A5081536186- Bone health and treatments
- Oral microbiology and periodontitis research
- Dental Implant Techniques and Outcomes
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Oral and gingival health research
- Dental materials and restorations
- Bone Tumor Diagnosis and Treatments
- Inflammatory mediators and NSAID effects
- Salivary Gland Disorders and Functions
- Cancer Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Fibroblast Growth Factor Research
- Cytokine Signaling Pathways and Interactions
- Oral and Maxillofacial Pathology
- Oral Health Pathology and Treatment
- Osteomyelitis and Bone Disorders Research
- dental development and anomalies
- Advanced Glycation End Products research
- Endodontics and Root Canal Treatments
- Bone and Dental Protein Studies
University of California, Los Angeles
2016-2025
Universidade Federal do Rio Grande do Norte
2018-2020
National and Kapodistrian University of Athens
2017
In-Q-Tel
2015
University of Michigan
2008-2010
Michigan United
2010
Aim To evaluate the effects of metformin (Met) on inflammation, oxidative stress, and bone loss in a rat model ligature-induced periodontitis. Materials & methods Male albino Wistar rats were divided randomly into five groups twenty-one each, given following treatments for 10 days: (1) no ligature + water, (2) (3) 50 mg/kg Met, (4) 100 (5) 200 Met. Water or Met was administered orally. Maxillae fixed scanned using Micro-computed Tomography (μCT) to quantitate linear volume/tissue volume...
Abstract Hyperlipidemia increases the risk for generation of lipid oxidation products, which accumulate in subendothelial spaces vasculature and bone. Atherogenic high-fat diets increase serum levels oxidized lipids, are known to attenuate osteogenesis culture promote bone loss mice. In this study, we investigated whether lipids affect regeneration mechanical strength. Wild-type (WT) hyperlipidemic (Ldlr−/−) mice were placed on a (HF) diet 13 weeks. Bilateral cranial defects introduced each...
Osteonecrosis of the jaw (ONJ) is a well-recognized complication antiresorptive medications, such as bisphosphonates (BPs). Although ONJ most common after tooth extractions in patients receiving high-dose BPs, many do not experience oral trauma. Animal models using and high BP doses recapitulate several clinical, radiographic, histologic findings ONJ. We others have reported on rat experimental dental disease absence extraction. These emphasize importance infection/inflammation for...
Antiresorptive medications are essential in treating diseases of pathologic osteoclastic bone resorption, including cancer and osteoporosis. Bisphosphonates (BPs) the most commonly used antiresorptives clinical practice. Although inhibition resorption is important regulating unwanted malignant metabolic osteolysis, BP treatment associated with potential side effects, osteonecrosis jaws (ONJ). Recently, non-BP antiresorptive targeting function differentiation, such as denosumab, have entered...
Abstract Aim Peri‐implantitis ( PI ), inflammation around dental implants, shares characteristics with periodontitis PD ). However, is more difficult to control and treat, detailed pathophysiology unclear. We aimed compare progression utilizing a murine model. Materials Methods Four‐week‐old male C57 BL /6J mice had their left maxillary molars extracted. Implants were placed in healed extraction sockets osseointegrated. Ligatures tied the implants second molars. Controls did not receive...
ABSTRACT Osteonecrosis of the jaws (ONJ) is a significant complication antiresorptive medications, such as bisphosphonates and denosumab. Antiresorptive discontinuation to promote healing ONJ lesions remains highly controversial understudied. Here, we investigated whether alters features in mice, employing potent bisphosphonate zoledronic acid (ZA) or receptor activator NF-κB ligand (RANKL) inhibitor OPG-Fc, utilizing previously published animal models. Mice were treated with vehicle (veh),...
Osteonecrosis of the jaws (ONJ) is a rare but severe complication antiresorptive medications, such as bisphosphonates, used in treatment bone malignancy or osteoporosis. Tooth extraction and dental disease have been strongly associated with ONJ development. Here, we investigated molecular cellular markers socket healing after healthy teeth experimental periodontitis (EP) Wistar-Han rats treated zoledronic acid (ZA). We included 4 groups: vehicle-treated animals ligature-induced EP ZA-treated...
Evidence shows that metformin is an antidiabetic drug, which can exert favorable anti-inflammatory effects and decreased bone loss. The development of nanoparticles for might be useful increased therapeutic efficacy. aim this study was to evaluate the effect hydrochloride-loaded Poly (d,l-Lactide-co-glycolide) (PLGA)/(MET-loaded PLGA) on a ligature-induced periodontitis model in diabetic rats. MET-loaded PLGA were characterized by mean diameter, particle size, polydispensity index,...
A high-fat (HF) diet inducing hyperlipidemia has been associated with the pathophysiology of major diseases, such as atherosclerosis and osteoporosis. HF significant adverse effects on bone, including lower bone density, volume, strength. Statins, drugs that serum cholesterol levels have beneficial metabolism. Since host's quantity, quality, healing potential play a crucial role in osseointegration dental implants, we hypothesized may negatively affect implant osseointegration. In present...
ABSTRACT Rheumatoid arthritis (RA), an autoimmune inflammatory disorder, results in persistent synovitis with severe bone and cartilage destruction. Bisphosphonates (BPs) are often utilized RA patients to reduce destruction manage osteoporosis. However, BPs, especially at high doses, associated osteonecrosis of the jaw (ONJ). Here, utilizing previously published ONJ animal models, we exploring interactions between incidence severity. DBA1/J mice were divided into four groups: control,...
Objective The aim of this study was to evaluate the effects gliclazide on oxidative stress, inflammation, and bone loss in an experimental periodontal disease model. Material Methods Male albino Wistar rats were divided into no ligature, ligature with 1, 5, 10 mg/kg groups. Maxillae fixed scanned using micro-computed tomography quantify linear volume/tissue volume (BV/TV) volumetric loss. Histopathological, immunohistochemical immunofluorescence analyses conducted examine matrix...