A5101800407- Natural product bioactivities and synthesis
- Ubiquitin and proteasome pathways
- Bioactive Compounds in Plants
- Autophagy in Disease and Therapy
- Museums and Cultural Heritage
- Cholinesterase and Neurodegenerative Diseases
- Cancer therapeutics and mechanisms
- Reproductive biology and impacts on aquatic species
- Kruppel-like factors research
- Andrographolide Research and Applications
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Medicinal Plants and Bioactive Compounds
- Aquaculture Nutrition and Growth
- Marine Sponges and Natural Products
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Treatments and Mutations
- Neurological Disorders and Treatments
- Nicotinic Acetylcholine Receptors Study
- Protein Degradation and Inhibitors
- Cell death mechanisms and regulation
- Atherosclerosis and Cardiovascular Diseases
- Sesquiterpenes and Asteraceae Studies
- Aquaculture disease management and microbiota
- Microbial Metabolism and Applications
National Cheng Kung University
2020-2024
National Yang Ming Chiao Tung University
2016-2022
University of Science and Technology of China
2018
Tzu Hui Institute of Technology
2017
National Chung Hsing University
2014
China Medical University
2012-2013
Kang-Ning Junior College of Medical Care and Management
2009-2013
National Taiwan University
2013
Drug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue important and urgent. In study, we found that targeting USP24 by specific inhibitors, USP24-i its analogues, dramatically activated autophagy interphase mitotic periods of lung cells inhibiting E2F4 TRAF6, respectively. functional knockout,
Previous studies indicate that estrogen positively regulates lung cancer progression. Understanding the reasons will be beneficial for treating women with in future. In this study, we found tumor formation was more significant female EGFRL858R mice than male mice. P53 expression levels were downregulated estradiol (E2)-treated cells, EGFRL858R-induced mice, and premenopausal cancer. E2 increased DNA methyltransferase 1 (DNMT1) to enhance methylation TP53 promoter, which led downregulation of...
Abstract Background The present study was undertaken to evaluate the anti-depressive activity of turmerone after one-week administration by using a mouse forced swimming test (FST) and tail suspension (TST). Methods Animals were divided into four groups (n = 10 /group): control (0.9% saline), three doses (1.25, 2.5, 5.0 mg/kg) for treatment. To assess effect on locomotor activity, mice evaluated in open-field paradigm. Forced Tail (TST) used take as measure antidepressant activity. probable...
Sp1, an important transcription factor, is involved in the progression of various cancers. Our previous studies have indicated that Sp1 levels are increased early stage lung cancer but decrease during late stage, leading to poor prognosis. In addition, estrogen has been shown be progression. According studies, can interact with receptor (ER) coregulate gene expression. The role interaction between and ER still unknown will clarified this study.The clinical relevance survival rates young...
Pogostemon cablin (PC) is a herbal medicine traditionally applied to treat not only common cold, nausea and diarrhea but also headache fever. The aim of this study was investigate the analgesic anti-inflammatory properties standardized PC methanol extract (PCMeOH) in vivo. Investigations were performed mice with two models. One acetic acid-induced writhing response other formalin-induced paw licking. effect tested by λ-carrageenan (Carr)-induced edema. These experimental results indicated...
// De-Wei Lai 1 , Shing-Hwa Liu 2,* Anna Isabella Karlsson 3 Wen-Jane Lee 4,* Keh-Bin Wang 5 Yi-Ching Chen Chin-Chang Shen 6 Sheng-Mao Wu Chia-Yu Hsing-Ru Tien Yen-Chun Peng 7 Yee-Jee Jan 8 Te-Hsin Chao 9 Keng-Hsin Lan 10,11 Jack L. Arbiser and Meei-Ling Sheu 1,4,12 Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan 2 Toxicology, College Medicine, Taipei, Department Dermatology, Emory University School Winship Cancer Institute, Atlanta Veterans Administration...
Abstract Drug resistance has remained an important issue in the treatment and prevention of various diseases, including cancer. Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreasing Rad51 expression to cause tumor genomic instability cancer stemness, but also increased levels ATP-binding cassette (ABC) transporters P-gp, ABCG2, ezrin enhance pumping out Taxol from cells, thus resulted drug during therapy. A novel inhibitor, NCI677397, was screened for...
Inflammation is related to several chronic diseases, including cancer and atherosclerosis. Taxillus sutchuenensis (Lecomte) Danser a special folk medicinal plant in Taiwan. The aim of this study was evaluate the antioxidant, anti-inflammatory, antiproliferative activities aqueouse-thanol extract from T. (AETS) its fractions. TEAC, DPPH radicals, total phenolic compounds, flavonoid content, inhibition NO production LPS-induced RAW264.7 cells, cell proliferation were tested. Among all...
Abstract Bromodomain (BRD)-containing proteins are important for chromatin remodeling to regulate gene expression. In this study, we found that the deubiquitinase USP24 interacted with BRD through its C-terminus increased levels of most BRD-containing increasing their protein stability by removal ubiquitin from Lys391/Lys400 BRD. addition, and BRG1 could each other regulating transcriptional activity, respectively, other, suggesting regulated form a positive feedback loop in cancer...
The diameter of PM2.5 is less than that 2.5 μg/m3 particulate matter; small enough to enter the body through alveolar microvasculature and has a major impact on human health. Therefore, people are interested in establishment air quality monitoring forecasting. historical current indices (AQI) can now be easily obtained from sensors. However, more likely need forecasting information. Based literature, varies because variety factors, such as meteorology urban areas. In this paper,...
Aquatic animals have great economic and ecological importance. Among them, non-model organisms been studied regarding eco-toxicity, stress biology, environmental adaptation. Due to recent advances in next-generation sequencing techniques, large amounts of RNA-seq data for aquatic are publicly available. However, currently there is no comprehensive resource exist the analysis, unification, integration these datasets. This study utilizes computational approaches build a new transcriptomic maps...
Anguilla japonica (Japanese eel) is currently one of the most important research subjects in eastern Asia aquaculture. Enigmatic life cycle organism makes study artificial reproduction extremely limited. Henceforth genomic and transcriptomic resources eels are urgently needed to help solving problems surrounding this across multiple fields. We hereby provide a reconstructed transcriptome from deep sequencing juvenile (glass eels) whole body samples. The provided expressed sequence tags were...
In this study, the analgesic activities and mechanism of anti-inflammatory 50% ethanol extract from TS (ETS) in vivo were investigated. Investigations were performed in mice with 2 models: acetic acid-induced writhing response formalin-induced paw licking. The effect was tested by λ-carrageenan (Carr)-induced edema. These results indicated that ETS at a dose 0.5 1.0 g/kg reduced responses licking time late phase formalin test. Moreover, Carr-induced edema significantly when...
Tumor heterogeneity is the major factor for inducing drug resistance. p53 defender to maintain genomic stability, which a high proportion mutated in most of cancer types. In this study, we established vivo animal models gefitinib-induced drug-resistant lung containing EGFRL858R and EGFRL858R*Tp53+/- mice explore molecular mechanisms resistance by studying integrity global gene expression. The cellular morphology tumors between drug-sensitive were very different. addition, mice, expression...