A5009929105- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Bacterial Infections and Vaccines
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Actinomycetales infections and treatment
- Helicobacter pylori-related gastroenterology studies
- Veterinary medicine and infectious diseases
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- Antimicrobial Resistance in Staphylococcus
- Ear Surgery and Otitis Media
- Fungal Infections and Studies
- Sepsis Diagnosis and Treatment
- Antimicrobial agents and applications
- Tuberculosis Research and Epidemiology
- Infant Nutrition and Health
- Immune Response and Inflammation
- Enterobacteriaceae and Cronobacter Research
- Immunotherapy and Immune Responses
- Vibrio bacteria research studies
- Metal Extraction and Bioleaching
- Bacterial biofilms and quorum sensing
Inserm
2011-2024
Assistance Publique – Hôpitaux de Paris
2011-2024
Université Paris Cité
2014-2024
Institut Cochin
2014-2024
Centre National de la Recherche Scientifique
2014-2024
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2014-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2024
Hôpital Saint-Louis
2022
University of London Institute in Paris
2022
Hôpital Cochin
2016-2019
To analyse the mechanisms responsible for multidrug resistance in three carbapenem-resistant Klebsiella pneumoniae isolates recovered from two hospitalized patients and an outpatient same hospital Rabat, Morocco.PCR sequencing were used to search β-lactamase genes. Clonal relationships between analysed by multilocus sequence typing PFGE.A history of prior hospitalization ward was determined patients. The K. belonged type (ST), ST15, clonally related. All carried bla(NDM-1) gene co-expressed...
The bacterial pathway for fatty acid biosynthesis, FASII, is a target development of new anti-staphylococcal drugs. This strategy based on previous reports indicating that self-synthesized acids appear to be indispensable Staphylococcus aureus growth and virulence, although other bacteria can use exogenous compensate FASII inhibition. Here we report staphylococci become resistant the FASII-targeted inhibitor triclosan via high frequency mutations in fabD, one genes. fabD mutants conditional...
ABSTRACT Group B Streptococcus (GBS) is the leading cause of neonatal invasive infections and an emerging pathogen in elderly. Our objectives were to describe evolution GBS resistance antibiotics France investigate emergence fluoroquinolone (FQ)-resistant isolates. A total 8,757 unrelated isolates collected tested for antibiotic susceptibility from 2007 2014 according EUCAST recommendations. All susceptible penicillin G, amoxicillin, vancomycin. Resistance macrolides decreased 47.0% 30.0%,...
ABSTRACT Streptococcus agalactiae also named Group B (GBS) is the most significant pathogen causing invasive infections, such as bacteremia and meningitis, in neonates. Worldwide epidemiological studies have shown that a particular clonal complex (CC) of capsular serotype III, CC17, strongly associated with meningitis neonates therefore, designated hypervirulent clone. Macrophages are permissive niche for intracellular bacteria all GBS clones. In this study, we deciphered specific...
Zusammenfassung In diesem Artikel unterscheiden wir mehrere Kernmerkmale alternativer linker Medien und alt-rechter stellen acht Mechanismen des Verrutschens dar, die in drei Formen einteilen: ideologische diskursive Aneignung (postmoderne Subjekte, das intellektuelle Dark Web, Intersektionalität); Umkehrung (sichere Räume Beschwerden) Warenkooptation (Nachahmung der Underground-Ästhetik, Astroturfing koordiniertes unauthentisches Verhalten im Internet). Wir stärken den Stellenwert einer...
Abstract Introduction Antibiotic resistance is a major contributing factor in treatment failure of Helicobacter pylori eradication. Rifabutin ( RB ) rescue and rifampicin RP used to screen vitro. The aim this study was evaluate the rate rifamycins determine mutations rpo B gene conferring discuss current break point. Methods Antimicrobial susceptibility first determined by E ‐test for 1015 H. isolates. MIC s were then agar dilution method strains with > 1 mg/L, sequenced. Results Overall,...
