming to identify a novel target for DKD drug discovery. Methods: Transcriptome data from Gene Expression Omnibus Database were analyzed assess expression mTOR and VDR in human renal tissues. Clinical samples patients minimal change (MCD) controls examined, animal model using 20-week-old...
<title>Abstract</title> Purpose This study aims to evaluate the causal relationship between chronic kidney disease (CKD) and osteoporosis using two-sample Mendelian randomization (MR) drug-target MR, investigate potential association TNFRSF11A estimated glomerular filtration rate (eGFR). Methods The utilized single nucleotide polymorphisms (SNPs) associated with eGFR urinary albumin-to-creatinine ratio (UACR) identified by Chronic Kidney Disease Genetics Consortium, as well SNPs related...
Background: Secondary hyperparathyroidism (SHPT) is a frequently encountered problem in patients with end-stage renal disease (ESRD). Some severe SHPT could not be managed by medical treatment and are ineligible for surgical resection.Purpose: Our objective was to evaluate the efficacy, safety of microwave ablation (MWA) on these patients.Materials Methods: Between 1 April 2015 28 February 2017, 35 (M/F 19/16, age 49.8 ± 12.9 years) were enrolled. All treated MWA. Levels intact parathyroid...
Mild cognitive impairment (MCI) occurs frequently in many end stage renal disease (ESRD) patients, may significantly worsen survival odds and prognosis. However, the exact neuropathological mechanisms of MCI combined with ESRD are not fully clear. This study examined functional connectivity (FC) alterations default-mode network (DMN) individuals MCI.Twenty-four identified as patients were included this study; these, 19 5 underwent hemodialysis (HD) peritoneal dialysis (PD), respectively....
Malignant melanoma is a highly metastatic cancer, and has poor prognosis once metastasis occurred. E-cadherin downregulation associated with poorer in various types of including lung, ovarian, cervical prostate. In the majority cancer cell lines, upregulation inhibits motility, migration invasiveness, reduces tumor vivo models. present study, inhibitory effects metformin on invasion B16F10 murine line, possible molecular mechanisms underlying this effect were investigated. cells treated...
Background: End-stage renal disease (ESRD) patients often have cognitive dysfunction. The abnormal changes in the brains of ESRD are difficult to detect with routine imaging examination. Cognitive performance scales also not an ideal tool because assessments using these can be subjective and might administer some patients. Functional magnetic resonance has advantages non-radiation, multidirectional imaging, good repeatability. Using resting-state functional (rs-fMRI) amplitude low-frequency...
Several epidemiological surveys of allergic rhinitis (AR) have been conducted in China. However, the clinical features AR are still not clear enough. The aim current study was to perform a multicenter investigation evaluate China.A performed 13 allergy centers central A disease-related questionnaire completed by each patient themselves or with guardian assistance after diagnosis AR. and allergen profile were analyzed.Eleven thousand four patients who diagnosed recruited this study....
2',4'‑dihydroxy‑6'‑methoxychalcone (cardamonin) is a natural compound with anti‑proliferative effects on several cancer types including nasopharyngeal carcinoma. The of cardamonin melanoma cells are unknown. present study investigated the effect human cell lines (M14 and A375), underlying apoptosis inducing mechanisms. MTS assay showed that inhibited M14 viability, reduction density was also observed. Flow cytometry induced in dose‑dependent manner. Western blot analysis protein expression...
Melanoma is one of the most deadly skin cancers. T-cadherin an atypical member cadherin superfamily as it lacks transmembrane and cytoplasmic domains anchored to cell membranes through glycosylphosphatidylinositol (GPI) anchors. downregulation associated with a poorer prognosis in various carcinomas, such lung, ovarian, cervical prostate cancer, while majority cancer lines, re-expression inhibits proliferation invasiveness, increases susceptibility apoptosis reduces tumor growth vivo models....
Objective: To investigate the value of quantitative and semiquantitative parameters DCE-MRI in predicting IDH gene mutation high-grade gliomas before operation. Methods: Twenty-six individuals with surgically pathologically proved WHO Ⅲ-Ⅳ collected from April 2016 to June 2019 First People's Hospital Changzhou, were divided into two groups, group (7 cases, 27-67 years, 3 males 4 females,) wild (19 42-75 12 7 females) according results molecular pathology. All underwent conventional plain...
It is of great importance to predict the early recurrence (ER) hepatocellular carcinoma (HCC) after hepatectomy using preoperative imaging modalities. Nevertheless, no comparative studies have been conducted determine which modality, CT or MRI with radiomics analysis, more effective.We retrospectively enrolled 119 HCC patients who underwent and MRI. A total 3776 features 4720 were extracted from whole tumor. The minimum redundancy maximum relevance algorithm (MRMR) least absolute shrinkage...