A5086231127- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Inflammatory mediators and NSAID effects
- Advanced SAR Imaging Techniques
- Extracellular vesicles in disease
- RNA modifications and cancer
- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic and Acetabular Injuries
- Mitochondrial Function and Pathology
- Electromagnetic Compatibility and Measurements
- NF-κB Signaling Pathways
- Proteoglycans and glycosaminoglycans research
- Growth Hormone and Insulin-like Growth Factors
- Electromagnetic Scattering and Analysis
- Periodontal Regeneration and Treatments
- Chemokine receptors and signaling
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- ATP Synthase and ATPases Research
- Cell Adhesion Molecules Research
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
- Radar Systems and Signal Processing
Nanjing Medical University
2020-2024
Jiangsu Province Hospital
2020-2024
Beijing Institute of Technology
2022-2024
Osteoarthritis (OA) is a prevalent degenerative joint disease that not only significantly impairs the quality of life middle-aged and elderly individuals but also imposes significant financial burden on patients society. Due to their biological properties, extracellular vesicles (EVs) have steadily received great attention in OA treatment. This study aimed investigate influence EVs chondrocyte proliferation, migration, apoptosis protective efficacy against mice.
Abstract Background Osteoarthritis (OA) is a common degenerative disease involving articular cartilage, in which ferroptosis of chondrocytes plays an important role. Baicalin (BAI) exerts regulatory effects wide range orthopedic diseases including OA, but its effect on (CHs) still unclear. The purpose this study was to determine the BAI human OA (OACs), and explore possible mechanism. Methods CHs were treated with IL-1β (10 ng/mL) simulate inflammation vitro. Immunofluorescence, quantitative...
Osteoarthritis (OA) is one of the most prevalent and degenerative diseases with complicated pathology including articular cartilage degradation, subchondral sclerosis synovitis. Chondrocytes play a crucial role in maintaining integrity.Primary chondrocytes were treated 10 ng/mL IL-1β alone, or pre-treated 20 μM baicalin for 5 h followed by co-treatment IL-1β. CCK-8 assay was used to assess cell viability, apoptosis analyzed both PI/FITC-Annexin V staining quantitating apoptosis-related...
Osteosarcoma is the most prevalent bone cancer that affects young adults and adolescents. It frequent malignancy of bone. In spite fact complete surgical resection chemotherapy have increased overall survival osteosarcoma patients considerably, prognosis remains dismal in with recurring and/or metastasized osteosarcoma. Thus, finding predictive biomarkers representing osteosarcoma's biological variability may result more effective treatment for patients.In this research, RNA data clinical...
Objective To explore the clinical efficacy of intramedullary reduction techniques for irreducible intertrochanteric femoral fractures with negative medial cortical support. Methods A retrospective analysis was conducted on 69 patients support treated in Department Orthopedics at Jiangsu Province Hospital (The First Affiliated Nanjing Medical University) from July 2019 to December 2021. Patients were divided into Group and B. (experimental group) consisted 36 cases an average age 76.2 ± 5.9...
Chondrocyte degeneration and classically activated macrophage (AM)-related inflammation play critical roles in osteoarthritis (OA). Here, we explored the effects of astaxanthin Rspo2 on OA vitro vivo. We observed that gene was markedly elevated synovial tissues patients compared with healthy controls. In 2D cultures, inflammatory factors were enhanced AMs nonactivated macrophages (NMs), protein expression levels Rspo2, β-catenin, increased, anabolic markers reduced osteoarthritic...
The osteoarthritis caused by trauma or inflammation is associated with severe patient morbidity and economic burden. Accumulating studies are focusing on the repair of articular cartilage defects constructing tissue-engineered cartilage. Recent evidence suggests that optimizing source quality seed cells one key points tissue engineering. In this study, we demonstrated Kindlin-2 its activated PI3K/AKT signaling played an essential role in promoting extracellular matrix (ECM) secretion...
This study explores the clinical efficacy of intra-articular injection chitosan combined with low-dose glucocorticoid for treatment knee osteoarthritis in early and middle stages. The visual analog scale (VAS) score, Lysholm Hospital Special Surgery (HSS) changes levels inflammatory cytokines IL-1, IL-6, TNF-α joint fluid before after 3 groups were compared, was evaluated. All cases followed up, a follow-up time 7 to 12 months, no lost cases. horizontal comparison showed that VAS HSS each...
The long non-coding RNA CRNDE (CRNDE) has been identified as a lncRNA associated with osteoarthritis (OA), playing role the age-related degeneration of articular cartilage. However, precise mechanism by which affects physiological functions OA chondrocytes remains unclear. To simulate inflammatory conditions observed in OA, interleukin (IL)-1β-stimulated chondrocyte C-28/I2 cells were utilized. expression levels and miR-31 assessed using reverse transcription-polymerase chain reaction...
Accumulating evidence indicates that cellular senescence is closely associated with osteoarthritis. However, there limited research on the mechanisms underlying fibroblast-like synoviocyte and its impact osteoarthritis progression. Here, we elucidate a positive correlation between progression reveal GATD3A deficiency induces senescence. Mechanistically, enhances binding of Sirt3 to MDH2, leading deacetylation decreased activity MDH2. Reduced MDH2 impairs tricarboxylic acid cycle flux,...
The aim of the present study was to investigate clinical efficacy three cannulated screws with parallel distribution in comparison ‘gold standard’ inverting triangular distribution, treatment femoral neck fractures elderly. A total 106 elderly patients treated at Department Orthopedics First Affiliated Hospital Nanjing Medical University (Jiangsu Provincial Hospital) from October 2018 March 2020 were retrospectively analyzed and divided into groups B. Group consisted 51 a mean age 73.3±6.8...
this paper presents a method of scattering center (SC) modelling from geometrical model target. In method, the information targets is firstly extracted meshed targets; and then parametrical SCs built based on local mechanism information. This does not need any numerical computation process; therefore, it can quickly build 3D SC models To validate feasibility Radar Cross Section (RCS) an aircraft target simulated by compared with results full-wave method. The show has high precision in...
Objective To investigate the effects of insulin-like growth factor 1 receptor (IGF1R) on proliferation and extracellular matrix synthesis in rat chondrocytes under cyclic mechanical stress. Methods The were isolated cultured vitro. They randomly divided into four groups: 0 h stress group, 0.5 2 group; each group treated by stretch for h, respectively. Western Blot analysis was performed IGF1R phospho-IGF1R levels chose an array non-pressure cells as control group. The Gel-Pro Analyzer...