A5001321993- Periodontal Regeneration and Treatments
- Colorectal Cancer Treatments and Studies
- Mesenchymal stem cell research
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Neutropenia and Cancer Infections
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Oral Health Pathology and Treatment
- Salivary Gland Disorders and Functions
- Bone and Joint Diseases
- Parkinson's Disease and Spinal Disorders
- Oral and gingival health research
- dental development and anomalies
- Inflammatory Biomarkers in Disease Prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced biosensing and bioanalysis techniques
- Tissue Engineering and Regenerative Medicine
- Genetic factors in colorectal cancer
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
Medical University of Sofia
2016-2024
Military Medical Academy
2014-2022
University of Dental Medicine
2019
Sofia University "St. Kliment Ohridski"
2019
Alexandrovska Hospital
2019
Military Medical Academy
2014-2015
Polymeric nanoparticles have been introduced as a delivery vehicle for active compounds in broad range of medical applications due to their biocompatibility, stability, controlled release compounds, and reduced toxicity. The oral route is the most used approach biologics body. homeostasis function cavity tissues are dependent on activity stem cells. present work focuses, first time, interaction between two types polymeric nanoparticles, poly (lactic-co-glycolic acid) or PLGA PLGA/chitosan,...
Oral cancer is an aggressive disease characterized by low average survival rates. Purpose: To examine the periodontal status in cases of primary oral squamous cell carcinoma (OSCC), potentially malignant disorders (OPMD), periodontitis, and healthy individuals relation to its impact on development OSCC OPMD. Materials/Methods: The study involved 107 with age 54.22±14.38 years (58.9% male, 41.1% female), divided into four groups: Group I – patients (n=43); II OPMD (n=21); III periodontitis IV...
In the light of recent retrovirus pandemics, issue discovering new and diverse RNA-specific fluorochromes for research diagnostics became acute importance. The great majority nucleic acid-specific probes either do not stain RNA or cannot distinguish between DNA RNA. versatility polymethine dyes makes them suitable as stains visualization, analysis, detection acids, proteins, other biomolecules. We synthesized asymmetric dicationic homodimeric monomethine cyanine...
Abstract The endodontic treatment of immature permanent teeth with necrotic pulp is a serious clinical challenge. chemical agents, used in regenerative procedures, should be selected not only based on their bactericidal/bacteriostatic properties, but also ability to ensure the survival patient’s stem cells. aim this study was evaluate effect citric acid vitality SCAP model an tooth root. Models roots were created from 12 freshly extracted teeth. models gas sterilized ethylene oxide and they...
Biopsy and histopathological examination continue to be the gold standards for diagnosing oral cancer potentially malignant disorders (OPMD). The prognosis of these conditions is significantly influenced by established factors such as degree dysplasia, tumour size, grade, patient age. While traditional diagnostic approaches are crucial, there a growing need innovative methods improve diagnosis monitoring conditions. We hypothesize that identifying specific biomarkers in human saliva,...
The development of fluorescence-based methods for bioassays and medical diagnostics requires the design synthesis specific markers to target biological microobjects. However, biomolecular recognition in real cellular systems is not always as selective desired. A new concept creating fluorescent probes, utilizing a fluorogenic dye biodegradable, biocompatible nanomaterials, demonstrated. dicationic asymmetric monomethine cyanine with benzo[d]thiazolium-N-propionamide chloroquinoline end...
Abstract Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but serious pathology associated with use bisphosphonates (BPs) and antiresorptive drugs in patients bone metastases, multiple myeloma osteoporosis. Various cases necrosis due to BPs have recently been reported literature. Anti-angiogenic are novel anticancer agents prescribed renal carcinoma, lung soft tissue etc. target vascular endothelial growth factor’s (VEGF) signaling pathways via different mechanisms...
Stem cells are undifferentiated cell type characterized by colonogenic ability, self-renewal and multi-lineage differentiation. They classified into the following categories: embryonic stem [ESC], somatic [or adult cells] induced pluripotent [iPSC]. represent area of interest for wide range scientists, as they promising tool regenerative therapy. Their differentiation ability is significantly affected various factors local environment. Additional research will provide more information about...
We report a case of osteonecrosis the jaw (ONJ) associated with denosumab therapy in 69-year-old female patient being treated for osteoporosis.The was admitted Oral and maxillofacial surgery clinic twice because nonhealing extraction wounds inflammatory complications.We recommend conservative therapeutic approach avoidance extensive patients ONJ.
Lipoma of the parotid gland is a rare benign mesenchymal tumor.It seldom considered in differential diagnosis salivary glands pathology.Lipoma represents approximately 1% tumors.We report clinical case 54-year-old male patient presented with 5-year history painless, slowgrowing mass left gland.The management choice was surgical removal lateral lobe facial nerve preservation.No tumor recurrence, palsy or pain noted postoperatively..
Aneurysmal bone cyst (ABC) is a rare benign, non-odontogenic osteolytic lesion of the jawbones.Commonly clinical presentation consists pain, significant expansion and facial asymmetry.We report case 14-year-old asymptomatic patient, with aneurysmal cyst, identified on routine X-ray, mistaken dentigerous cyst.Thorough surgical removal cystic was carried out, followed by histopathological examination confirming diagnosis.Long term follow-up showed no complications or recurrence.
Abstract Growth factors (GFs) are bioactive molecules participating in organ development, tissue regeneration and repair. They protein with a relatively low molecular weight released by activated platelets. Platelet-derived growth factor (PDGF) is one of the GFs highest amount human It known to stimulate cell proliferation extracellular matrix synthesis, as well angiogenesis healthy tissues neoplasms. However, most studies literature demonstrate influence PDGF on without revealing its...
Cell senescence is a continuous irreversible process, ending with cell death. Long-term in vitro cultivation leads to decreased proliferation ability, disruption cellular morphology and function somatic cells. The aim of the present study was investigate markers cycle arrest after long-term periodontal ligament stem cells (PDLSC). were isolated from routinely extracted third molars via enzymatic digestion cultured continuously up passage 16. count population doubling evaluated at each...