A5091464185- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Pediatric Urology and Nephrology Studies
- Infant Development and Preterm Care
- Cerebral Palsy and Movement Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital Diaphragmatic Hernia Studies
- Traumatic Brain Injury Research
- Radiation Dose and Imaging
- Tracheal and airway disorders
- Neuroscience of respiration and sleep
- Urological Disorders and Treatments
- Urinary Tract Infections Management
- Hip disorders and treatments
- Tumors and Oncological Cases
- Gastrointestinal disorders and treatments
- Congenital Heart Disease Studies
- Cardiac Arrest and Resuscitation
- Vascular Malformations and Hemangiomas
- Liver Disease Diagnosis and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Radiology practices and education
- Ultrasound in Clinical Applications
- Musculoskeletal synovial abnormalities and treatments
- Kidney Stones and Urolithiasis Treatments
Monash Medical Centre
2011-2025
Monash University
2014-2025
Monash Health
2014-2025
Monash Children’s Hospital
2014-2025
Clinical Trials New Zealand
2021
Society of Surgical Oncology
2019
Burke Medical Research Institute
2018
Murdoch Children's Research Institute
2007-2016
CSIRO Manufacturing
2016
Australian Regenerative Medicine Institute
2015
<h3>Objective:</h3> Higher latitude, lower ultraviolet exposure, and serum 25-hydroxyvitamin D (25OHD) correlate with higher multiple sclerosis (MS) prevalence, relapse rate, mortality. We therefore evaluated the effects of high-dose vitamin D2 (D2) in MS. <h3>Methods:</h3> Adults clinically active relapsing-remitting MS (RRMS) were randomized to 6 months9 double-blind placebo-controlled D2, 6,000 IU capsules, dose adjusted empirically aiming for a 25OHD 130–175 nM. All received daily...
Cranial CT scans are at the center of decision making in brain injuries children because their speed and ability to detect surgically relevant lesions. However, alternative techniques, such as conventional MRI may have advantages terms radiation exposure sensitivity injury. Susceptibility-weighted imaging (SWI), a relatively novel sequence, shows promise its detecting hemorrhagic lesions; however, clinical potential remains uncertain. In this observational study (5–16 years age) with...
DWI reportedly accurately differentiates pediatric posterior fossa tumors, but anecdotal experience suggests limitations. In 3 years, medulloblastoma and JPA were differentiated by alone in 23/26 cases (88%). Ependymoma (n = 5) could not be reliably from or JPA. A trend toward increased diffusion restriction higher grade tumors (1/14 I, 7%; 9/12 IV, 75%) had too much overlap to predict the of individual cases. The ADC between tumor types appeared partly due technical factors (in small,...
The purpose of this study was to investigate the frequency and spectrum magnetic resonance imaging (MRI) abnormalities in a population children with cerebral palsy (CP) who were born years 2000 2001 Victoria, Australia. In 2001, 221 (126 males, 95 females; mean age 6y [SD 7mo], range 5–7y) CP, excluding those CP due postneonatal causes (6% all cases), identified through Victorian Cerebral Palsy Register. All medical records systematically reviewed available brain comprehensively evaluated by...
Abstract Traumatic brain injury (TBI) in children results damage to the developing brain, particularly severely injured individuals. Little is known, however, of long‐term structural aspects following childhood TBI. This study investigated integrity 10 years post‐TBI using magnetic resonance imaging volumetrics a sample 49 participants with mild, moderate and severe TBI, evaluated against normative 20 individuals from pediatric database comparable age gender distribution. Structural was gray...
Perinatal asphyxia is a significant cause of death or long-term neurodevelopmental impairment. Hypothermia, currently the only effective treatment, leads to modest improvements, but new therapeutic strategies are required. Umbilical cord blood (UCB) mononuclear cells have potent anti-inflammatory properties and may reduce neuropathology. This study examined whether autologous UCB were neuroprotective when administered newborn lambs at 12 h after birth asphyxia. At caesarean section, was...
To review the authors' 15-year experience with bronchial artery embolization (BAE) for treatment of hemoptysis in young patients cystic fibrosis.By searching 1985-1999 radiology database, authors identified 23 who had been referred to department angiography. Twenty these underwent BAE. The medical records were retrospectively reviewed regard agents used, success rates, number repeat embolizations, survival times, and causes death.BAE was performed on 38 occasions 20 patients. mean age at...
Risk factors in the development of early renal cortical defects children with urinary tract infection.M R Ditchfield, J F de Campo, T M Nolan, D Cook, K Grimwood, H Powell, Sloane and S CahillAudio Available | Share
Abstract Childhood and adolescence are critical periods for maturation of neurobiological processes that underlie complex social emotional behavior including Theory Mind (ToM). While structural correlates ToM well described in adults, less is known about the anatomical regions subsuming these skills developing brain or impact cerebral insult on acquisition establishment high‐level cognitive skills. This study aimed to examine differential influence age‐at‐insult pathology a sample children...
Abstract Perinatal asphyxia remains a principal cause of infant mortality and long‐term neurological morbidity, particularly in low‐resource countries. No neuroprotective interventions are currently available. Melatonin ( MLT ), potent antioxidant, anti‐inflammatory antiapoptotic agent, offers promise as an intravenous IV ) or transdermal therapy to protect the brain. We aimed determine effect melatonin patch) on neuropathology lamb model perinatal asphyxia. Asphyxia was induced newborn...
In a population cohort of children with grey matter injury (GMI) and cerebral palsy (CP), we aimed to describe classify magnetic resonance imaging characteristics specific GMI, identify key structure-function associations that serve as basis for rating GMI in clinically relevant ways.Symmetry, extent injury, pathological pattern 54 (37 males, 17 females) CP predominant on chronic-phase were related gross motor function, type topography, epilepsy, intellectual disability, blindness,...
Specialist assessment and management is required for children who are considered at high risk of serious illness (underlying structural urinary tract abnormalities or neurogenic bladder kidney transplant recipients). These beyond the scope these guidelines, it important that they excluded from recommendations detailed below. UTI in common, about 6% girls 2% boys will experience an episode before their 7th birthday.1 Having had one infection, child a 13−19% having another UTI.2-4 causes pain,...