A5077691048- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Amyotrophic Lateral Sclerosis Research
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- EEG and Brain-Computer Interfaces
- S100 Proteins and Annexins
- Neurological diseases and metabolism
- Neurological disorders and treatments
- Gut microbiota and health
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Eosinophilic Esophagitis
- Prion Diseases and Protein Misfolding
- Mycobacterium research and diagnosis
- Bone and Dental Protein Studies
- Bone Metabolism and Diseases
- Nutritional Studies and Diet
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Biotin and Related Studies
- Neurobiology of Language and Bilingualism
Capital Medical University
2022-2024
Chinese Academy of Sciences
1998-2023
Institute of High Energy Physics
2023
University of Chinese Academy of Sciences
2023
McGill University Health Centre
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
Cognitive Neuroimaging Lab
2023
Glymphatic function has not yet been explored in behavioral variant frontotemporal dementia (bvFTD). The spatial correlation between regional glymphatic and bvFTD remains unknown.
Abstract Frontotemporal dementia (FTD) is a disease of high heterogeneity, apathy and disinhibition present in all subtypes FTD imposes significant burden on families/society. Traditional neuroimaging analysis has limitations elucidating the network localization due to individual clinical neuroanatomical variability. The study aims identify atrophy map associated with different determine specific for disinhibition. Eighty patients [45 behavioural variant (bvFTD) 35 semantic progressive...
Neuroinflammation plays a significant role in the progression of frontotemporal dementia (FTD). However, association between peripheral inflammatory factors and brain neurodegeneration is poorly understood. We aimed to examine changes markers patients with behavioural variant FTD (bvFTD) explore potential inflammation structure, metabolism, clinical parameters.Thirty-nine bvFTD 40 healthy controls were enrolled underwent assessment plasma factors, positron emission tomography/magnetic...
There is a substantial body of observational research indicating an association between hearing impairment and dementia, yet the causal relationship underlying mechanisms remain uncertain. This study aims to investigate its subtypes with dementia cognitive function using two-sample Mendelian randomization (MR) analysis.
Abstract Background Behavioral variant frontotemporal dementia (bvFTD) is predominantly considered a dysfunction in cortico-cortical transmission, with limited direct investigation of cortical-subcortical transmission. Thus, we aimed to characterize the metabolic connectivity between areas limbic cortico-striato-thalamic-cortical (CSTC) circuit presymptomatic and symptomatic bvFTD patients. Methods Thirty-three patients 33 unrelated healthy controls were recruited for this study....
<h3>Background:</h3> There is growing evidence that the striatum plays a central role in cognitive dysfunction. However, it remains unclear whether and how contributes specifically to executive deficits Alzheimer disease (AD). We sought elucidate aberrations striatal subregion associated with function its metabolic connectivity cortical regions investigate pathogenesis of patients AD. <h3>Methods:</h3> Patients AD healthy controls underwent neuropsychological assessment battery, including...
Increasing evidence suggests an association between
Graph theory is a novel approach used to examine the balance of brain connectomes. However, clinical relevance white matter (WM) connectome changes in behavioral variant frontotemporal dementia (bvFTD) not well understood. We aimed investigate WM topological alterations bvFTD. Thirty patients with probable bvFTD and 30 healthy controls underwent diffusion tensor imaging, structural MRI, neuropsychological assessment. connectivity between 90 regions was calculated graph applied capture...
Abstract Background Vascular dysfunction was recently reported to be involved in the pathophysiological process of neurodegenerative diseases, but its role sporadic behavioral variant frontotemporal dementia (bvFTD) remains unclear. The aim this study systematically explore vascular dysfunction, including changes white matter hyperintensities (WMHs) and peripheral markers bvFTD. Methods Thirty-two patients with bvFTD who no risk factors were enrolled cross-sectional assessed using positron...
Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal rapidly progressive neurodegenerative disorder with no effective therapeutic interventions. We aimed to identify potential genetically-supported drug targets for sCJD by integrating multi-omics data. Multi-omics-wide association studies, Mendelian randomization, and colocalization analyses were employed explore using expression, single-cell DNA methylation, protein quantitative trait locus data from blood brain tissues. Outcome was...
Background Previous studies have shown that gut microbiota dysbiosis could affect clinical prognosis through an unknown mechanism. However, the causal relationship between and functional outcome after ischemic stroke remains unclear. We aimed to investigate association using Mendelian randomization (MR). Methods Genetic instrumental variables associated with 211 bacterial traits were obtained from MiBioGen consortium ( N = 18,340). Data genome-wide (GWAS) for two phenotypes (i.e., overall...
Abstract Background The pattern of glymphatic inflow overlaps with the geographic behavioral variant frontotemporal dementia (bvFTD). function has not yet been explored in bvFTD. spatial correlation between regional and bvFTD remain unknown. Method A total 60 patients 61 age‐ sex‐matched healthy controls (HCs) were selected from two independent cohorts (discovery dataset Xuanwu Hospital replication Frontotemporal Lobar Degeneration Neuroimaging Initiative study). All participant underwent...
Background: Research on posterior cortical atrophy (PCA) has focused cognitive decline, especially visual processing deficits. However, few studies have examined the impact of PCA activities daily living (ADL) and neurofunctional neuroanatomic bases ADL. Objective: To identify brain regions associated with ADL in patients. Methods: A total 29 patients, 35 typical Alzheimer’s disease (tAD) 26 healthy volunteers were recruited. Each subject completed an questionnaire that included basic...
Background: The insula is the predominant brain region impaired in behavioral variant frontotemporal dementia (bvFTD). However, structural and functional changes sub-insula asymptomatic stage of bvFTD are unknown. Objective: To describe subregions carriers P301L mutation microtubule-associated protein tau ( MAPT) gene patients with bvFTD. Methods: Six MAPT 12 negative control subjects same pedigree were enrolled, along 30 a clinical diagnosis matched controls. All underwent hybrid positron...
Background: Although the pulvinar is known for its visual function and extensive connections with cortical areas, volumetric change functional connectivity of in posterior atrophy (PCA) remain unclear.Objective: To identify changes PCA patients relevant associations higher dysfunction.Methods: A total 29 30 normal controls were recruited. Each participant underwent a comprehensive neuropsychological assessment both structural resting-state MRI scanning. Voxel-based morphometry (VBM)...
Abstract Background The vascular disturbance was recently found in a postmortem study of frontotemporal dementia (FTD), but whether dysfunction exists the early stage FTD remains elusive. aimed to explore there evidence and its relationship with central neurodegeneration clinical outcome. Method Twenty patients behavior (bvFTD) were enrolled underwent assessment peripheral plasma markers, positron emission tomography/magnetic resonance imaging, neuropsychological examinations. Group...
Abstract Background Progranulin (GRN) mutations of Frontotemporal dementia (FTD) were rarely reported in China. This study was to report one novel GRN mutation and summarize the genetic clinical features patients with Method Comprehensive clinical, genetic, neuroimaging examinations conducted on a 58‐year‐old patient who diagnosed semantic variant primary progressive aphasia. A literature review also China summarized. Result Marked lateral atrophy hypometabolism left‐side frontal, temporal...
Abstract Background The insula is the predominant brain region impaired in behavior variant frontotemporal dementia (bvFTD). However, structural and functional changes sub‐insula asymptomatic stage of bvFTD are unknown. aim this study to describe insular subregions carriers P301L mutation microtubule‐associated protein tau ( MAPT ) gene patients with bvFTD. Method Six 12 negative control subjects same pedigree were enrolled, along 30 a clinical diagnosis matched controls. All underwent...