A5103006163- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Neuropeptides and Animal Physiology
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Ion channel regulation and function
- Respiratory Support and Mechanisms
- Receptor Mechanisms and Signaling
- Chemokine receptors and signaling
- Chronic Disease Management Strategies
- Birth, Development, and Health
- Cardiac Health and Mental Health
- Pediatric health and respiratory diseases
- Health and Lifestyle Studies
- Obesity, Physical Activity, Diet
- COVID-19 and Mental Health
- Cytomegalovirus and herpesvirus research
- Pharmacology and Obesity Treatment
- S100 Proteins and Annexins
- Cardiovascular Effects of Exercise
- Colorectal Cancer Screening and Detection
- Cancer survivorship and care
- Diabetes Treatment and Management
- Stroke Rehabilitation and Recovery
- Health, psychology, and well-being
University of Leicester
2010-2022
NIHR Leicester Biomedical Research Centre
2018-2022
Institute of Genomics and Integrative Biology
2019-2021
University of Limpopo
2020
University Hospitals of Leicester NHS Trust
2009-2020
Glenfield Hospital
2010-2019
Loughborough University
2017-2019
Leicester Royal Infirmary
2012-2016
University of Nottingham
2007-2014
Queen's Medical Centre
2014
Asthma is characterized by variable airflow obstruction, airway inflammation, hyper-responsiveness and remodelling. Airway smooth muscle (ASM) hyperplasia a feature of remodelling contributes to bronchial wall thickening. We sought investigate the expression levels chemokines in primary cultures ASM cells from asthmatics vs healthy controls assess whether differentially expressed (i) promote fibrocyte (FC) migration towards (ii) are increased blood subjects with asthma sputum samples those
Abstract- This research aimed to investigate the anxiety and stress levels among post caesarean mothers in experimental control group. Many face some discomfort after section like pain, mood changes, postpartum depression stress. Anxiety were evaluated by using quantitative approach with quasi pre-test post-test group design non probability purposive sampling technique, total 30 subjects {Experimental (15) Control (15)} recruited. The intervention was given twice a day for four consecutive...
BackgroundFibrocytes are bone marrow–derived CD34+ collagen I–positive cells present in peripheral blood that develop α-smooth muscle actin expression and contractile activity tissue culture. They implicated the pathogenesis of remodeling fibrosis both patients with asthma those idiopathic pulmonary fibrosis. Targeting fibrocyte migration might therefore offer a new approach for treatment these diseases. Ion channels play key roles cell function, but ion-channel repertoire human fibrocytes...
There is evidence supporting a role for the nociceptin/orphanin FQ (N/OFQ; NOP) receptor and its endogenous ligand N/OFQ in modulation of neurogenic inflammation, airway tone calibre. We hypothesized that NOP activation has beneficial effects upon asthma immunopathology hyperresponsiveness. Therefore, expression function were examined healthy asthmatic human tissues. The concept was further addressed an animal model allergic asthma.NOP investigated by quantitative real-time PCR. Sputum...
The airway epithelium plays an important role in wound repair, host defense and is involved the immunopathogenesis of asthma. Genome wide association studies have described associations between ST2/Interleukin (IL)-33 genes asthma, but its bronchial unclear.ST2 expression was examined subjects with asthma healthy controls from biopsies (n = 27 versus n 9) brushings 34 20) by immunohistochemistry RNA-Seq. In human primary epithelial cells ST2 mRNA protein were assessed qPCR, flow cytometry,...
<h3>Objectives</h3> Structured physical training programmes are a key component of pulmonary rehabilitation (PR) and have consistently been shown to be significant benefit patients with COPD. It is unclear whether the application similar principles provides health improvements in severe asthma. We aimed assess this by studying effects group asthma disability who completed our standard 7 week PR programme. <h3>Methods</h3> 111 physician diagnosis programme were studied. Assessments including...
<h3>Introduction</h3> The NHS Outcomes Strategy for COPD has identified self-management as an approach targeted at reducing the impact of COPD.<sup>1</sup> Previous programmes have either been unsupported, such brief education or action plans, high intensity, equivalent with pulmonary rehabilitation. Furthermore, no studies specifically tested in patients managed primary care. SPACE is a supported programme that adopts light touch approach. This study aimed to test effectiveness...
