A5010149969- Mast cells and histamine
- Hormonal Regulation and Hypertension
- Nitric Oxide and Endothelin Effects
- Synthesis and Biological Evaluation
- Acute Myocardial Infarction Research
- Peroxisome Proliferator-Activated Receptors
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Pain Management and Opioid Use
- Cardiac electrophysiology and arrhythmias
- Chemical Synthesis and Analysis
- Renin-Angiotensin System Studies
- Ion channel regulation and function
- Click Chemistry and Applications
- Cardiac Ischemia and Reperfusion
- Cardiovascular Issues in Pregnancy
- Pharmacological Effects and Toxicity Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Attention Deficit Hyperactivity Disorder
- Synthesis and Catalytic Reactions
- Cardiac Fibrosis and Remodeling
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Palliative Care and End-of-Life Issues
- Cancer, Lipids, and Metabolism
Shionogi (Japan)
2000-2024
Yokohama City University
2024
Tsukuba Medical Center Hospital
2024
University of Tsukuba Hospital
2024
International University of Health and Welfare
2024
Futaba (Japan)
1998-2023
University of Tsukuba
2023
Takeda (Japan)
2021
Kantar Health (United States)
2021
University of Fukui
2021
Abstract Objectives Opioid availability for the palliative care of patients with advanced cancer is increasing globally. However, opioid remains extremely low in Japan. We investigated whether pain appropriately controlled by low-dose prescriptions Methods A web-based nationwide survey caregivers from 2000 community comprehensive support centers was performed Japan to assess details about 30 days before died end-stage cancer. Separately, data prescription doses and medical services 90 death...
Introduction Naldemedine and magnesium oxide are common first-line early laxative medications used in the real-world scenario Japan, for patients with cancer pain who receive opioid prescriptions, as per a nationwide hospital claims database study. However, prescription patterns associated outcomes unknown. Methods In this retrospective, cohort study using Medical Data Vision (MDV) (January 2018 to December 2020), data were collected from eligible (who had long-term of strong opioids, >30...
Targeting aldosterone synthesis and/or release represents a potentially useful approach to the prevention of cardiovascular disease. Aldosterone production is stimulated by angiotensin II (Ang II) or extracellular K+ and mediated mainly Ca2+ influx into adrenal glomerulosa cells through T-type calcium channels. We therefore examined effects efonidipine, dual T-type/L-type channel blocker, on secretion in H295R human adrenocarcinoma cell line; 100 nmol/L Ang 10 mmol/L respectively increased...
Abstract Objectives Opioid availability for the palliative care of patients with advanced cancer is increasing globally. However, opioid remains extremely low in Japan. We investigated whether pain appropriately controlled by low‐dose prescriptions Methods A web‐based nationwide survey caregivers from 2000 community comprehensive support centers was performed Japan to assess details about 30 days before died end‐stage cancer. Separately, data prescription doses and medical services 90 death...
Percutaneous coronary intervention (PCI) is currently the most widely accepted treatment for acute myocardial infarction (AMI). It remains unclear, however, whether post-AMI conditions might exacerbate neointimal hyperplasia and restenosis following PCI. Given that both a medial smooth muscle cell lineage bone marrow (BM)-derived hematopoietic stem are now thought to contribute neointima formation, primary aims of present study were determine AMI augments at sites arterial injury, BM-derived...
Peroxisome proliferator-activated receptor δ (PPARδ) is considered to be a pharmaceutical target treat metabolic diseases including atherosclerosis, but there no PPARδ agonist available for clinical use. We have previously reported the discovery of piperidinyl/piperazinyl benzothiazole derivatives as new series agonists using docking-based virtual screening methods. In present study, we found that introduction pyrrolidine group into 4-position their central piperidine rings enhances hPPARδ...
Background: Opioid-induced constipation is common and greatly affects the quality of life but often under-recognised undertreated. This study aimed to investigate safety effectiveness naldemedine for opioid-induced with cancer pain according specific subgroups clinical interest. Methods: In this exploratory post-hoc subgroup analysis post-marketing surveillance from Japan (UMIN: 000042851), data were investigated by subgroups: age (≥75, <75 years), Eastern Cooperative Oncology Group...
The effects of endothelin (ET)-1(1-31) and ET-2(1-31), human chymase products the corresponding big ETs, on intracellular free Ca2+ concentration ([Ca2+]i) [125I]-ET-1 binding were investigated using cultured bronchial smooth muscle cells (BSMC). ET-1(1-31) (10(-8)M - 3 x 10(-7)M) ET-2(1-31) (3 10(-8)M 10(-6) M) caused an increase in [Ca2+]i a concentration-dependent manner. Big ET-1 10(-6)M) also this increase, but not ET-2 at concentrations up to 10(-6)M. induced by was inhibited both...
Aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) regulate aldosterone cortisol production, respectively. The expression of these enzymes is promoted by calcium influx through Cav3.2, a T-type channel. Neuron-restrictive silencer factor (NRSF) binds to neuron-restrictive element (NRSE) suppress the transcription NRSE-containing genes. We found NRSE-like sequence in human CYP11B2 CYP11B1 genes as well CACNA1H gene many mammalian species. encodes α-subunit Cav3.2. Here we...
Hyperinsulinemia is widely thought to be a compensatory response insulin resistance, whereas its potentially causal role in the progression of resistance remains established. Here, we aimed examine whether hyperinsulinemia could affect Zucker fatty diabetic (ZDF) rats. Male ZDF rats at 8 wk age were fed diet ad libitum (AL) or dietary restriction (DR) either 15 30% from AL feeding over 6 wk. Insulin sensitivity was determined by hyperinsulinemic euglycemic clamp. group progressively...
Background Symptoms experienced by adult patients with attention-deficit/hyperactivity disorder (ADHD) frequently result in functional impairment across academic/occupational functioning, daily life, and social functioning. A substantial proportion of undiagnosed untreated ADHD has been suggested Japan. This study aims to better understand the potential population Japan quantifying burden associated symptoms through a comparison prevalence comorbidities, health-related quality life (HRQoL),...
Although sonothrombolysis has been studied for development of recanalization that is safer and more efficacious than the methods currently used, there have no studies efficacy platelet-rich thrombi typically cause acute myocardial infarction (AMI). The effects adding ultrasound (US) to pharmacological lysis was examined in a rabbit model femoral artery occlusion.In 35 rabbits, right balloon-injured repeatedly at 4-week intervals induce thrombi. Two hours after induction occlusive thrombi,...
Vascular response mediating endothelin (ET)B receptor was studied using isolated rabbit mesenteric arteries. ET-1 (0.1-30 nM) caused a concentration-dependent contraction, whereas ET-3 >100 nM only weak contraction. Up to 1 microM of sarafotoxin S6c showed no In arteries precontracted with phenylephrine, (0. 03-1 relaxation, which not affected by endothelium denudation. The ET-3-induced relaxation antagonized BQ-788 and PD-142893 but BQ-123 in the endothelium-denuded Treatment indomethacin...