Abstract Background Adapted treatments for Helicobacter pylori infection, guided by determining antimicrobial resistance, are associated with high eradication rates. We evaluated the performance of Amplidiag ® H. + ClariR PCR assay (Amplidiag ) detecting and its clarithromycin resistance from gastric biopsies taken during endoscopy in comparison to culture our “in‐house” PCR. Materials Methods A total 127 were analyzed (98 adults; 29 children). Culture, , in‐house performed parallel. The...
Biofilm production by Haemophilus influenzae and Streptococcus pneumoniae has been implicated in the pathogenesis of otitis media, mainly chronic recurrent cases. We studied "in vitro" biofilm these 2 species isolated alone or together from nasopharynx children with acute media. The strains were 3 pneumococcal conjugate vaccine (PCV) periods: pre-PCV7, post-PCV7/pre-PCV13 post-PCV13. A modified microtiter plate assay crystal violet stain was used to study 182 H. 191 S. strains. Overall,...
We analyzed group B Streptococcus (GBS) neonatal invasive infections reported during 2007-2019 in France. The hypervirulent clonal complex (CC) 17 GBS was responsible for 66% (827/1,262) of cases. role CC17 increased over time (p trend = 0.0001), together with the emergence a multidrug-resistant sublineage.
Group B Streptococcus (GBS) is the leading cause of invasive bacterial neonatal infections. Late-onset diseases (LOD) occur between 7 and 89 days life are largely due to CC17 GBS hypervirulent clone. We studied impact estradiol (E2) progesterone (P4), which impregnate fetus during pregnancy, on infection in cellular mouse models hormonal exposure corresponding concentrations found at birth (E2-P4 C0) over old C7). Using representative isolates, we show that E2-P4 C7 specifically favor...
Candida parapsilosis is the second most frequent species isolated from blood cultures. Since 2005, C. has been divided into three distinct based on genetic traits: parapsilosis, metapsilosis and orthopsilosis. The aim of this study was to develop a rapid real-time PCR assay able distinguish these closely related via melting curve analysis. This identification method optimized by using reference strains well-characterized clinical isolates species. A single set consensus primers designed...
Actinobaculum schaalii is a Gram-positive bacillus increasingly reported as causative agent of urinary tract infections well invasive infections, mainly in the elderly and patients with underlying urological conditions. Since little known about molecular basis antimicrobial resistance A. schaalii, aim this study was to investigate macrolides, lincosamides streptogramins (MLS) emerging pathogen. A total 32 clinical isolates from France Switzerland were studied. MICs erythromycin, spiramycin,...
ABSTRACT Among 1,827 group B Streptococcus (GBS) strains collected between 2006 and 2013 by the French National Reference Center for Streptococci, 490 (26.8%) were erythromycin resistant. The erm (T) resistance gene was found in six belonging to capsular polysaccharides Ia, III, V carried same mobilizable plasmid, which could be efficiently transferred mobilization GBS Enterococcus faecalis recipients, thus promoting a broad dissemination of (T).
Enterococcus faecalis, a multiple antibiotic-resistant Gram-positive bacterium, has emerged as serious nosocomial pathogen. Here, we used genetic approach to characterize the strategies by E. faecalis fulfill its requirements for endogenous fatty acid (FA) synthesis in vitro and vivo. The type II (FASII) pathway is encoded two operons monocistronic genes. Expression of all these genes repressed exogenous FAs, which are incorporated into membrane modify composition. Deletion nine 12-gene...
ABSTRACT Streptococcus agalactiae also named Group B (GBS) is the most significant pathogen causing invasive infections, such as bacteremia and meningitis, in neonates. Worldwide epidemiological studies have shown that a particular clonal complex (CC) of capsular serotype III, CC17, strongly associated with meningitis neonates therefore designated hypervirulent clone. Macrophages are permissive niche for intracellular bacteria all GBS clones. In this study we deciphered specific interaction...