Mesenchyme-derived airway cell populations including smooth muscle (ASM) cells, fibroblasts and myofibroblasts play key roles in the pathogenesis of inflammation remodeling. Phenotypic functional characterisation these are confounded by their heterogeneity vitro. It is unclear which mechanisms underlie creation different sub-populations. The study objectives were to investigate whether ASM cells capable clonal expansion if so (i) what proportion possess this capability (ii) do exhibit...
<ns4:p><ns4:bold>Background</ns4:bold>: Body mass index (BMI) is the most popular anthropometric marker to define obesity and cardiometabolic risk. BMI limited in its ability discriminate central adiposity other indices such as waist circumference (WC), height ratio (WHtR) could be a better choice. In this study, we aimed evaluate relative accuracy of these for prediction hypertension Indian children young adults.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: Anthropometric blood pressure...
This shows that it is feasible to deliver a self-management package in primary care as stand alone manual, with significant improvements demonstrated dyspnoea, exercise performance and anxiety.
<h3>Introduction and objectives</h3> Chronic Obstructive Pulmonary Disease (COPD) is a small airway disease associated with ventilation heterogeneity. The Lung Clearance Index (LCI) potential early marker of lung damage has been demonstrated to be repeatable within visit for patients stable COPD. We sought evaluate the feasibility repeatability LCI between visits among subjects <h3>Methods</h3> was measured by performing an inert Multiple Breath Washout using modified photoacoustic Innocor...
<h3>Introduction</h3> Readmission to hospital following an acute exacerbation of COPD is a significant burden patients and health providers. Care bundles are increasingly used support discharges admitted with COPD. Referral smoking cessation, nicotine replacement therapy pulmonary rehabilitation services key elements care but it not known if uptake these interventions predicts readmission. <h3>Methods</h3> This was retrospective audit who received discharge bundle from April 2012 March 2014....
<h3>Background</h3> Current BTS/SIGN guidelines suggest the inclusion of behavioural interventions as part management for overweight patients with Obstructive Sleep Apnoea Syndrome (OSAS). Healthy lifestyle are widely available in a variety settings other chronic diseases. Our aims were to assess: patients’ views and their experience weight loss changes. Internet Information Technology (IT) access investigate if web-based intervention would be feasible. current clinical practice regarding...
<h3>Background</h3> Reduced activity is a routine observation following major surgery, however no studies have yet measured or explored this. Causative factors include sedative drugs, reduced exercise tolerance and pain, as well pre-existing pathology. We aimed to measure postoperative observe outcomes of thoracotomy lung resection patients, identify predictive factors. <h3>Methods</h3> A prospective observational study was conducted in regional thoracic surgery centre. Sense Wear Pro 3...
<h3>Background</h3> Patients with difficult-to-treat asthma often have dyspnoea which limits their physical activity. This may lead to progressive deconditioning further hamper exercise capacity. We aimed assess current levels of activity, perceptions fitness and interest in a structured programme patients attending the Glenfield Hospital Difficult Asthma Clinic. <h3>Method</h3> completed General Practice Physical Activity Questionnaire provides simple Index (PAI) answered questions about...
<h3>Introduction</h3> Exercise tests are a keystone in assessing patients for Pulmonary Rehabilitation (PR). Behavioural research has suggested that performing an outcome measure may influence the outcome.<sup>1</sup> This not been explored respiratory disease relation to exercise test. Performing could improve confidence and alter subsequent behaviour. <h3>Aim</h3> To assess if completing single incremental shuttle walk test (ISWT) increases patients' walking at home; managing...
<b>Background:</b> In global surveys, Indians had the worst spirometric volumes, which is of concern since low lung function has been associated with premature mortality and cardiometabolic disease risk <b>Aims Objectives:</b> We aimed to explore whether there any underlying pathophysiology in Indians, or if it a normal ethnic variation. This would determine variations should be adjusted for by local equations, as currently practiced, used towards precision health. <b>Methodology:</b>...