A5032368306- Molecular Biology Techniques and Applications
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Mycobacterium research and diagnosis
- Mass Spectrometry Techniques and Applications
- Essential Oils and Antimicrobial Activity
- Viral-associated cancers and disorders
- Virus-based gene therapy research
- Gene expression and cancer classification
- Ethnobotanical and Medicinal Plants Studies
- Medicinal Plants and Neuroprotection
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Quinazolinone synthesis and applications
- Ion-surface interactions and analysis
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
Beth Israel Deaconess Medical Center
2024-2025
University of Freiburg
2024
University of Ghana
2017-2019
Mycobacterium tuberculosis is a pathogen of global public health concern. This threat exacerbated by the emergence multidrug-resistant and extremely-drug-resistant strains pathogen. We have obtained two distinct clones smegmatis after gradual exposure mc2 155 to increasing concentrations erythromycin. The resulting resistant exhibited robust viability in presence high erythromycin were found be wide range other antimicrobials. They also displayed unique growth phenotype comparison parental...
Classic Hodgkin Lymphoma (cHL) is a tumor composed of rare malignant and Reed-Sternberg (HRS) cells nested within T-cell rich inflammatory immune infiltrate. cHL associated with Epstein-Barr Virus (EBV) in 25% cases. The specific contributions EBV to the pathogenesis remain largely unknown, part due technical barriers dissecting microenvironment (TME) high detail. Herein, we applied multiplexed ion beam imaging (MIBI) spatial pro-teomics on 6 EBV-positive 14 EBV-negative samples. We identify...
The advent of spatial transcriptomics and proteomics have enabled profound insights into tissue organization to provide systems-level understanding diseases. Both technologies currently remain largely independent, emerging same slide multi-omics approaches are generally limited in plex, resolution, analytical approaches. We introduce IN-situ DEtailed Phenotyping To High-resolution (IN-DEPTH), a streamlined resource-effective approach compatible with various platforms. This iterative first...
Extracts of Desmodium adscendens (Sw) DC are used for the treatment various diseases but limited toxicological evaluations have been done on medicinal plant. This study investigates toxicity effects leave extract D adscendens, and possibility drug-drug interaction plant when co-administered with other drugs. Oral administrations leaf to white Wistar rats in an acute studies allowed estimation LD 50 (median lethal dose) value 1122 mg/kg body weight. In a subchronic studies, caused decrease...
The early transcription unit 3 (E3) of human adenoviruses (HAdVs) encodes several immunoevasins, including the E3/49K protein, which is unique for species D HAdVs. It expressed as surface transmembrane protein and shed. HAdV-D64 binds to tyrosine phosphatase receptor CD45, thereby modulating activation T NK cells.